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Gene: ACOT11 |
Gene summary for ACOT11 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ACOT11 | Gene ID | 26027 |
| Gene name | acyl-CoA thioesterase 11 | |
| Gene Alias | BFIT | |
| Cytomap | 1p32.3 | |
| Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | Q8WXI4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 26027 | ACOT11 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.37e-14 | 5.83e-01 | -0.1954 |
| 26027 | ACOT11 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.82e-07 | -3.64e-01 | 0.294 |
| 26027 | ACOT11 | F007 | Human | Colorectum | FAP | 2.34e-03 | -4.02e-01 | 0.1176 |
| 26027 | ACOT11 | A002-C-010 | Human | Colorectum | FAP | 1.08e-04 | -2.67e-01 | 0.242 |
| 26027 | ACOT11 | A001-C-207 | Human | Colorectum | FAP | 4.98e-03 | -2.09e-01 | 0.1278 |
| 26027 | ACOT11 | A015-C-203 | Human | Colorectum | FAP | 1.09e-27 | -3.23e-01 | -0.1294 |
| 26027 | ACOT11 | A015-C-204 | Human | Colorectum | FAP | 1.57e-04 | -2.83e-01 | -0.0228 |
| 26027 | ACOT11 | A014-C-040 | Human | Colorectum | FAP | 8.75e-03 | -2.29e-01 | -0.1184 |
| 26027 | ACOT11 | A002-C-201 | Human | Colorectum | FAP | 4.20e-10 | -2.56e-01 | 0.0324 |
| 26027 | ACOT11 | A002-C-203 | Human | Colorectum | FAP | 2.96e-04 | -1.67e-01 | 0.2786 |
| 26027 | ACOT11 | A001-C-119 | Human | Colorectum | FAP | 2.56e-12 | -5.24e-01 | -0.1557 |
| 26027 | ACOT11 | A001-C-108 | Human | Colorectum | FAP | 8.32e-15 | -2.53e-01 | -0.0272 |
| 26027 | ACOT11 | A002-C-205 | Human | Colorectum | FAP | 6.88e-22 | -5.09e-01 | -0.1236 |
| 26027 | ACOT11 | A001-C-104 | Human | Colorectum | FAP | 1.10e-02 | -1.32e-01 | 0.0184 |
| 26027 | ACOT11 | A015-C-005 | Human | Colorectum | FAP | 1.21e-02 | -2.59e-01 | -0.0336 |
| 26027 | ACOT11 | A015-C-006 | Human | Colorectum | FAP | 5.49e-14 | -4.33e-01 | -0.0994 |
| 26027 | ACOT11 | A015-C-106 | Human | Colorectum | FAP | 3.44e-10 | -2.11e-01 | -0.0511 |
| 26027 | ACOT11 | A002-C-114 | Human | Colorectum | FAP | 2.50e-17 | -3.33e-01 | -0.1561 |
| 26027 | ACOT11 | A015-C-104 | Human | Colorectum | FAP | 8.83e-30 | -4.75e-01 | -0.1899 |
| 26027 | ACOT11 | A001-C-014 | Human | Colorectum | FAP | 2.34e-17 | -3.96e-01 | 0.0135 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
| GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
| GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
| GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
| GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
| GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
| GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
| GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
| GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
| GO:0009409 | Colorectum | AD | response to cold | 22/3918 | 49/18723 | 1.40e-04 | 1.98e-03 | 22 |
| GO:0033865 | Colorectum | AD | nucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
| GO:0033875 | Colorectum | AD | ribonucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
| GO:0034032 | Colorectum | AD | purine nucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
| GO:0106106 | Colorectum | AD | cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
| GO:0120161 | Colorectum | AD | regulation of cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
| GO:1990845 | Colorectum | AD | adaptive thermogenesis | 46/3918 | 157/18723 | 7.97e-03 | 4.73e-02 | 46 |
| GO:00061632 | Colorectum | MSS | purine nucleotide metabolic process | 128/3467 | 396/18723 | 2.04e-11 | 3.02e-09 | 128 |
| GO:00091502 | Colorectum | MSS | purine ribonucleotide metabolic process | 121/3467 | 368/18723 | 2.08e-11 | 3.02e-09 | 121 |
| GO:00725212 | Colorectum | MSS | purine-containing compound metabolic process | 132/3467 | 416/18723 | 4.13e-11 | 4.86e-09 | 132 |
| GO:00092592 | Colorectum | MSS | ribonucleotide metabolic process | 123/3467 | 385/18723 | 1.17e-10 | 1.20e-08 | 123 |
| Page: 1 2 3 4 5 6 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ACOT11 | SNV | Missense_Mutation | rs138502889 | c.1556N>T | p.Thr519Met | p.T519M | Q8WXI4 | protein_coding | deleterious(0.05) | possibly_damaging(0.807) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ACOT11 | SNV | Missense_Mutation | c.539N>A | p.Arg180His | p.R180H | Q8WXI4 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ACOT11 | SNV | Missense_Mutation | c.457N>G | p.Arg153Gly | p.R153G | Q8WXI4 | protein_coding | tolerated(0.45) | benign(0.006) | TCGA-E2-A150-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| ACOT11 | SNV | Missense_Mutation | novel | c.1299N>G | p.His433Gln | p.H433Q | Q8WXI4 | protein_coding | tolerated(0.57) | benign(0) | TCGA-AA-3939-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| ACOT11 | SNV | Missense_Mutation | rs377475734 | c.1715G>A | p.Arg572His | p.R572H | Q8WXI4 | protein_coding | unknown(0) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| ACOT11 | SNV | Missense_Mutation | rs372914671 | c.88N>A | p.Gly30Arg | p.G30R | Q8WXI4 | protein_coding | deleterious_low_confidence(0.04) | benign(0.001) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ACOT11 | SNV | Missense_Mutation | rs144192149 | c.910G>A | p.Ala304Thr | p.A304T | Q8WXI4 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-CM-6165-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| ACOT11 | SNV | Missense_Mutation | novel | c.865A>G | p.Asn289Asp | p.N289D | Q8WXI4 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ACOT11 | SNV | Missense_Mutation | rs748574584 | c.904G>A | p.Val302Met | p.V302M | Q8WXI4 | protein_coding | deleterious(0.02) | possibly_damaging(0.907) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
| ACOT11 | SNV | Missense_Mutation | rs778640519 | c.1043G>A | p.Arg348Gln | p.R348Q | Q8WXI4 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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