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Gene: ACOXL |
Gene summary for ACOXL |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ACOXL | Gene ID | 55289 |
| Gene name | acyl-CoA oxidase like | |
| Gene Alias | ACOXL | |
| Cytomap | 2q13 | |
| Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | B4DU63 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 55289 | ACOXL | RNA-P23T2-P23T2-1 | Human | Lung | MIAC | 2.43e-03 | 1.05e+00 | -0.037 |
| 55289 | ACOXL | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 3.98e-25 | 1.06e+00 | -0.2116 |
| 55289 | ACOXL | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 9.95e-14 | 1.12e+00 | -0.1941 |
| 55289 | ACOXL | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 2.35e-09 | 9.18e-01 | -0.2107 |
| 55289 | ACOXL | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 5.89e-30 | 1.19e+00 | -0.2119 |
| 55289 | ACOXL | RNA-P5T2-P5T2-1 | Human | Lung | MIAC | 8.13e-05 | 1.42e+00 | -0.0135 |
| 55289 | ACOXL | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 6.53e-09 | 1.41e+00 | -0.0238 |
| 55289 | ACOXL | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 4.81e-10 | 1.47e+00 | -0.0186 |
| 55289 | ACOXL | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 1.54e-10 | 1.52e+00 | -0.0296 |
| 55289 | ACOXL | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 2.49e-11 | 1.37e+00 | -0.0263 |
| 55289 | ACOXL | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.28e-22 | 7.33e-01 | -0.0166 |
| 55289 | ACOXL | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 4.86e-28 | 8.03e-01 | -0.0132 |
| 55289 | ACOXL | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.84e-30 | 8.54e-01 | -0.013 |
| 55289 | ACOXL | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 3.37e-23 | 7.68e-01 | -0.0121 |
| 55289 | ACOXL | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 1.51e-09 | 9.29e-01 | -0.0961 |
| 55289 | ACOXL | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 8.19e-11 | 9.60e-01 | -0.0876 |
| 55289 | ACOXL | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 1.79e-05 | 7.31e-01 | -0.0822 |
| 55289 | ACOXL | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 3.98e-10 | 8.45e-01 | -0.0809 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ACOXL | SNV | Missense_Mutation | c.509N>T | p.Tyr170Phe | p.Y170F | Q9NUZ1 | protein_coding | tolerated(0.11) | benign(0.058) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
| ACOXL | SNV | Missense_Mutation | rs753215602 | c.231G>T | p.Trp77Cys | p.W77C | Q9NUZ1 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-A8-A09K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ACOXL | SNV | Missense_Mutation | novel | c.625N>C | p.Gly209Arg | p.G209R | Q9NUZ1 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AC-A3QP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
| ACOXL | SNV | Missense_Mutation | rs201679805 | c.548G>A | p.Gly183Asp | p.G183D | Q9NUZ1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A62X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ACOXL | SNV | Missense_Mutation | c.1406N>T | p.Cys469Phe | p.C469F | Q9NUZ1 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-AR-A0TW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | PD | |
| ACOXL | SNV | Missense_Mutation | rs763217979 | c.1070G>A | p.Arg357Gln | p.R357Q | Q9NUZ1 | protein_coding | tolerated(0.24) | benign(0.007) | TCGA-B6-A40B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ACOXL | SNV | Missense_Mutation | c.1666N>A | p.Phe556Ile | p.F556I | Q9NUZ1 | protein_coding | deleterious(0) | benign(0.12) | TCGA-BH-A18R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ACOXL | SNV | Missense_Mutation | rs768905536 | c.1732N>T | p.Ala578Ser | p.A578S | Q9NUZ1 | protein_coding | tolerated_low_confidence(0.12) | benign(0.196) | TCGA-E2-A153-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
| ACOXL | insertion | In_Frame_Ins | novel | c.68_69insCACACACACACAAATTAGCTGGGCATGGTGGTG | p.Gln23delinsHisThrHisThrGlnIleSerTrpAlaTrpTrpTrp | p.Q23delinsHTHTQISWAWWW | Q9NUZ1 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
| ACOXL | insertion | Nonsense_Mutation | novel | c.440_441insAGTACTACCCTATACTGACCACTCGTAAAGTGC | p.Ile147_Ile148insValLeuProTyrThrAspHisSerTerSerAla | p.I147_I148insVLPYTDHS*SA | Q9NUZ1 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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