![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SNCA |
Gene summary for SNCA |
![]() |
Gene information | Species | Human | Gene symbol | SNCA | Gene ID | 6622 |
Gene name | synuclein alpha | |
Gene Alias | NACP | |
Cytomap | 4q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P37840 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6622 | SNCA | P2T-E | Human | Esophagus | ESCC | 1.48e-16 | 3.68e-01 | 0.1177 |
6622 | SNCA | P8T-E | Human | Esophagus | ESCC | 2.40e-13 | 4.25e-01 | 0.0889 |
6622 | SNCA | P9T-E | Human | Esophagus | ESCC | 2.04e-04 | 2.64e-01 | 0.1131 |
6622 | SNCA | P10T-E | Human | Esophagus | ESCC | 7.30e-42 | 7.83e-01 | 0.116 |
6622 | SNCA | P11T-E | Human | Esophagus | ESCC | 1.77e-09 | 7.33e-01 | 0.1426 |
6622 | SNCA | P12T-E | Human | Esophagus | ESCC | 9.01e-04 | 1.91e-01 | 0.1122 |
6622 | SNCA | P15T-E | Human | Esophagus | ESCC | 1.09e-28 | 7.95e-01 | 0.1149 |
6622 | SNCA | P16T-E | Human | Esophagus | ESCC | 9.44e-10 | 2.42e-01 | 0.1153 |
6622 | SNCA | P21T-E | Human | Esophagus | ESCC | 2.61e-10 | 4.90e-01 | 0.1617 |
6622 | SNCA | P24T-E | Human | Esophagus | ESCC | 4.21e-04 | 4.65e-02 | 0.1287 |
6622 | SNCA | P26T-E | Human | Esophagus | ESCC | 8.01e-13 | 4.86e-01 | 0.1276 |
6622 | SNCA | P28T-E | Human | Esophagus | ESCC | 4.97e-05 | 3.39e-01 | 0.1149 |
6622 | SNCA | P30T-E | Human | Esophagus | ESCC | 1.14e-08 | 7.63e-01 | 0.137 |
6622 | SNCA | P32T-E | Human | Esophagus | ESCC | 3.36e-22 | 7.82e-01 | 0.1666 |
6622 | SNCA | P36T-E | Human | Esophagus | ESCC | 2.79e-02 | 6.05e-01 | 0.1187 |
6622 | SNCA | P37T-E | Human | Esophagus | ESCC | 1.38e-09 | 2.63e-01 | 0.1371 |
6622 | SNCA | P40T-E | Human | Esophagus | ESCC | 3.86e-03 | 3.17e-01 | 0.109 |
6622 | SNCA | P49T-E | Human | Esophagus | ESCC | 3.88e-05 | 1.20e+00 | 0.1768 |
6622 | SNCA | P52T-E | Human | Esophagus | ESCC | 2.88e-06 | 5.58e-01 | 0.1555 |
6622 | SNCA | P57T-E | Human | Esophagus | ESCC | 1.05e-09 | 5.16e-01 | 0.0926 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:0045333110 | Esophagus | ESCC | cellular respiration | 173/8552 | 230/18723 | 4.53e-20 | 5.99e-18 | 173 |
GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:0009060110 | Esophagus | ESCC | aerobic respiration | 145/8552 | 189/18723 | 2.16e-18 | 2.21e-16 | 145 |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:001050617 | Esophagus | ESCC | regulation of autophagy | 220/8552 | 317/18723 | 6.72e-18 | 6.36e-16 | 220 |
GO:0015980110 | Esophagus | ESCC | energy derivation by oxidation of organic compounds | 220/8552 | 318/18723 | 1.20e-17 | 1.09e-15 | 220 |
GO:0022900110 | Esophagus | ESCC | electron transport chain | 133/8552 | 175/18723 | 2.18e-16 | 1.67e-14 | 133 |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:0046034111 | Esophagus | ESCC | ATP metabolic process | 189/8552 | 277/18723 | 1.99e-14 | 1.04e-12 | 189 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501038 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0501230 | Oral cavity | OSCC | Parkinson disease | 188/3704 | 266/8465 | 1.82e-19 | 1.52e-17 | 7.75e-18 | 188 |
hsa0501028 | Oral cavity | OSCC | Alzheimer disease | 244/3704 | 384/8465 | 1.18e-15 | 3.60e-14 | 1.83e-14 | 244 |
hsa0502228 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa05012113 | Oral cavity | OSCC | Parkinson disease | 188/3704 | 266/8465 | 1.82e-19 | 1.52e-17 | 7.75e-18 | 188 |
hsa05010112 | Oral cavity | OSCC | Alzheimer disease | 244/3704 | 384/8465 | 1.18e-15 | 3.60e-14 | 1.83e-14 | 244 |
hsa05022112 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa05012210 | Oral cavity | LP | Parkinson disease | 166/2418 | 266/8465 | 2.02e-31 | 3.36e-29 | 2.17e-29 | 166 |
hsa0501029 | Oral cavity | LP | Alzheimer disease | 197/2418 | 384/8465 | 6.66e-22 | 3.69e-20 | 2.38e-20 | 197 |
hsa0502229 | Oral cavity | LP | Pathways of neurodegeneration - multiple diseases | 232/2418 | 476/8465 | 7.77e-22 | 3.69e-20 | 2.38e-20 | 232 |
hsa0501238 | Oral cavity | LP | Parkinson disease | 166/2418 | 266/8465 | 2.02e-31 | 3.36e-29 | 2.17e-29 | 166 |
hsa0501037 | Oral cavity | LP | Alzheimer disease | 197/2418 | 384/8465 | 6.66e-22 | 3.69e-20 | 2.38e-20 | 197 |
hsa0502237 | Oral cavity | LP | Pathways of neurodegeneration - multiple diseases | 232/2418 | 476/8465 | 7.77e-22 | 3.69e-20 | 2.38e-20 | 232 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNCA | SNV | Missense_Mutation | c.152N>T | p.Gly51Val | p.G51V | P37840 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SNCA | SNV | Missense_Mutation | novel | c.249N>T | p.Glu83Asp | p.E83D | P37840 | protein_coding | deleterious(0.03) | probably_damaging(0.927) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SNCA | SNV | Missense_Mutation | rs548523899 | c.287N>G | p.Lys96Arg | p.K96R | P37840 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
SNCA | SNV | Missense_Mutation | novel | c.176N>T | p.Thr59Ile | p.T59I | P37840 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SNCA | SNV | Missense_Mutation | novel | c.403G>T | p.Asp135Tyr | p.D135Y | P37840 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.455) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SNCA | SNV | Missense_Mutation | c.386N>T | p.Ser129Phe | p.S129F | P37840 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.586) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
SNCA | SNV | Missense_Mutation | c.4N>T | p.Asp2Tyr | p.D2Y | P37840 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
SNCA | SNV | Missense_Mutation | c.290N>T | p.Lys97Met | p.K97M | P37840 | protein_coding | deleterious(0.04) | probably_damaging(0.927) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SNCA | SNV | Missense_Mutation | novel | c.409N>A | p.Glu137Lys | p.E137K | P37840 | protein_coding | deleterious_low_confidence(0.01) | benign(0.025) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SNCA | SNV | Missense_Mutation | c.41N>A | p.Gly14Glu | p.G14E | P37840 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DD-A4NF-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6622 | SNCA | DRUGGABLE GENOME, TRANSPORTER | LICARIN A | LICARIN A | ||
6622 | SNCA | DRUGGABLE GENOME, TRANSPORTER | TDR77403 | CHEMBL1534035 | ||
6622 | SNCA | DRUGGABLE GENOME, TRANSPORTER | MMV666022 | CHEMBL599100 | ||
6622 | SNCA | DRUGGABLE GENOME, TRANSPORTER | DNDI1417254 | CHEMBL2094567 | ||
6622 | SNCA | DRUGGABLE GENOME, TRANSPORTER | ABT-702 | CHEMBL66089 | ||
6622 | SNCA | DRUGGABLE GENOME, TRANSPORTER | CAFFEIC ACID PHENETHYL ESTER | CAFFEIC ACID PHENETHYL ESTER | ||
6622 | SNCA | DRUGGABLE GENOME, TRANSPORTER | inhibitor | CHEMBL3833330 | CINPANEMAB | |
6622 | SNCA | DRUGGABLE GENOME, TRANSPORTER | 4-(4-CHLOROPHENOXY)ANILINE | CHEMBL1521156 | ||
6622 | SNCA | DRUGGABLE GENOME, TRANSPORTER | N-(3-CARBOXYPHENYL)RHODANINE | CHEMBL442906 | ||
6622 | SNCA | DRUGGABLE GENOME, TRANSPORTER | GENTIAN VIOLET | GENTIAN VIOLET |
Page: 1 2 3 4 |