GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009636 | Colorectum | AD | response to toxic substance | 88/3918 | 262/18723 | 1.12e-06 | 3.72e-05 | 88 |
GO:0098754 | Colorectum | AD | detoxification | 53/3918 | 152/18723 | 4.63e-05 | 7.98e-04 | 53 |
GO:0009410 | Colorectum | AD | response to xenobiotic stimulus | 128/3918 | 462/18723 | 2.69e-04 | 3.31e-03 | 128 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:0032411 | Colorectum | AD | positive regulation of transporter activity | 37/3918 | 120/18723 | 6.82e-03 | 4.22e-02 | 37 |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:00096362 | Colorectum | MSS | response to toxic substance | 73/3467 | 262/18723 | 1.26e-04 | 1.94e-03 | 73 |
GO:0150104 | Colorectum | MSS | transport across blood-brain barrier | 28/3467 | 87/18723 | 1.54e-03 | 1.41e-02 | 28 |
GO:0010232 | Colorectum | MSS | vascular transport | 28/3467 | 88/18723 | 1.87e-03 | 1.64e-02 | 28 |
GO:00324091 | Colorectum | MSS | regulation of transporter activity | 78/3467 | 310/18723 | 2.09e-03 | 1.78e-02 | 78 |
GO:0070633 | Colorectum | MSS | transepithelial transport | 13/3467 | 31/18723 | 2.14e-03 | 1.80e-02 | 13 |
GO:00428861 | Colorectum | MSS | amide transport | 76/3467 | 301/18723 | 2.14e-03 | 1.80e-02 | 76 |
GO:0034764 | Colorectum | MSS | positive regulation of transmembrane transport | 58/3467 | 219/18723 | 2.19e-03 | 1.83e-02 | 58 |
GO:00094101 | Colorectum | MSS | response to xenobiotic stimulus | 110/3467 | 462/18723 | 2.36e-03 | 1.92e-02 | 110 |
GO:00324112 | Colorectum | MSS | positive regulation of transporter activity | 35/3467 | 120/18723 | 2.95e-03 | 2.28e-02 | 35 |
GO:0022898 | Colorectum | MSS | regulation of transmembrane transporter activity | 70/3467 | 278/18723 | 3.36e-03 | 2.54e-02 | 70 |
GO:00987542 | Colorectum | MSS | detoxification | 41/3467 | 152/18723 | 6.41e-03 | 4.27e-02 | 41 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABCB1 | SNV | Missense_Mutation | | c.2966N>A | p.Gly989Glu | p.G989E | P08183 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A04U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ABCB1 | SNV | Missense_Mutation | rs776877163 | c.3194C>T | p.Thr1065Met | p.T1065M | P08183 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABCB1 | SNV | Missense_Mutation | rs36105130 | c.2547N>G | p.Ile849Met | p.I849M | P08183 | protein_coding | deleterious(0.04) | possibly_damaging(0.626) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABCB1 | SNV | Missense_Mutation | rs201352027 | c.1211N>A | p.Arg404Gln | p.R404Q | P08183 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AQ-A54N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABCB1 | SNV | Missense_Mutation | | c.2320N>A | p.Gly774Ser | p.G774S | P08183 | protein_coding | tolerated(0.08) | probably_damaging(0.927) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
ABCB1 | SNV | Missense_Mutation | | c.1561N>C | p.Asp521His | p.D521H | P08183 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABCB1 | SNV | Missense_Mutation | | c.2816N>C | p.Gly939Ala | p.G939A | P08183 | protein_coding | deleterious(0.03) | probably_damaging(0.981) | TCGA-BH-A1F0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ABCB1 | SNV | Missense_Mutation | rs139611979 | c.1342N>A | p.Glu448Lys | p.E448K | P08183 | protein_coding | tolerated(0.12) | possibly_damaging(0.61) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
ABCB1 | SNV | Missense_Mutation | novel | c.170N>G | p.Ala57Gly | p.A57G | P08183 | protein_coding | tolerated(0.24) | benign(0.269) | TCGA-EW-A1PC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
ABCB1 | deletion | Frame_Shift_Del | novel | c.568delN | p.Ile190LeufsTer16 | p.I190Lfs*16 | P08183 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5243 | ABCB1 | CLINICALLY ACTIONABLE, TRANSPORTER, DRUGGABLE GENOME, ENZYME, CELL SURFACE, DRUG RESISTANCE, ABC TRANSPORTER | | DAUNORUBICIN | DAUNORUBICIN | 10500777 |
5243 | ABCB1 | CLINICALLY ACTIONABLE, TRANSPORTER, DRUGGABLE GENOME, ENZYME, CELL SURFACE, DRUG RESISTANCE, ABC TRANSPORTER | | warfarin | WARFARIN | 25312789,29875668,22248286,29432897 |
5243 | ABCB1 | CLINICALLY ACTIONABLE, TRANSPORTER, DRUGGABLE GENOME, ENZYME, CELL SURFACE, DRUG RESISTANCE, ABC TRANSPORTER | | CODEINE | CODEINE | 18311899 |
5243 | ABCB1 | CLINICALLY ACTIONABLE, TRANSPORTER, DRUGGABLE GENOME, ENZYME, CELL SURFACE, DRUG RESISTANCE, ABC TRANSPORTER | | vecuronium | VECURONIUM | |
5243 | ABCB1 | CLINICALLY ACTIONABLE, TRANSPORTER, DRUGGABLE GENOME, ENZYME, CELL SURFACE, DRUG RESISTANCE, ABC TRANSPORTER | | lenalidomide | LENALIDOMIDE | 29177954 |
5243 | ABCB1 | CLINICALLY ACTIONABLE, TRANSPORTER, DRUGGABLE GENOME, ENZYME, CELL SURFACE, DRUG RESISTANCE, ABC TRANSPORTER | | astemizole | ASTEMIZOLE | |
5243 | ABCB1 | CLINICALLY ACTIONABLE, TRANSPORTER, DRUGGABLE GENOME, ENZYME, CELL SURFACE, DRUG RESISTANCE, ABC TRANSPORTER | | EDP-322 | | |
5243 | ABCB1 | CLINICALLY ACTIONABLE, TRANSPORTER, DRUGGABLE GENOME, ENZYME, CELL SURFACE, DRUG RESISTANCE, ABC TRANSPORTER | | ritonavir | RITONAVIR | 17324111,26174719,14600574,24997317,16355344,23996099,28718515,1655344,21288825,25151207,20504240,25622064,17148966,26857335 |
5243 | ABCB1 | CLINICALLY ACTIONABLE, TRANSPORTER, DRUGGABLE GENOME, ENZYME, CELL SURFACE, DRUG RESISTANCE, ABC TRANSPORTER | | sirolimus | SIROLIMUS | 23073467,28676933 |
5243 | ABCB1 | CLINICALLY ACTIONABLE, TRANSPORTER, DRUGGABLE GENOME, ENZYME, CELL SURFACE, DRUG RESISTANCE, ABC TRANSPORTER | | antipsychotics | | 22909202 |