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Gene: ACOT1 |
Gene summary for ACOT1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ACOT1 | Gene ID | 641371 |
| Gene name | acyl-CoA thioesterase 1 | |
| Gene Alias | ACH2 | |
| Cytomap | 14q24.3 | |
| Gene Type | protein-coding | GO ID | GO:0000038 | UniProtAcc | E9KL42 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 641371 | ACOT1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.23e-02 | 1.22e-01 | 0.0155 |
| 641371 | ACOT1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.79e-03 | 2.40e-01 | -0.1808 |
| 641371 | ACOT1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.01e-04 | 2.64e-01 | -0.0811 |
| 641371 | ACOT1 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.53e-08 | 2.69e-01 | -0.1088 |
| 641371 | ACOT1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.48e-14 | 3.67e-01 | -0.1954 |
| 641371 | ACOT1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.25e-03 | 4.37e-01 | -0.2602 |
| 641371 | ACOT1 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.76e-05 | 2.69e-01 | -0.1526 |
| 641371 | ACOT1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.35e-07 | 2.27e-01 | -0.1464 |
| 641371 | ACOT1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.07e-07 | 1.63e-01 | -0.1001 |
| 641371 | ACOT1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.07e-10 | 2.96e-01 | -0.059 |
| 641371 | ACOT1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.31e-03 | 2.57e-01 | -0.2061 |
| 641371 | ACOT1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.25e-04 | 2.59e-01 | -0.0842 |
| 641371 | ACOT1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.55e-03 | 1.64e-01 | 0.096 |
| 641371 | ACOT1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.03e-02 | 2.05e-01 | -0.0177 |
| 641371 | ACOT1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.00e-05 | 1.54e-01 | 0.0674 |
| 641371 | ACOT1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.29e-02 | 2.72e-01 | 0.0112 |
| 641371 | ACOT1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.17e-05 | 1.85e-01 | 0.294 |
| 641371 | ACOT1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.16e-05 | 2.55e-01 | 0.281 |
| 641371 | ACOT1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.62e-04 | 1.11e-01 | 0.3005 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
| GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
| GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
| GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
| GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
| GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
| GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
| GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
| GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
| GO:0009409 | Colorectum | AD | response to cold | 22/3918 | 49/18723 | 1.40e-04 | 1.98e-03 | 22 |
| GO:0033865 | Colorectum | AD | nucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
| GO:0033875 | Colorectum | AD | ribonucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
| GO:0034032 | Colorectum | AD | purine nucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
| GO:0106106 | Colorectum | AD | cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
| GO:0120161 | Colorectum | AD | regulation of cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
| GO:1990845 | Colorectum | AD | adaptive thermogenesis | 46/3918 | 157/18723 | 7.97e-03 | 4.73e-02 | 46 |
| GO:00061631 | Colorectum | SER | purine nucleotide metabolic process | 109/2897 | 396/18723 | 4.26e-10 | 5.44e-08 | 109 |
| GO:00091501 | Colorectum | SER | purine ribonucleotide metabolic process | 103/2897 | 368/18723 | 4.69e-10 | 5.68e-08 | 103 |
| GO:00725211 | Colorectum | SER | purine-containing compound metabolic process | 113/2897 | 416/18723 | 4.80e-10 | 5.68e-08 | 113 |
| GO:00092591 | Colorectum | SER | ribonucleotide metabolic process | 104/2897 | 385/18723 | 3.27e-09 | 3.04e-07 | 104 |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa00062 | Colorectum | SER | Fatty acid elongation | 11/1580 | 27/8465 | 6.38e-03 | 3.68e-02 | 2.67e-02 | 11 |
| hsa000621 | Colorectum | SER | Fatty acid elongation | 11/1580 | 27/8465 | 6.38e-03 | 3.68e-02 | 2.67e-02 | 11 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ACOT1 | SNV | Missense_Mutation | novel | c.1009G>A | p.Glu337Lys | p.E337K | Q86TX2 | protein_coding | tolerated(0.51) | benign(0.028) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
| ACOT1 | SNV | Missense_Mutation | rs778993401 | c.46N>A | p.Asp16Asn | p.D16N | Q86TX2 | protein_coding | deleterious(0.03) | probably_damaging(0.915) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
| ACOT1 | SNV | Missense_Mutation | c.689N>A | p.Gly230Glu | p.G230E | Q86TX2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ACOT1 | SNV | Missense_Mutation | novel | c.261N>T | p.Glu87Asp | p.E87D | Q86TX2 | protein_coding | tolerated(0.55) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| ACOT1 | SNV | Missense_Mutation | c.539N>T | p.Gly180Val | p.G180V | Q86TX2 | protein_coding | deleterious(0) | possibly_damaging(0.783) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
| ACOT1 | SNV | Missense_Mutation | rs757997047 | c.766G>A | p.Gly256Ser | p.G256S | Q86TX2 | protein_coding | tolerated(0.07) | possibly_damaging(0.893) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ACOT1 | SNV | Missense_Mutation | novel | c.1204C>T | p.Leu402Phe | p.L402F | Q86TX2 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ACOT1 | SNV | Missense_Mutation | rs753448518 | c.757G>A | p.Val253Ile | p.V253I | Q86TX2 | protein_coding | tolerated(0.59) | benign(0) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ACOT1 | SNV | Missense_Mutation | novel | c.999C>A | p.Phe333Leu | p.F333L | Q86TX2 | protein_coding | tolerated(0.69) | benign(0.018) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ACOT1 | SNV | Missense_Mutation | novel | c.781N>A | p.Val261Ile | p.V261I | Q86TX2 | protein_coding | tolerated(0.19) | benign(0.01) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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