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Gene: AAED1 |
Gene summary for AAED1 |
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Gene information | Species | Human | Gene symbol | AAED1 | Gene ID | 195827 |
Gene name | peroxiredoxin like 2C | |
Gene Alias | AAED1 | |
Cytomap | 9q22.33 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q7RTV5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
195827 | AAED1 | P2T-E | Human | Esophagus | ESCC | 6.79e-21 | 3.66e-01 | 0.1177 |
195827 | AAED1 | P4T-E | Human | Esophagus | ESCC | 9.76e-15 | 4.53e-01 | 0.1323 |
195827 | AAED1 | P5T-E | Human | Esophagus | ESCC | 2.54e-14 | 1.65e-01 | 0.1327 |
195827 | AAED1 | P8T-E | Human | Esophagus | ESCC | 4.96e-14 | 9.81e-02 | 0.0889 |
195827 | AAED1 | P9T-E | Human | Esophagus | ESCC | 1.75e-14 | 4.04e-01 | 0.1131 |
195827 | AAED1 | P10T-E | Human | Esophagus | ESCC | 2.07e-16 | 8.15e-02 | 0.116 |
195827 | AAED1 | P11T-E | Human | Esophagus | ESCC | 2.86e-10 | 6.81e-01 | 0.1426 |
195827 | AAED1 | P12T-E | Human | Esophagus | ESCC | 2.05e-20 | 2.98e-01 | 0.1122 |
195827 | AAED1 | P15T-E | Human | Esophagus | ESCC | 4.29e-09 | 1.88e-01 | 0.1149 |
195827 | AAED1 | P16T-E | Human | Esophagus | ESCC | 2.88e-18 | 8.22e-02 | 0.1153 |
195827 | AAED1 | P17T-E | Human | Esophagus | ESCC | 1.96e-03 | 4.64e-01 | 0.1278 |
195827 | AAED1 | P19T-E | Human | Esophagus | ESCC | 3.30e-04 | 6.25e-01 | 0.1662 |
195827 | AAED1 | P20T-E | Human | Esophagus | ESCC | 9.29e-12 | 3.57e-01 | 0.1124 |
195827 | AAED1 | P21T-E | Human | Esophagus | ESCC | 6.89e-47 | 1.02e+00 | 0.1617 |
195827 | AAED1 | P22T-E | Human | Esophagus | ESCC | 3.13e-05 | 1.26e-01 | 0.1236 |
195827 | AAED1 | P23T-E | Human | Esophagus | ESCC | 2.69e-07 | 2.66e-01 | 0.108 |
195827 | AAED1 | P24T-E | Human | Esophagus | ESCC | 4.66e-20 | 4.54e-01 | 0.1287 |
195827 | AAED1 | P26T-E | Human | Esophagus | ESCC | 5.28e-17 | 9.24e-02 | 0.1276 |
195827 | AAED1 | P27T-E | Human | Esophagus | ESCC | 1.15e-11 | 1.21e-01 | 0.1055 |
195827 | AAED1 | P28T-E | Human | Esophagus | ESCC | 3.33e-16 | 3.18e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AAED1 | SNV | Missense_Mutation | c.614N>A | p.Ser205Tyr | p.S205Y | Q7RTV5 | protein_coding | tolerated(0.36) | benign(0.298) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AAED1 | SNV | Missense_Mutation | c.662C>A | p.Pro221His | p.P221H | Q7RTV5 | protein_coding | deleterious(0.04) | possibly_damaging(0.885) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
AAED1 | SNV | Missense_Mutation | c.228N>T | p.Glu76Asp | p.E76D | Q7RTV5 | protein_coding | tolerated(0.15) | benign(0.078) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
AAED1 | SNV | Missense_Mutation | novel | c.370N>A | p.Glu124Lys | p.E124K | Q7RTV5 | protein_coding | tolerated(0.52) | benign(0.009) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AAED1 | SNV | Missense_Mutation | novel | c.252N>G | p.Ser84Arg | p.S84R | Q7RTV5 | protein_coding | tolerated(0.31) | benign(0.079) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AAED1 | SNV | Missense_Mutation | novel | c.448N>A | p.Leu150Ile | p.L150I | Q7RTV5 | protein_coding | tolerated(0.54) | benign(0.003) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AAED1 | SNV | Missense_Mutation | novel | c.455N>T | p.Ser152Leu | p.S152L | Q7RTV5 | protein_coding | tolerated(0.43) | benign(0.015) | TCGA-55-6968-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | unknown | PD |
AAED1 | SNV | Missense_Mutation | c.431C>T | p.Pro144Leu | p.P144L | Q7RTV5 | protein_coding | deleterious(0.03) | probably_damaging(0.98) | TCGA-55-A491-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AAED1 | SNV | Missense_Mutation | c.641N>G | p.His214Arg | p.H214R | Q7RTV5 | protein_coding | tolerated(0.41) | benign(0.005) | TCGA-EJ-7330-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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