Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: AARS2

Gene summary for AARS2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

AARS2

Gene ID

57505

Gene namealanyl-tRNA synthetase 2, mitochondrial
Gene AliasAARSL
Cytomap6p21.1
Gene Typeprotein-coding
GO ID

GO:0000959

UniProtAcc

Q5JTZ9


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
57505AARS2HCC1_MengHumanLiverHCC1.80e-058.28e-030.0246
57505AARS2HCC1HumanLiverHCC1.30e-132.01e+000.5336
57505AARS2HCC2HumanLiverHCC1.23e-272.56e+000.5341
57505AARS2HCC5HumanLiverHCC8.80e-221.94e+000.4932
57505AARS2S015HumanLiverHCC4.55e-042.61e-010.2375
57505AARS2S016HumanLiverHCC4.54e-051.91e-010.2243
57505AARS2S028HumanLiverHCC6.71e-031.51e-010.2503
Page: 1 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00344702LiverHCCncRNA processing293/7958395/187234.26e-386.76e-35293
GO:00346601LiverHCCncRNA metabolic process332/7958485/187231.48e-317.80e-29332
GO:01400531LiverHCCmitochondrial gene expression82/7958108/187231.49e-127.20e-1182
GO:00325431LiverHCCmitochondrial translation62/795876/187232.95e-121.34e-1062
GO:0008033LiverHCCtRNA processing87/7958127/187232.66e-097.23e-0887
GO:00065202LiverHCCcellular amino acid metabolic process167/7958284/187231.91e-084.56e-07167
GO:0006399LiverHCCtRNA metabolic process108/7958179/187231.07e-061.59e-05108
GO:0009451LiverHCCRNA modification101/7958167/187232.02e-062.78e-05101
GO:0006400LiverHCCtRNA modification60/795890/187233.09e-064.09e-0560
GO:0000959LiverHCCmitochondrial RNA metabolic process30/795849/187236.31e-032.57e-0230
Page: 1 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
AARS2SNVMissense_Mutationc.1135N>Cp.Val379Leup.V379LQ5JTZ9protein_codingdeleterious(0)probably_damaging(0.998)TCGA-A8-A09Q-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyanastrozoleSD
AARS2SNVMissense_Mutationrs756151860c.596N>Ap.Arg199Hisp.R199HQ5JTZ9protein_codingtolerated(0.79)benign(0.066)TCGA-AN-A0G0-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
AARS2SNVMissense_Mutationrs762132107c.1063C>Tp.Arg355Cysp.R355CQ5JTZ9protein_codingdeleterious(0)probably_damaging(1)TCGA-BH-A0BG-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
AARS2SNVMissense_Mutationnovelc.442N>Ap.Ala148Thrp.A148TQ5JTZ9protein_codingtolerated(0.06)possibly_damaging(0.905)TCGA-BH-A0HF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
AARS2SNVMissense_Mutationrs587777592c.1213N>Ap.Glu405Lysp.E405KQ5JTZ9protein_codingdeleterious(0)probably_damaging(0.999)TCGA-D8-A1XL-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicine+cyclophosphamide+tamoxifenSD
AARS2insertionNonsense_Mutationnovelc.2899_2900insTTTAAATTGGGCCCTGCTGGTTTGTTGATGAATTp.Thr967IlefsTer2p.T967Ifs*2Q5JTZ9protein_codingTCGA-B6-A0RE-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
AARS2deletionFrame_Shift_Delnovelc.1363_1381delNNNNNNNNNNNNNNNNNNNp.Leu455GlyfsTer4p.L455Gfs*4Q5JTZ9protein_codingTCGA-D8-A1JP-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
AARS2SNVMissense_Mutationnovelc.1126G>Ap.Val376Ilep.V376IQ5JTZ9protein_codingdeleterious(0.01)probably_damaging(0.998)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
AARS2SNVMissense_Mutationrs138828031c.2444N>Tp.Ala815Valp.A815VQ5JTZ9protein_codingtolerated(0.45)benign(0)TCGA-EA-A3HS-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
AARS2SNVMissense_Mutationc.2671N>Cp.Glu891Glnp.E891QQ5JTZ9protein_codingtolerated(0.35)benign(0.005)TCGA-UC-A7PG-06Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinPD
Page: 1 2 3 4 5 6 7 8 9 10 11 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1