Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ABRAXAS2

Gene summary for ABRAXAS2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ABRAXAS2

Gene ID

23172

Gene nameabraxas 2, BRISC complex subunit
Gene AliasABRO1
Cytomap10q26.13
Gene Typeprotein-coding
GO ID

GO:0000226

UniProtAcc

Q15018


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
23172ABRAXAS2male-WTAHumanThyroidPTC2.76e-081.47e-010.1037
23172ABRAXAS2PTC01HumanThyroidPTC5.14e-039.04e-020.1899
23172ABRAXAS2PTC04HumanThyroidPTC1.15e-031.20e-010.1927
23172ABRAXAS2PTC05HumanThyroidPTC3.72e-103.54e-010.2065
23172ABRAXAS2PTC06HumanThyroidPTC1.25e-133.30e-010.2057
23172ABRAXAS2PTC07HumanThyroidPTC1.68e-152.67e-010.2044
23172ABRAXAS2ATC12HumanThyroidATC1.09e-021.17e-010.34
23172ABRAXAS2ATC13HumanThyroidATC1.24e-092.38e-010.34
23172ABRAXAS2ATC2HumanThyroidATC9.94e-095.69e-010.34
23172ABRAXAS2ATC4HumanThyroidATC1.40e-021.20e-010.34
23172ABRAXAS2ATC5HumanThyroidATC1.04e-122.58e-010.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:01400148ThyroidPTCmitotic nuclear division135/5968287/187234.90e-081.04e-06135
GO:000705116ThyroidPTCspindle organization92/5968184/187232.21e-073.92e-0692
GO:19028509ThyroidPTCmicrotubule cytoskeleton organization involved in mitosis76/5968147/187234.49e-077.38e-0676
GO:000705216ThyroidPTCmitotic spindle organization64/5968120/187238.69e-071.32e-0564
GO:00070595ThyroidPTCchromosome segregation146/5968346/187232.99e-052.87e-04146
GO:005122514ThyroidPTCspindle assembly56/5968117/187232.17e-041.60e-0356
GO:00706465ThyroidPTCprotein modification by small protein removal71/5968157/187233.03e-042.12e-0371
GO:00029314ThyroidPTCresponse to ischemia31/596858/187235.31e-043.41e-0331
GO:00482855ThyroidPTCorganelle fission188/5968488/187239.64e-045.77e-03188
GO:009030717ThyroidPTCmitotic spindle assembly33/596865/187231.17e-036.81e-0333
GO:00988135ThyroidPTCnuclear chromosome segregation114/5968281/187231.21e-036.94e-03114
GO:00705363ThyroidPTCprotein K63-linked deubiquitination20/596835/187231.75e-039.51e-0320
GO:00002804ThyroidPTCnuclear division167/5968439/187233.27e-031.60e-02167
GO:00165794ThyroidPTCprotein deubiquitination59/5968139/187235.50e-032.50e-0259
GO:014001416ThyroidATCmitotic nuclear division171/6293287/187231.13e-191.66e-17171
GO:190285017ThyroidATCmicrotubule cytoskeleton organization involved in mitosis95/6293147/187231.29e-147.62e-1395
GO:000705913ThyroidATCchromosome segregation183/6293346/187238.03e-144.23e-12183
GO:000705222ThyroidATCmitotic spindle organization80/6293120/187231.27e-136.46e-1280
GO:000705122ThyroidATCspindle organization109/6293184/187237.99e-133.46e-11109
GO:009881312ThyroidATCnuclear chromosome segregation145/6293281/187233.06e-108.61e-09145
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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