GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004325427 | Esophagus | HGIN | regulation of protein-containing complex assembly | 94/2587 | 428/18723 | 2.39e-06 | 8.55e-05 | 94 |
GO:007149626 | Esophagus | HGIN | cellular response to external stimulus | 71/2587 | 320/18723 | 2.77e-05 | 7.19e-04 | 71 |
GO:190165420 | Esophagus | HGIN | response to ketone | 48/2587 | 194/18723 | 3.17e-05 | 8.12e-04 | 48 |
GO:190290327 | Esophagus | HGIN | regulation of supramolecular fiber organization | 79/2587 | 383/18723 | 1.40e-04 | 2.81e-03 | 79 |
GO:009730520 | Esophagus | HGIN | response to alcohol | 54/2587 | 253/18723 | 6.46e-04 | 8.87e-03 | 54 |
GO:003297027 | Esophagus | HGIN | regulation of actin filament-based process | 77/2587 | 397/18723 | 1.14e-03 | 1.39e-02 | 77 |
GO:007121418 | Esophagus | HGIN | cellular response to abiotic stimulus | 66/2587 | 331/18723 | 1.21e-03 | 1.45e-02 | 66 |
GO:010400418 | Esophagus | HGIN | cellular response to environmental stimulus | 66/2587 | 331/18723 | 1.21e-03 | 1.45e-02 | 66 |
GO:003295627 | Esophagus | HGIN | regulation of actin cytoskeleton organization | 69/2587 | 358/18723 | 2.35e-03 | 2.39e-02 | 69 |
GO:003133320 | Esophagus | HGIN | negative regulation of protein-containing complex assembly | 32/2587 | 141/18723 | 2.80e-03 | 2.74e-02 | 32 |
GO:000150316 | Esophagus | HGIN | ossification | 75/2587 | 408/18723 | 5.49e-03 | 4.49e-02 | 75 |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:0071496111 | Esophagus | ESCC | cellular response to external stimulus | 215/8552 | 320/18723 | 4.29e-15 | 2.43e-13 | 215 |
GO:1902903111 | Esophagus | ESCC | regulation of supramolecular fiber organization | 237/8552 | 383/18723 | 9.06e-11 | 2.75e-09 | 237 |
GO:007121419 | Esophagus | ESCC | cellular response to abiotic stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:010400419 | Esophagus | ESCC | cellular response to environmental stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:003109818 | Esophagus | ESCC | stress-activated protein kinase signaling cascade | 154/8552 | 247/18723 | 8.53e-08 | 1.44e-06 | 154 |
GO:0032970111 | Esophagus | ESCC | regulation of actin filament-based process | 231/8552 | 397/18723 | 2.91e-07 | 4.20e-06 | 231 |
GO:0032956111 | Esophagus | ESCC | regulation of actin cytoskeleton organization | 210/8552 | 358/18723 | 4.40e-07 | 6.00e-06 | 210 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTGER4 | SNV | Missense_Mutation | novel | c.157N>T | p.Thr53Ser | p.T53S | P35408 | protein_coding | deleterious(0.01) | possibly_damaging(0.72) | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PTGER4 | SNV | Missense_Mutation | rs755244149 | c.1073N>A | p.Arg358His | p.R358H | P35408 | protein_coding | tolerated(0.33) | benign(0) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR |
PTGER4 | SNV | Missense_Mutation | novel | c.1093N>T | p.Asp365Tyr | p.D365Y | P35408 | protein_coding | deleterious(0) | benign(0.112) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
PTGER4 | insertion | Nonsense_Mutation | novel | c.155_156insAGTTTATAAATATTAAT | p.Thr53ValfsTer5 | p.T53Vfs*5 | P35408 | protein_coding | | | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PTGER4 | SNV | Missense_Mutation | novel | c.1349G>A | p.Ser450Asn | p.S450N | P35408 | protein_coding | tolerated_low_confidence(0.32) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PTGER4 | SNV | Missense_Mutation | | c.956N>T | p.Ser319Phe | p.S319F | P35408 | protein_coding | deleterious(0) | benign(0.209) | TCGA-C5-A7CO-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
PTGER4 | SNV | Missense_Mutation | rs371545658 | c.23N>T | p.Ser8Leu | p.S8L | P35408 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PTGER4 | SNV | Missense_Mutation | | c.1010N>G | p.Leu337Arg | p.L337R | P35408 | protein_coding | deleterious(0) | benign(0.052) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTGER4 | SNV | Missense_Mutation | | c.947N>A | p.Arg316Gln | p.R316Q | P35408 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PTGER4 | SNV | Missense_Mutation | novel | c.317N>A | p.Gly106Asp | p.G106D | P35408 | protein_coding | deleterious(0.01) | probably_damaging(0.933) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5734 | PTGER4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE | agonist | 135651538 | | |
5734 | PTGER4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE | | AC-100,DENTONIN | | |
5734 | PTGER4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE | | BGC-20-1531 | | 19154437 |
5734 | PTGER4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE | | PGF2alpha | | |
5734 | PTGER4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE | agonist | 178100863 | | |
5734 | PTGER4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE | | celecoxib | CELECOXIB | 23778325 |
5734 | PTGER4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE | antagonist | 135650770 | | |
5734 | PTGER4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, KINASE | agonist | 135651374 | | |