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Gene: ABHD18 |
Gene summary for ABHD18 |
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Gene information | Species | Human | Gene symbol | ABHD18 | Gene ID | 80167 |
Gene name | abhydrolase domain containing 18 | |
Gene Alias | C4orf29 | |
Cytomap | 4q28.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B7WP89 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80167 | ABHD18 | CCI_1 | Human | Cervix | CC | 1.53e-07 | 7.02e-01 | 0.528 |
80167 | ABHD18 | CCI_3 | Human | Cervix | CC | 9.67e-05 | 5.64e-01 | 0.516 |
80167 | ABHD18 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.05e-03 | 5.09e-01 | -0.0811 |
80167 | ABHD18 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.39e-12 | 6.31e-01 | -0.1954 |
80167 | ABHD18 | F007 | Human | Colorectum | FAP | 1.23e-02 | -2.41e-01 | 0.1176 |
80167 | ABHD18 | A001-C-207 | Human | Colorectum | FAP | 1.10e-03 | -2.51e-01 | 0.1278 |
80167 | ABHD18 | A015-C-203 | Human | Colorectum | FAP | 8.46e-22 | -3.71e-01 | -0.1294 |
80167 | ABHD18 | A015-C-204 | Human | Colorectum | FAP | 1.30e-05 | -2.01e-01 | -0.0228 |
80167 | ABHD18 | A014-C-040 | Human | Colorectum | FAP | 2.59e-03 | -3.41e-01 | -0.1184 |
80167 | ABHD18 | A002-C-201 | Human | Colorectum | FAP | 1.12e-12 | -3.59e-01 | 0.0324 |
80167 | ABHD18 | A002-C-203 | Human | Colorectum | FAP | 2.02e-03 | -1.98e-01 | 0.2786 |
80167 | ABHD18 | A001-C-119 | Human | Colorectum | FAP | 2.02e-06 | -3.29e-01 | -0.1557 |
80167 | ABHD18 | A001-C-108 | Human | Colorectum | FAP | 1.27e-13 | -2.32e-01 | -0.0272 |
80167 | ABHD18 | A002-C-205 | Human | Colorectum | FAP | 8.13e-19 | -2.01e-01 | -0.1236 |
80167 | ABHD18 | A001-C-104 | Human | Colorectum | FAP | 4.48e-04 | -2.28e-01 | 0.0184 |
80167 | ABHD18 | A015-C-005 | Human | Colorectum | FAP | 3.06e-03 | -1.51e-01 | -0.0336 |
80167 | ABHD18 | A015-C-006 | Human | Colorectum | FAP | 2.49e-14 | -3.73e-01 | -0.0994 |
80167 | ABHD18 | A015-C-106 | Human | Colorectum | FAP | 5.95e-09 | -2.15e-01 | -0.0511 |
80167 | ABHD18 | A002-C-114 | Human | Colorectum | FAP | 2.99e-16 | -2.72e-01 | -0.1561 |
80167 | ABHD18 | A015-C-104 | Human | Colorectum | FAP | 6.42e-21 | -3.16e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABHD18 | SNV | Missense_Mutation | rs765230932 | c.1198N>C | p.Gly400Arg | p.G400R | Q0P651 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A2-A0YC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | PD |
ABHD18 | insertion | Frame_Shift_Ins | novel | c.250_251insATCATCAATCTATTCT | p.Ile84AsnfsTer10 | p.I84Nfs*10 | Q0P651 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ABHD18 | SNV | Missense_Mutation | c.344N>A | p.Gly115Glu | p.G115E | Q0P651 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ABHD18 | SNV | Missense_Mutation | c.796N>G | p.Leu266Val | p.L266V | Q0P651 | protein_coding | tolerated(0.51) | benign(0.018) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ABHD18 | SNV | Missense_Mutation | c.1064T>C | p.Val355Ala | p.V355A | Q0P651 | protein_coding | deleterious(0) | benign(0.416) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ABHD18 | SNV | Missense_Mutation | c.374G>A | p.Arg125Gln | p.R125Q | Q0P651 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ABHD18 | SNV | Missense_Mutation | rs761660121 | c.623C>T | p.Ala208Val | p.A208V | Q0P651 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ABHD18 | SNV | Missense_Mutation | c.893A>G | p.Gln298Arg | p.Q298R | Q0P651 | protein_coding | tolerated(0.23) | benign(0.022) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABHD18 | SNV | Missense_Mutation | c.536C>T | p.Ala179Val | p.A179V | Q0P651 | protein_coding | tolerated(0.44) | possibly_damaging(0.589) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ABHD18 | SNV | Missense_Mutation | novel | c.755A>G | p.Asp252Gly | p.D252G | Q0P651 | protein_coding | tolerated(0.05) | probably_damaging(0.966) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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