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Gene: ACADL |
Gene summary for ACADL |
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Gene information | Species | Human | Gene symbol | ACADL | Gene ID | 33 |
Gene name | acyl-CoA dehydrogenase long chain | |
Gene Alias | ACAD4 | |
Cytomap | 2q34 | |
Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | P28330 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
33 | ACADL | male-WTA | Human | Thyroid | PTC | 2.89e-15 | 1.02e-01 | 0.1037 |
33 | ACADL | PTC01 | Human | Thyroid | PTC | 2.55e-13 | 8.02e-02 | 0.1899 |
33 | ACADL | PTC04 | Human | Thyroid | PTC | 7.66e-09 | 2.26e-01 | 0.1927 |
33 | ACADL | PTC05 | Human | Thyroid | PTC | 4.35e-13 | 3.87e-01 | 0.2065 |
33 | ACADL | PTC06 | Human | Thyroid | PTC | 5.45e-08 | 2.09e-01 | 0.2057 |
33 | ACADL | PTC07 | Human | Thyroid | PTC | 4.50e-20 | 3.05e-01 | 0.2044 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044270111 | Thyroid | PTC | cellular nitrogen compound catabolic process | 223/5968 | 451/18723 | 3.34e-15 | 2.31e-13 | 223 |
GO:000657513 | Thyroid | PTC | cellular modified amino acid metabolic process | 85/5968 | 188/18723 | 8.29e-05 | 7.01e-04 | 85 |
GO:010610613 | Thyroid | PTC | cold-induced thermogenesis | 61/5968 | 144/18723 | 5.08e-03 | 2.35e-02 | 61 |
GO:012016113 | Thyroid | PTC | regulation of cold-induced thermogenesis | 61/5968 | 144/18723 | 5.08e-03 | 2.35e-02 | 61 |
GO:199084513 | Thyroid | PTC | adaptive thermogenesis | 64/5968 | 157/18723 | 1.14e-02 | 4.50e-02 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACADL | SNV | Missense_Mutation | novel | c.202N>C | p.Phe68Leu | p.F68L | P28330 | protein_coding | tolerated(0.79) | possibly_damaging(0.493) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACADL | SNV | Missense_Mutation | rs374929072 | c.697T>C | p.Phe233Leu | p.F233L | P28330 | protein_coding | tolerated(0.56) | probably_damaging(0.997) | TCGA-AQ-A54N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACADL | SNV | Missense_Mutation | c.1218A>T | p.Arg406Ser | p.R406S | P28330 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A250-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ACADL | SNV | Missense_Mutation | c.1217G>C | p.Arg406Thr | p.R406T | P28330 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A250-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ACADL | insertion | Nonsense_Mutation | novel | c.1155_1156insAGTCTGTTTTAGTGATGGAGTCTCACCCA | p.Leu386SerfsTer4 | p.L386Sfs*4 | P28330 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
ACADL | SNV | Missense_Mutation | c.776N>T | p.Ala259Val | p.A259V | P28330 | protein_coding | deleterious(0.01) | possibly_damaging(0.548) | TCGA-4N-A93T-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | SD | |
ACADL | SNV | Missense_Mutation | novel | c.1178N>C | p.Met393Thr | p.M393T | P28330 | protein_coding | deleterious(0.01) | probably_damaging(0.971) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ACADL | SNV | Missense_Mutation | rs758491059 | c.149N>A | p.Arg50Gln | p.R50Q | P28330 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ACADL | SNV | Missense_Mutation | novel | c.589C>A | p.Leu197Ile | p.L197I | P28330 | protein_coding | tolerated(0.49) | possibly_damaging(0.766) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
ACADL | deletion | Frame_Shift_Del | c.751delA | p.Met251TrpfsTer3 | p.M251Wfs*3 | P28330 | protein_coding | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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