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Gene: ABHD3 |
Gene summary for ABHD3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ABHD3 | Gene ID | 171586 |
Gene name | abhydrolase domain containing 3, phospholipase | |
Gene Alias | LABH3 | |
Cytomap | 18q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | J3KTE1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
171586 | ABHD3 | CCI_1 | Human | Cervix | CC | 4.92e-05 | 9.10e-01 | 0.528 |
171586 | ABHD3 | CCI_3 | Human | Cervix | CC | 1.76e-05 | 6.00e-01 | 0.516 |
171586 | ABHD3 | T1 | Human | Cervix | CC | 1.06e-05 | 3.96e-01 | 0.0918 |
171586 | ABHD3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.73e-04 | 4.19e-01 | -0.1808 |
171586 | ABHD3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.06e-04 | 6.12e-01 | -0.0811 |
171586 | ABHD3 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.19e-10 | 4.92e-01 | -0.1954 |
171586 | ABHD3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.20e-03 | 9.44e-01 | -0.2602 |
171586 | ABHD3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.80e-02 | 4.38e-01 | -0.059 |
171586 | ABHD3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.54e-11 | -5.00e-01 | 0.3859 |
171586 | ABHD3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.21e-15 | -5.42e-01 | 0.3005 |
171586 | ABHD3 | A002-C-010 | Human | Colorectum | FAP | 1.30e-03 | 2.50e-01 | 0.242 |
171586 | ABHD3 | A015-C-203 | Human | Colorectum | FAP | 1.09e-15 | -3.32e-01 | -0.1294 |
171586 | ABHD3 | A015-C-204 | Human | Colorectum | FAP | 1.54e-02 | -2.89e-01 | -0.0228 |
171586 | ABHD3 | A002-C-201 | Human | Colorectum | FAP | 2.46e-05 | -1.90e-01 | 0.0324 |
171586 | ABHD3 | A001-C-119 | Human | Colorectum | FAP | 6.01e-07 | -4.83e-01 | -0.1557 |
171586 | ABHD3 | A001-C-108 | Human | Colorectum | FAP | 3.70e-10 | -2.52e-01 | -0.0272 |
171586 | ABHD3 | A002-C-205 | Human | Colorectum | FAP | 1.41e-13 | -4.72e-01 | -0.1236 |
171586 | ABHD3 | A015-C-006 | Human | Colorectum | FAP | 9.81e-11 | -5.49e-01 | -0.0994 |
171586 | ABHD3 | A015-C-106 | Human | Colorectum | FAP | 2.10e-06 | -2.82e-01 | -0.0511 |
171586 | ABHD3 | A002-C-114 | Human | Colorectum | FAP | 3.40e-08 | -3.20e-01 | -0.1561 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0009062 | Colorectum | AD | fatty acid catabolic process | 41/3918 | 100/18723 | 4.02e-06 | 1.09e-04 | 41 |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0072329 | Colorectum | AD | monocarboxylic acid catabolic process | 44/3918 | 122/18723 | 8.05e-05 | 1.28e-03 | 44 |
GO:0016054 | Colorectum | AD | organic acid catabolic process | 73/3918 | 240/18723 | 3.20e-04 | 3.81e-03 | 73 |
GO:0044242 | Colorectum | AD | cellular lipid catabolic process | 66/3918 | 214/18723 | 3.96e-04 | 4.50e-03 | 66 |
GO:0046395 | Colorectum | AD | carboxylic acid catabolic process | 70/3918 | 236/18723 | 9.06e-04 | 8.71e-03 | 70 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:00160421 | Colorectum | SER | lipid catabolic process | 77/2897 | 320/18723 | 3.52e-05 | 9.18e-04 | 77 |
GO:00442821 | Colorectum | SER | small molecule catabolic process | 87/2897 | 376/18723 | 5.31e-05 | 1.27e-03 | 87 |
GO:00090621 | Colorectum | SER | fatty acid catabolic process | 31/2897 | 100/18723 | 7.09e-05 | 1.61e-03 | 31 |
GO:00723291 | Colorectum | SER | monocarboxylic acid catabolic process | 34/2897 | 122/18723 | 3.27e-04 | 5.22e-03 | 34 |
GO:00442421 | Colorectum | SER | cellular lipid catabolic process | 51/2897 | 214/18723 | 8.60e-04 | 1.05e-02 | 51 |
GO:0046486 | Colorectum | SER | glycerolipid metabolic process | 82/2897 | 392/18723 | 2.26e-03 | 2.17e-02 | 82 |
GO:00066441 | Colorectum | SER | phospholipid metabolic process | 79/2897 | 383/18723 | 3.94e-03 | 3.24e-02 | 79 |
GO:00160541 | Colorectum | SER | organic acid catabolic process | 53/2897 | 240/18723 | 4.04e-03 | 3.30e-02 | 53 |
GO:00450171 | Colorectum | SER | glycerolipid biosynthetic process | 55/2897 | 252/18723 | 4.47e-03 | 3.56e-02 | 55 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABHD3 | SNV | Missense_Mutation | c.926N>T | p.Thr309Ile | p.T309I | Q8WU67 | protein_coding | deleterious(0.04) | possibly_damaging(0.702) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ABHD3 | SNV | Missense_Mutation | c.189N>T | p.Glu63Asp | p.E63D | Q8WU67 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ABHD3 | SNV | Missense_Mutation | c.74N>A | p.Val25Glu | p.V25E | Q8WU67 | protein_coding | tolerated(0.1) | benign(0.007) | TCGA-AF-A56L-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ABHD3 | SNV | Missense_Mutation | c.1073C>T | p.Thr358Ile | p.T358I | Q8WU67 | protein_coding | tolerated(0.12) | benign(0.021) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ABHD3 | SNV | Missense_Mutation | c.469A>C | p.Ile157Leu | p.I157L | Q8WU67 | protein_coding | deleterious(0.02) | possibly_damaging(0.53) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ABHD3 | SNV | Missense_Mutation | novel | c.448N>A | p.Gly150Arg | p.G150R | Q8WU67 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABHD3 | SNV | Missense_Mutation | novel | c.448N>A | p.Gly150Arg | p.G150R | Q8WU67 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABHD3 | SNV | Missense_Mutation | novel | c.662N>C | p.Met221Thr | p.M221T | Q8WU67 | protein_coding | deleterious(0) | possibly_damaging(0.864) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABHD3 | SNV | Missense_Mutation | c.842N>G | p.Lys281Arg | p.K281R | Q8WU67 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABHD3 | SNV | Missense_Mutation | novel | c.223N>A | p.Val75Met | p.V75M | Q8WU67 | protein_coding | deleterious(0.03) | benign(0.371) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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