Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ABCB8

Gene summary for ABCB8

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ABCB8

Gene ID

11194

Gene nameATP binding cassette subfamily B member 8
Gene AliasEST328128
Cytomap7q36.1
Gene Typeprotein-coding
GO ID

GO:0006810

UniProtAcc

Q9NUT2


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
11194ABCB8LZE2THumanEsophagusESCC1.53e-075.48e-010.082
11194ABCB8LZE7THumanEsophagusESCC4.39e-021.63e-010.0667
11194ABCB8LZE8THumanEsophagusESCC3.70e-031.76e-010.067
11194ABCB8LZE20THumanEsophagusESCC4.88e-021.17e-010.0662
11194ABCB8LZE24THumanEsophagusESCC3.12e-102.65e-010.0596
11194ABCB8P1T-EHumanEsophagusESCC4.40e-042.09e-010.0875
11194ABCB8P2T-EHumanEsophagusESCC2.06e-081.81e-010.1177
11194ABCB8P4T-EHumanEsophagusESCC1.11e-143.38e-010.1323
11194ABCB8P5T-EHumanEsophagusESCC3.52e-193.43e-010.1327
11194ABCB8P8T-EHumanEsophagusESCC3.97e-041.13e-010.0889
11194ABCB8P9T-EHumanEsophagusESCC7.05e-122.64e-010.1131
11194ABCB8P10T-EHumanEsophagusESCC3.89e-121.97e-010.116
11194ABCB8P11T-EHumanEsophagusESCC7.14e-083.36e-010.1426
11194ABCB8P12T-EHumanEsophagusESCC1.77e-224.13e-010.1122
11194ABCB8P15T-EHumanEsophagusESCC9.59e-255.30e-010.1149
11194ABCB8P16T-EHumanEsophagusESCC1.18e-152.54e-010.1153
11194ABCB8P17T-EHumanEsophagusESCC5.85e-123.74e-010.1278
11194ABCB8P19T-EHumanEsophagusESCC1.11e-096.35e-010.1662
11194ABCB8P20T-EHumanEsophagusESCC4.83e-061.89e-010.1124
11194ABCB8P21T-EHumanEsophagusESCC2.49e-448.04e-010.1617
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa020102LiverHCCABC transporters29/402045/84651.62e-023.88e-022.16e-0229
hsa020103LiverHCCABC transporters29/402045/84651.62e-023.88e-022.16e-0229
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ABCB8SNVMissense_Mutationrs772895911c.1310G>Ap.Arg437Glnp.R437QQ9NUT2protein_codingdeleterious(0.02)probably_damaging(0.941)TCGA-A2-A0CO-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenCR
ABCB8SNVMissense_Mutationc.2064N>Tp.Trp688Cysp.W688CQ9NUT2protein_codingtolerated(0.27)benign(0)TCGA-A7-A13F-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydoxorubicinSD
ABCB8SNVMissense_Mutationrs374885136c.1100G>Ap.Arg367Glnp.R367QQ9NUT2protein_codingtolerated(0.14)benign(0)TCGA-AC-A5EH-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ABCB8SNVMissense_Mutationc.1735N>Ap.Glu579Lysp.E579KQ9NUT2protein_codingtolerated(0.14)benign(0.292)TCGA-AR-A24Q-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
ABCB8SNVMissense_Mutationc.748C>Ap.Gln250Lysp.Q250KQ9NUT2protein_codingtolerated(0.06)benign(0.115)TCGA-C8-A12T-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ABCB8SNVMissense_Mutationnovelc.19C>Gp.Arg7Glyp.R7GQ9NUT2protein_codingdeleterious_low_confidence(0)probably_damaging(0.995)TCGA-C8-A8HP-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapy5-fluorouracilCR
ABCB8SNVMissense_Mutationrs142475735c.997G>Ap.Val333Ilep.V333IQ9NUT2protein_codingtolerated(0.09)possibly_damaging(0.692)TCGA-D8-A1JT-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
ABCB8SNVMissense_Mutationc.867N>Tp.Met289Ilep.M289IQ9NUT2protein_codingtolerated(0.38)benign(0.003)TCGA-D8-A1XQ-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ABCB8SNVMissense_Mutationrs756291701c.298G>Ap.Val100Ilep.V100IQ9NUT2protein_codingtolerated_low_confidence(0.37)benign(0.001)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ABCB8SNVMissense_Mutationnovelc.1539N>Tp.Lys513Asnp.K513NQ9NUT2protein_codingdeleterious(0)probably_damaging(1)TCGA-5M-AAT6-01Colorectumcolon adenocarcinomaFemale<65III/IVUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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