GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00194396 | Liver | NAFLD | aromatic compound catabolic process | 102/1882 | 467/18723 | 2.29e-14 | 1.91e-11 | 102 |
GO:19013616 | Liver | NAFLD | organic cyclic compound catabolic process | 105/1882 | 495/18723 | 7.04e-14 | 5.15e-11 | 105 |
GO:00442707 | Liver | NAFLD | cellular nitrogen compound catabolic process | 93/1882 | 451/18723 | 1.04e-11 | 4.34e-09 | 93 |
GO:00467006 | Liver | NAFLD | heterocycle catabolic process | 92/1882 | 445/18723 | 1.16e-11 | 4.52e-09 | 92 |
GO:00485457 | Liver | NAFLD | response to steroid hormone | 75/1882 | 339/18723 | 3.44e-11 | 1.12e-08 | 75 |
GO:00094107 | Liver | NAFLD | response to xenobiotic stimulus | 88/1882 | 462/18723 | 2.53e-09 | 4.11e-07 | 88 |
GO:00713836 | Liver | NAFLD | cellular response to steroid hormone stimulus | 48/1882 | 204/18723 | 1.50e-08 | 1.83e-06 | 48 |
GO:00434346 | Liver | NAFLD | response to peptide hormone | 76/1882 | 414/18723 | 1.51e-07 | 1.09e-05 | 76 |
GO:00513846 | Liver | NAFLD | response to glucocorticoid | 36/1882 | 148/18723 | 3.88e-07 | 2.52e-05 | 36 |
GO:00108765 | Liver | NAFLD | lipid localization | 79/1882 | 448/18723 | 4.75e-07 | 2.92e-05 | 79 |
GO:00069797 | Liver | NAFLD | response to oxidative stress | 78/1882 | 446/18723 | 7.85e-07 | 4.29e-05 | 78 |
GO:00068694 | Liver | NAFLD | lipid transport | 71/1882 | 398/18723 | 1.16e-06 | 5.59e-05 | 71 |
GO:00319606 | Liver | NAFLD | response to corticosteroid | 37/1882 | 167/18723 | 3.03e-06 | 1.23e-04 | 37 |
GO:00713854 | Liver | NAFLD | cellular response to glucocorticoid stimulus | 17/1882 | 56/18723 | 2.17e-05 | 6.02e-04 | 17 |
GO:00067904 | Liver | NAFLD | sulfur compound metabolic process | 58/1882 | 339/18723 | 3.79e-05 | 9.38e-04 | 58 |
GO:00100387 | Liver | NAFLD | response to metal ion | 62/1882 | 373/18723 | 5.05e-05 | 1.19e-03 | 62 |
GO:0015850 | Liver | NAFLD | organic hydroxy compound transport | 50/1882 | 284/18723 | 6.01e-05 | 1.32e-03 | 50 |
GO:00715493 | Liver | NAFLD | cellular response to dexamethasone stimulus | 11/1882 | 29/18723 | 6.39e-05 | 1.39e-03 | 11 |
GO:00715483 | Liver | NAFLD | response to dexamethasone | 13/1882 | 39/18723 | 6.78e-05 | 1.45e-03 | 13 |
GO:00713844 | Liver | NAFLD | cellular response to corticosteroid stimulus | 17/1882 | 61/18723 | 7.31e-05 | 1.52e-03 | 17 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABCC2 | SNV | Missense_Mutation | | c.1815N>C | p.Gln605His | p.Q605H | Q92887 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-A2-A0YH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ABCC2 | SNV | Missense_Mutation | rs748245551 | c.412N>A | p.Leu138Ile | p.L138I | Q92887 | protein_coding | tolerated(0.11) | benign(0.266) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABCC2 | SNV | Missense_Mutation | rs754646220 | c.4285N>A | p.Glu1429Lys | p.E1429K | Q92887 | protein_coding | deleterious(0.02) | probably_damaging(0.916) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABCC2 | SNV | Missense_Mutation | rs759540575 | c.4585N>C | p.Tyr1529His | p.Y1529H | Q92887 | protein_coding | deleterious(0.05) | possibly_damaging(0.778) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ABCC2 | SNV | Missense_Mutation | rs754646220 | c.4285N>A | p.Glu1429Lys | p.E1429K | Q92887 | protein_coding | deleterious(0.02) | probably_damaging(0.916) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABCC2 | SNV | Missense_Mutation | rs377550597 | c.3436N>T | p.Arg1146Cys | p.R1146C | Q92887 | protein_coding | deleterious(0.05) | probably_damaging(1) | TCGA-AR-A0U3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ABCC2 | SNV | Missense_Mutation | | c.1590G>C | p.Lys530Asn | p.K530N | Q92887 | protein_coding | tolerated(0.37) | benign(0.093) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
ABCC2 | SNV | Missense_Mutation | rs751269660 | c.3806T>G | p.Val1269Gly | p.V1269G | Q92887 | protein_coding | deleterious(0) | possibly_damaging(0.703) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
ABCC2 | SNV | Missense_Mutation | novel | c.2008A>G | p.Ile670Val | p.I670V | Q92887 | protein_coding | tolerated(1) | benign(0) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
ABCC2 | SNV | Missense_Mutation | | c.3610A>T | p.Asn1204Tyr | p.N1204Y | Q92887 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1244 | ABCC2 | TRANSPORTER, DRUGGABLE GENOME, ABC TRANSPORTER, CELL SURFACE | | tamoxifen | TAMOXIFEN | |
1244 | ABCC2 | TRANSPORTER, DRUGGABLE GENOME, ABC TRANSPORTER, CELL SURFACE | | doxorubicin | DOXORUBICIN | 16330681 |
1244 | ABCC2 | TRANSPORTER, DRUGGABLE GENOME, ABC TRANSPORTER, CELL SURFACE | | mycophenolic acid | | 25163792,28624888 |
1244 | ABCC2 | TRANSPORTER, DRUGGABLE GENOME, ABC TRANSPORTER, CELL SURFACE | | SN-38 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | |
1244 | ABCC2 | TRANSPORTER, DRUGGABLE GENOME, ABC TRANSPORTER, CELL SURFACE | | Drugs For Treatment Of Tuberculosis | | 31648372 |
1244 | ABCC2 | TRANSPORTER, DRUGGABLE GENOME, ABC TRANSPORTER, CELL SURFACE | | deferasirox | DEFERASIROX | 25348619,26403473 |
1244 | ABCC2 | TRANSPORTER, DRUGGABLE GENOME, ABC TRANSPORTER, CELL SURFACE | | CEFACLOR | CEFACLOR | 22166395 |
1244 | ABCC2 | TRANSPORTER, DRUGGABLE GENOME, ABC TRANSPORTER, CELL SURFACE | | ritonavir | RITONAVIR | 26287941 |
1244 | ABCC2 | TRANSPORTER, DRUGGABLE GENOME, ABC TRANSPORTER, CELL SURFACE | | pravastatin | PRAVASTATIN | 17047488 |
1244 | ABCC2 | TRANSPORTER, DRUGGABLE GENOME, ABC TRANSPORTER, CELL SURFACE | | methotrexate | METHOTREXATE | 27217051,24241962,29791011,23069858,25502615,23222202,21317831,18381794 |