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Gene: HRH4 |
Gene summary for HRH4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | HRH4 | Gene ID | 59340 |
Gene name | histamine receptor H4 | |
Gene Alias | AXOR35 | |
Cytomap | 18q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9H3N8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
59340 | HRH4 | HCC1 | Human | Liver | HCC | 1.73e-10 | 1.68e+00 | 0.5336 |
59340 | HRH4 | HCC2 | Human | Liver | HCC | 9.31e-26 | 1.40e+00 | 0.5341 |
59340 | HRH4 | HCC5 | Human | Liver | HCC | 1.48e-15 | 1.26e+00 | 0.4932 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HRH4 | SNV | Missense_Mutation | novel | c.1133N>G | p.Gln378Arg | p.Q378R | Q9H3N8 | protein_coding | tolerated(0.14) | benign(0.115) | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HRH4 | SNV | Missense_Mutation | c.452N>C | p.Ile151Thr | p.I151T | Q9H3N8 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |
HRH4 | SNV | Missense_Mutation | c.992C>T | p.Ser331Leu | p.S331L | Q9H3N8 | protein_coding | tolerated(0.23) | benign(0.02) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
HRH4 | SNV | Missense_Mutation | c.989C>T | p.Ser330Phe | p.S330F | Q9H3N8 | protein_coding | tolerated(0.7) | possibly_damaging(0.625) | TCGA-E9-A243-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | |
HRH4 | insertion | Nonsense_Mutation | novel | c.1135_1136insTAAGATGA | p.Pro379LeufsTer3 | p.P379Lfs*3 | Q9H3N8 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HRH4 | SNV | Missense_Mutation | rs747220498 | c.235N>A | p.Glu79Lys | p.E79K | Q9H3N8 | protein_coding | tolerated(1) | benign(0.01) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HRH4 | SNV | Missense_Mutation | c.43N>T | p.Arg15Cys | p.R15C | Q9H3N8 | protein_coding | tolerated(0.14) | benign(0) | TCGA-EK-A2GZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
HRH4 | SNV | Missense_Mutation | c.368G>T | p.Arg123Ile | p.R123I | Q9H3N8 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HRH4 | SNV | Missense_Mutation | rs773632780 | c.571N>A | p.Ala191Thr | p.A191T | Q9H3N8 | protein_coding | tolerated(0.93) | benign(0.136) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HRH4 | SNV | Missense_Mutation | c.1151N>G | p.His384Arg | p.H384R | Q9H3N8 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
59340 | HRH4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | REV131 | |||
59340 | HRH4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | VUF-10499 | CHEMBL454890 | 19053770 | |
59340 | HRH4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | JNJ-38518168 | TOREFORANT | 25873897 | |
59340 | HRH4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 135651168 | ||
59340 | HRH4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650381 | IMETIT | |
59340 | HRH4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 310264762 | ||
59340 | HRH4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | UR-63325 | UR-63325 | ||
59340 | HRH4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 135650115 | CLOZAPINE | |
59340 | HRH4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | THIOPERAMIDE | THIOPERAMIDE | 19053770,20192225 | |
59340 | HRH4 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135652494 |
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