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Gene: ACP7 |
Gene summary for ACP7 |
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Gene information | Species | Human | Gene symbol | ACP7 | Gene ID | 390928 |
Gene name | acid phosphatase 7, tartrate resistant (putative) | |
Gene Alias | PAPL | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006793 | UniProtAcc | Q6ZNF0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
390928 | ACP7 | HCC1 | Human | Liver | HCC | 4.33e-02 | 2.92e-01 | 0.5336 |
390928 | ACP7 | HCC2 | Human | Liver | HCC | 1.55e-09 | 1.09e+00 | 0.5341 |
390928 | ACP7 | HCC5 | Human | Liver | HCC | 2.17e-08 | 7.21e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACP7 | SNV | Missense_Mutation | c.892G>A | p.Asp298Asn | p.D298N | Q6ZNF0 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD | |
ACP7 | deletion | Frame_Shift_Del | novel | c.127delN | p.Pro43GlnfsTer4 | p.P43Qfs*4 | Q6ZNF0 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ACP7 | SNV | Missense_Mutation | novel | c.51C>G | p.Phe17Leu | p.F17L | Q6ZNF0 | protein_coding | tolerated(0.23) | benign(0) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ACP7 | SNV | Missense_Mutation | c.13N>T | p.Pro5Ser | p.P5S | Q6ZNF0 | protein_coding | tolerated_low_confidence(0.47) | benign(0) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ACP7 | SNV | Missense_Mutation | c.218G>A | p.Arg73His | p.R73H | Q6ZNF0 | protein_coding | tolerated(0.1) | benign(0.191) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
ACP7 | SNV | Missense_Mutation | rs766788180 | c.1171N>T | p.Arg391Cys | p.R391C | Q6ZNF0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
ACP7 | SNV | Missense_Mutation | rs747641850 | c.860G>A | p.Arg287Gln | p.R287Q | Q6ZNF0 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ACP7 | SNV | Missense_Mutation | c.404G>A | p.Arg135His | p.R135H | Q6ZNF0 | protein_coding | tolerated(0.12) | benign(0.04) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ACP7 | SNV | Missense_Mutation | c.217N>T | p.Arg73Cys | p.R73C | Q6ZNF0 | protein_coding | deleterious(0.03) | benign(0.394) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
ACP7 | SNV | Missense_Mutation | c.652N>T | p.Arg218Cys | p.R218C | Q6ZNF0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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