Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: AARS1

Gene summary for AARS1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

AARS1

Gene ID

16

Gene namealanyl-tRNA synthetase 1
Gene AliasAARS
Cytomap16q22.1
Gene Typeprotein-coding
GO ID

GO:0002181

UniProtAcc

P49588


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
16AARS1HTA11_3410_2000001011HumanColorectumAD3.31e-071.59e-010.0155
16AARS1HTA11_2487_2000001011HumanColorectumSER5.80e-072.83e-01-0.1808
16AARS1HTA11_1938_2000001011HumanColorectumAD6.59e-072.09e-01-0.0811
16AARS1HTA11_78_2000001011HumanColorectumAD2.48e-072.49e-01-0.1088
16AARS1HTA11_347_2000001011HumanColorectumAD4.38e-152.91e-01-0.1954
16AARS1HTA11_411_2000001011HumanColorectumSER1.20e-075.05e-01-0.2602
16AARS1HTA11_3361_2000001011HumanColorectumAD1.34e-031.69e-01-0.1207
16AARS1HTA11_83_2000001011HumanColorectumSER2.16e-093.71e-01-0.1526
16AARS1HTA11_696_2000001011HumanColorectumAD2.10e-173.47e-01-0.1464
16AARS1HTA11_866_2000001011HumanColorectumAD5.56e-163.48e-01-0.1001
16AARS1HTA11_1391_2000001011HumanColorectumAD2.12e-215.09e-01-0.059
16AARS1HTA11_5216_2000001011HumanColorectumSER3.40e-021.93e-01-0.1462
16AARS1HTA11_546_2000001011HumanColorectumAD4.83e-082.75e-01-0.0842
16AARS1HTA11_9341_2000001011HumanColorectumSER5.61e-032.55e-01-0.00410000000000005
16AARS1HTA11_7862_2000001011HumanColorectumAD2.47e-083.22e-01-0.0179
16AARS1HTA11_866_3004761011HumanColorectumAD4.40e-163.70e-010.096
16AARS1HTA11_4255_2000001011HumanColorectumSER3.40e-032.22e-010.0446
16AARS1HTA11_9408_2000001011HumanColorectumAD9.81e-033.05e-010.0451
16AARS1HTA11_8622_2000001021HumanColorectumSER1.95e-073.65e-010.0528
16AARS1HTA11_7663_2000001011HumanColorectumSER6.81e-042.84e-010.0131
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0002181ColorectumADcytoplasmic translation109/3918148/187233.40e-432.13e-39109
GO:0070997ColorectumADneuron death114/3918361/187231.13e-063.72e-05114
GO:0006417ColorectumADregulation of translation141/3918468/187231.32e-064.22e-05141
GO:1901214ColorectumADregulation of neuron death99/3918319/187231.26e-052.76e-0499
GO:0051402ColorectumADneuron apoptotic process77/3918246/187238.07e-051.28e-0377
GO:1901215ColorectumADnegative regulation of neuron death67/3918208/187238.81e-051.35e-0367
GO:0006418ColorectumADtRNA aminoacylation for protein translation19/391841/187232.37e-043.03e-0319
GO:0043039ColorectumADtRNA aminoacylation19/391844/187237.13e-047.21e-0319
GO:0043523ColorectumADregulation of neuron apoptotic process64/3918212/187238.95e-048.63e-0364
GO:0043038ColorectumADamino acid activation19/391845/187239.94e-049.28e-0319
GO:0006520ColorectumADcellular amino acid metabolic process81/3918284/187231.37e-031.19e-0281
GO:0006414ColorectumADtranslational elongation21/391855/187232.53e-031.93e-0221
GO:0043524ColorectumADnegative regulation of neuron apoptotic process43/3918145/187238.04e-034.73e-0243
GO:00021811ColorectumSERcytoplasmic translation102/2897148/187231.38e-488.49e-45102
GO:00064181ColorectumSERtRNA aminoacylation for protein translation17/289741/187235.75e-051.35e-0317
GO:00709971ColorectumSERneuron death84/2897361/187235.76e-051.35e-0384
GO:00430391ColorectumSERtRNA aminoacylation17/289744/187231.64e-043.12e-0317
GO:00514021ColorectumSERneuron apoptotic process60/2897246/187231.65e-043.13e-0360
GO:00430381ColorectumSERamino acid activation17/289745/187232.25e-043.91e-0317
GO:00064171ColorectumSERregulation of translation100/2897468/187233.76e-045.74e-03100
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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