![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ABCC4 |
Gene summary for ABCC4 |
![]() |
Gene information | Species | Human | Gene symbol | ABCC4 | Gene ID | 10257 |
Gene name | ATP binding cassette subfamily C member 4 | |
Gene Alias | MOAT-B | |
Cytomap | 13q32.1 | |
Gene Type | protein-coding | GO ID | GO:0001408 | UniProtAcc | A8K2Q2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10257 | ABCC4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.38e-09 | -4.10e-01 | 0.0155 |
10257 | ABCC4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.66e-06 | -4.57e-01 | -0.1808 |
10257 | ABCC4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.87e-07 | -5.48e-01 | -0.0811 |
10257 | ABCC4 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.71e-05 | -4.25e-01 | -0.1088 |
10257 | ABCC4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.09e-03 | -4.58e-01 | -0.1207 |
10257 | ABCC4 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.56e-04 | -5.17e-01 | -0.1526 |
10257 | ABCC4 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.82e-03 | -3.18e-01 | -0.1464 |
10257 | ABCC4 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.65e-07 | -4.13e-01 | -0.1001 |
10257 | ABCC4 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.76e-08 | -4.32e-01 | 0.096 |
10257 | ABCC4 | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.20e-06 | -4.83e-01 | 0.0338 |
10257 | ABCC4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.18e-02 | -2.70e-01 | 0.0674 |
10257 | ABCC4 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.54e-03 | -4.68e-01 | 0.0588 |
10257 | ABCC4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.47e-07 | -3.61e-01 | 0.294 |
10257 | ABCC4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.15e-02 | -4.24e-01 | 0.281 |
10257 | ABCC4 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.64e-04 | -5.12e-01 | 0.2585 |
10257 | ABCC4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.48e-02 | -2.66e-01 | 0.3005 |
10257 | ABCC4 | F007 | Human | Colorectum | FAP | 8.96e-06 | -3.97e-01 | 0.1176 |
10257 | ABCC4 | A002-C-010 | Human | Colorectum | FAP | 2.38e-06 | -3.35e-01 | 0.242 |
10257 | ABCC4 | A001-C-207 | Human | Colorectum | FAP | 1.43e-11 | -4.50e-01 | 0.1278 |
10257 | ABCC4 | A015-C-203 | Human | Colorectum | FAP | 5.48e-27 | -5.62e-01 | -0.1294 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0015931 | Colorectum | AD | nucleobase-containing compound transport | 73/3918 | 222/18723 | 2.02e-05 | 4.10e-04 | 73 |
GO:0009410 | Colorectum | AD | response to xenobiotic stimulus | 128/3918 | 462/18723 | 2.69e-04 | 3.31e-03 | 128 |
GO:0015833 | Colorectum | AD | peptide transport | 77/3918 | 264/18723 | 8.90e-04 | 8.60e-03 | 77 |
GO:0015732 | Colorectum | AD | prostaglandin transport | 10/3918 | 18/18723 | 1.31e-03 | 1.15e-02 | 10 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:0032310 | Colorectum | AD | prostaglandin secretion | 8/3918 | 15/18723 | 5.67e-03 | 3.64e-02 | 8 |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:00159311 | Colorectum | SER | nucleobase-containing compound transport | 54/2897 | 222/18723 | 3.65e-04 | 5.67e-03 | 54 |
GO:00068871 | Colorectum | SER | exocytosis | 75/2897 | 352/18723 | 2.05e-03 | 2.03e-02 | 75 |
GO:00158331 | Colorectum | SER | peptide transport | 58/2897 | 264/18723 | 3.08e-03 | 2.70e-02 | 58 |
GO:00159312 | Colorectum | MSS | nucleobase-containing compound transport | 70/3467 | 222/18723 | 1.92e-06 | 6.01e-05 | 70 |
GO:00158332 | Colorectum | MSS | peptide transport | 71/3467 | 264/18723 | 4.79e-04 | 5.60e-03 | 71 |
GO:0150104 | Colorectum | MSS | transport across blood-brain barrier | 28/3467 | 87/18723 | 1.54e-03 | 1.41e-02 | 28 |
GO:0010232 | Colorectum | MSS | vascular transport | 28/3467 | 88/18723 | 1.87e-03 | 1.64e-02 | 28 |
GO:00428861 | Colorectum | MSS | amide transport | 76/3467 | 301/18723 | 2.14e-03 | 1.80e-02 | 76 |
GO:00094101 | Colorectum | MSS | response to xenobiotic stimulus | 110/3467 | 462/18723 | 2.36e-03 | 1.92e-02 | 110 |
Page: 1 2 3 4 5 6 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01523 | Liver | HCC | Antifolate resistance | 21/4020 | 30/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 21 |
hsa020102 | Liver | HCC | ABC transporters | 29/4020 | 45/8465 | 1.62e-02 | 3.88e-02 | 2.16e-02 | 29 |
hsa015231 | Liver | HCC | Antifolate resistance | 21/4020 | 30/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 21 |
hsa020103 | Liver | HCC | ABC transporters | 29/4020 | 45/8465 | 1.62e-02 | 3.88e-02 | 2.16e-02 | 29 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABCC4 | SNV | Missense_Mutation | novel | c.3144N>A | p.Phe1048Leu | p.F1048L | O15439 | protein_coding | tolerated(0.35) | benign(0.05) | TCGA-A7-A6VV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
ABCC4 | SNV | Missense_Mutation | rs199702034 | c.2470N>T | p.Arg824Cys | p.R824C | O15439 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ABCC4 | SNV | Missense_Mutation | rs775555726 | c.137N>T | p.Ser46Leu | p.S46L | O15439 | protein_coding | tolerated(0.06) | benign(0.009) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ABCC4 | SNV | Missense_Mutation | c.3493N>G | p.Lys1165Glu | p.K1165E | O15439 | protein_coding | tolerated(0.07) | possibly_damaging(0.513) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ABCC4 | SNV | Missense_Mutation | novel | c.2732N>C | p.Leu911Pro | p.L911P | O15439 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AC-A3W5-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
ABCC4 | SNV | Missense_Mutation | c.707N>T | p.Ser236Leu | p.S236L | O15439 | protein_coding | deleterious(0) | possibly_damaging(0.842) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABCC4 | SNV | Missense_Mutation | c.3314N>A | p.Thr1105Lys | p.T1105K | O15439 | protein_coding | deleterious(0.01) | possibly_damaging(0.906) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
ABCC4 | SNV | Missense_Mutation | c.3569C>A | p.Ala1190Glu | p.A1190E | O15439 | protein_coding | deleterious(0.02) | possibly_damaging(0.654) | TCGA-BH-A0C7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
ABCC4 | SNV | Missense_Mutation | novel | c.1642N>A | p.Ala548Thr | p.A548T | O15439 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABCC4 | SNV | Missense_Mutation | novel | c.3364N>G | p.Gln1122Glu | p.Q1122E | O15439 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A132-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10257 | ABCC4 | ABC TRANSPORTER, DRUGGABLE GENOME, TRANSPORTER | inhibitor | 252827460 | ||
10257 | ABCC4 | ABC TRANSPORTER, DRUGGABLE GENOME, TRANSPORTER | CEFMETAZOLE | CEFMETAZOLE | 22166395 | |
10257 | ABCC4 | ABC TRANSPORTER, DRUGGABLE GENOME, TRANSPORTER | zidovudine | ZIDOVUDINE | 22960662,16791115 | |
10257 | ABCC4 | ABC TRANSPORTER, DRUGGABLE GENOME, TRANSPORTER | LEUCOVORIN | LEUCOVORIN | 12036927 | |
10257 | ABCC4 | ABC TRANSPORTER, DRUGGABLE GENOME, TRANSPORTER | MTX | METHOTREXATE | 12036927 | |
10257 | ABCC4 | ABC TRANSPORTER, DRUGGABLE GENOME, TRANSPORTER | Bisphosphonates | |||
10257 | ABCC4 | ABC TRANSPORTER, DRUGGABLE GENOME, TRANSPORTER | CEFUROXIME | CEFUROXIME | 22166395 | |
10257 | ABCC4 | ABC TRANSPORTER, DRUGGABLE GENOME, TRANSPORTER | lamivudine | LAMIVUDINE | ||
10257 | ABCC4 | ABC TRANSPORTER, DRUGGABLE GENOME, TRANSPORTER | CISPLATIN | CISPLATIN | 9270026 | |
10257 | ABCC4 | ABC TRANSPORTER, DRUGGABLE GENOME, TRANSPORTER | ANTIVIRAL | 12105214 |
Page: 1 2 3 4 |