![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ABHD11 |
Gene summary for ABHD11 |
![]() |
Gene information | Species | Human | Gene symbol | ABHD11 | Gene ID | 83451 |
Gene name | abhydrolase domain containing 11 | |
Gene Alias | PP1226 | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q8NFV4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83451 | ABHD11 | GSM4909293 | Human | Breast | IDC | 1.30e-13 | 2.96e-01 | 0.1581 |
83451 | ABHD11 | GSM4909296 | Human | Breast | IDC | 2.53e-03 | 2.94e-01 | 0.1524 |
83451 | ABHD11 | GSM4909298 | Human | Breast | IDC | 4.56e-05 | 1.75e-01 | 0.1551 |
83451 | ABHD11 | GSM4909305 | Human | Breast | IDC | 1.75e-03 | 3.01e-01 | 0.0436 |
83451 | ABHD11 | GSM4909306 | Human | Breast | IDC | 3.39e-31 | 6.92e-01 | 0.1564 |
83451 | ABHD11 | GSM4909311 | Human | Breast | IDC | 3.79e-02 | -1.28e-01 | 0.1534 |
83451 | ABHD11 | GSM4909317 | Human | Breast | IDC | 6.63e-13 | 4.62e-01 | 0.1355 |
83451 | ABHD11 | GSM4909318 | Human | Breast | IDC | 2.91e-04 | 5.42e-01 | 0.2031 |
83451 | ABHD11 | GSM4909319 | Human | Breast | IDC | 1.33e-02 | -4.00e-02 | 0.1563 |
83451 | ABHD11 | GSM4909321 | Human | Breast | IDC | 3.49e-14 | 5.16e-01 | 0.1559 |
83451 | ABHD11 | brca2 | Human | Breast | Precancer | 2.46e-06 | 2.08e-01 | -0.024 |
83451 | ABHD11 | brca3 | Human | Breast | Precancer | 9.04e-07 | 1.80e-01 | -0.0263 |
83451 | ABHD11 | DCIS2 | Human | Breast | DCIS | 6.52e-40 | 9.04e-02 | 0.0085 |
83451 | ABHD11 | LZE4T | Human | Esophagus | ESCC | 5.00e-04 | 1.75e-01 | 0.0811 |
83451 | ABHD11 | LZE5T | Human | Esophagus | ESCC | 1.81e-08 | 8.62e-01 | 0.0514 |
83451 | ABHD11 | LZE7T | Human | Esophagus | ESCC | 5.38e-08 | 4.49e-01 | 0.0667 |
83451 | ABHD11 | LZE8T | Human | Esophagus | ESCC | 1.85e-07 | 2.21e-01 | 0.067 |
83451 | ABHD11 | LZE20T | Human | Esophagus | ESCC | 4.16e-03 | 2.66e-01 | 0.0662 |
83451 | ABHD11 | LZE22T | Human | Esophagus | ESCC | 9.82e-05 | 7.70e-01 | 0.068 |
83451 | ABHD11 | LZE24T | Human | Esophagus | ESCC | 8.38e-23 | 1.21e+00 | 0.0596 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABHD11 | SNV | Missense_Mutation | novel | c.431G>T | p.Gly144Val | p.G144V | Q8NFV4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C8-A12U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABHD11 | SNV | Missense_Mutation | c.668T>C | p.Leu223Pro | p.L223P | Q8NFV4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ABHD11 | SNV | Missense_Mutation | novel | c.134N>A | p.Arg45Gln | p.R45Q | Q8NFV4 | protein_coding | tolerated(0.47) | benign(0) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ABHD11 | SNV | Missense_Mutation | novel | c.508N>A | p.Glu170Lys | p.E170K | Q8NFV4 | protein_coding | tolerated(0.65) | benign(0.001) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ABHD11 | deletion | Frame_Shift_Del | novel | c.140delN | p.Gly47AlafsTer52 | p.G47Afs*52 | Q8NFV4 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
ABHD11 | SNV | Missense_Mutation | c.211N>G | p.Phe71Val | p.F71V | Q8NFV4 | protein_coding | tolerated(0.13) | benign(0.028) | TCGA-AY-A54L-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ABHD11 | SNV | Missense_Mutation | c.531T>A | p.Phe177Leu | p.F177L | Q8NFV4 | protein_coding | tolerated(0.19) | benign(0.006) | TCGA-D5-6534-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ABHD11 | SNV | Missense_Mutation | novel | c.715N>A | p.Leu239Met | p.L239M | Q8NFV4 | protein_coding | deleterious(0.03) | probably_damaging(0.979) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
ABHD11 | SNV | Missense_Mutation | novel | c.493G>T | p.Asp165Tyr | p.D165Y | Q8NFV4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABHD11 | SNV | Missense_Mutation | novel | c.653N>G | p.His218Arg | p.H218R | Q8NFV4 | protein_coding | deleterious(0) | benign(0) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |