GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:0042326111 | Esophagus | ESCC | negative regulation of phosphorylation | 237/8552 | 385/18723 | 1.86e-10 | 5.33e-09 | 237 |
GO:0001933111 | Esophagus | ESCC | negative regulation of protein phosphorylation | 213/8552 | 342/18723 | 3.54e-10 | 9.76e-09 | 213 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:0051235110 | Esophagus | ESCC | maintenance of location | 200/8552 | 327/18723 | 1.01e-08 | 2.02e-07 | 200 |
GO:00459267 | Esophagus | ESCC | negative regulation of growth | 148/8552 | 249/18723 | 7.88e-06 | 7.73e-05 | 148 |
GO:0051651111 | Esophagus | ESCC | maintenance of location in cell | 126/8552 | 214/18723 | 6.57e-05 | 5.00e-04 | 126 |
GO:003249619 | Esophagus | ESCC | response to lipopolysaccharide | 191/8552 | 343/18723 | 1.11e-04 | 7.73e-04 | 191 |
GO:000961216 | Esophagus | ESCC | response to mechanical stimulus | 124/8552 | 216/18723 | 3.30e-04 | 1.94e-03 | 124 |
GO:00303085 | Esophagus | ESCC | negative regulation of cell growth | 108/8552 | 188/18723 | 7.46e-04 | 3.87e-03 | 108 |
GO:000223719 | Esophagus | ESCC | response to molecule of bacterial origin | 194/8552 | 363/18723 | 1.64e-03 | 7.61e-03 | 194 |
GO:000268515 | Esophagus | ESCC | regulation of leukocyte migration | 114/8552 | 210/18723 | 7.26e-03 | 2.63e-02 | 114 |
GO:001604917 | Oral cavity | OSCC | cell growth | 268/7305 | 482/18723 | 6.55e-14 | 3.51e-12 | 268 |
GO:001056320 | Oral cavity | OSCC | negative regulation of phosphorus metabolic process | 246/7305 | 442/18723 | 6.12e-13 | 2.89e-11 | 246 |
GO:004593620 | Oral cavity | OSCC | negative regulation of phosphate metabolic process | 245/7305 | 441/18723 | 8.85e-13 | 4.09e-11 | 245 |
GO:000155816 | Oral cavity | OSCC | regulation of cell growth | 228/7305 | 414/18723 | 1.74e-11 | 6.09e-10 | 228 |
GO:004232619 | Oral cavity | OSCC | negative regulation of phosphorylation | 214/7305 | 385/18723 | 2.30e-11 | 7.74e-10 | 214 |
GO:000193319 | Oral cavity | OSCC | negative regulation of protein phosphorylation | 191/7305 | 342/18723 | 1.58e-10 | 4.62e-09 | 191 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BDKRB1 | SNV | Missense_Mutation | rs747328339 | c.689N>A | p.Arg230Gln | p.R230Q | P46663 | protein_coding | tolerated(0.15) | possibly_damaging(0.595) | TCGA-A2-A04U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
BDKRB1 | SNV | Missense_Mutation | | c.315N>G | p.Phe105Leu | p.F105L | P46663 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BDKRB1 | SNV | Missense_Mutation | | c.8C>T | p.Ser3Leu | p.S3L | P46663 | protein_coding | deleterious_low_confidence(0.03) | benign(0) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BDKRB1 | SNV | Missense_Mutation | novel | c.1025A>G | p.His342Arg | p.H342R | P46663 | protein_coding | tolerated(0.71) | benign(0) | TCGA-E2-A2P5-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | PD |
BDKRB1 | SNV | Missense_Mutation | novel | c.617N>C | p.Leu206Ser | p.L206S | P46663 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-GM-A2DN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
BDKRB1 | SNV | Missense_Mutation | rs371690606 | c.694N>T | p.Arg232Trp | p.R232W | P46663 | protein_coding | deleterious(0.04) | probably_damaging(0.987) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BDKRB1 | SNV | Missense_Mutation | rs780064132 | c.167N>C | p.Leu56Pro | p.L56P | P46663 | protein_coding | deleterious(0.01) | possibly_damaging(0.878) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BDKRB1 | SNV | Missense_Mutation | novel | c.1021N>A | p.Ser341Thr | p.S341T | P46663 | protein_coding | tolerated(0.31) | benign(0.2) | TCGA-MA-AA43-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
BDKRB1 | SNV | Missense_Mutation | novel | c.893N>C | p.Asn298Thr | p.N298T | P46663 | protein_coding | tolerated(0.6) | benign(0.007) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
BDKRB1 | SNV | Missense_Mutation | novel | c.1002N>G | p.Ser334Arg | p.S334R | P46663 | protein_coding | tolerated(0.34) | benign(0) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
623 | BDKRB1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135652115 | | |
623 | BDKRB1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 135650862 | | |
623 | BDKRB1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 135651088 | | |
623 | BDKRB1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 135652267 | | |
623 | BDKRB1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 135652196 | ICATIBANT | |
623 | BDKRB1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | | SSR-240612 | | 17618300 |
623 | BDKRB1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | CHEMBL232943 | MK0686 | |
623 | BDKRB1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135652286 | | |
623 | BDKRB1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | | BI 113823 | | |
623 | BDKRB1 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135652110 | | |