Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: OPRK1

Gene summary for OPRK1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

OPRK1

Gene ID

4986

Gene nameopioid receptor kappa 1
Gene AliasK-OR-1
Cytomap8q11.23
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

P41145


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
4986OPRK1S014HumanLiverHCC3.20e-268.87e-010.2254
4986OPRK1S015HumanLiverHCC1.42e-093.49e-010.2375
4986OPRK1S016HumanLiverHCC2.44e-349.97e-010.2243
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:003286821LiverHCCresponse to insulin172/7958264/187237.14e-144.23e-12172
GO:004343422LiverHCCresponse to peptide hormone247/7958414/187239.55e-134.77e-11247
GO:000961511LiverHCCresponse to virus210/7958367/187237.32e-091.86e-07210
GO:000974322LiverHCCresponse to carbohydrate149/7958253/187239.55e-081.89e-06149
GO:00516071LiverHCCdefense response to virus151/7958265/187231.27e-061.85e-05151
GO:01405461LiverHCCdefense response to symbiont151/7958265/187231.27e-061.85e-05151
GO:003428422LiverHCCresponse to monosaccharide131/7958225/187231.32e-061.91e-05131
GO:000974622LiverHCCresponse to hexose126/7958219/187234.81e-066.06e-05126
GO:000974912LiverHCCresponse to glucose121/7958212/187231.24e-051.39e-04121
GO:003109822LiverHCCstress-activated protein kinase signaling cascade138/7958247/187231.43e-051.57e-04138
GO:005140322LiverHCCstress-activated MAPK cascade134/7958239/187231.50e-051.64e-04134
GO:009730522LiverHCCresponse to alcohol138/7958253/187236.91e-056.26e-04138
GO:004851121LiverHCCrhythmic process156/7958298/187233.54e-042.46e-03156
GO:004259322LiverHCCglucose homeostasis137/7958258/187233.59e-042.49e-03137
GO:003350022LiverHCCcarbohydrate homeostasis137/7958259/187234.45e-042.98e-03137
GO:000167822LiverHCCcellular glucose homeostasis95/7958172/187234.95e-043.24e-0395
GO:007133112LiverHCCcellular response to hexose stimulus85/7958153/187237.47e-044.52e-0385
GO:007133312LiverHCCcellular response to glucose stimulus84/7958151/187237.57e-044.56e-0384
GO:007030222LiverHCCregulation of stress-activated protein kinase signaling cascade105/7958195/187238.79e-045.20e-03105
GO:007132612LiverHCCcellular response to monosaccharide stimulus85/7958154/187239.78e-045.68e-0385
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
OPRK1SNVMissense_Mutationrs369742092c.853N>Ap.Val285Ilep.V285IP41145protein_codingtolerated(0.68)benign(0.03)TCGA-A2-A0EN-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
OPRK1SNVMissense_Mutationrs200672427c.755N>Ap.Arg252Hisp.R252HP41145protein_codingdeleterious(0)probably_damaging(1)TCGA-AR-A0TV-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
OPRK1SNVMissense_Mutationnovelc.233C>Tp.Ser78Leup.S78LP41145protein_codingtolerated(0.4)benign(0.006)TCGA-E2-A10C-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
OPRK1SNVMissense_Mutationrs199564432c.613N>Ap.Val205Ilep.V205IP41145protein_codingtolerated(0.42)benign(0)TCGA-E2-A1IU-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
OPRK1insertionNonsense_Mutationnovelc.503_504insTATGATTAATCACACATAGGATTTTGTTTCTTCATGCCTACp.Phe169MetfsTer6p.F169Mfs*6P41145protein_codingTCGA-A2-A0EQ-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
OPRK1insertionNonsense_Mutationnovelc.972_973insGGAGAGGAAGGTGTTTTGCTTCTGTAGATCTCAAGGTAp.Leu325GlyfsTer9p.L325Gfs*9P41145protein_codingTCGA-A8-A07U-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapy5-fluorouracilSD
OPRK1insertionNonsense_Mutationnovelc.258-1_258insTATATGTGTGTGTATTATGTGAGGATTCATAGTCTGCTCp.Arg86_Tyr87insIleCysValCysIleMetTerGlyPheIleValCysSerp.R86_Y87insICVCIM*GFIVCSP41145protein_codingTCGA-AO-A0J3-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycyclophosphamideSD
OPRK1SNVMissense_Mutationnovelc.886N>Ap.Val296Metp.V296MP41145protein_codingdeleterious(0)probably_damaging(0.993)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
OPRK1SNVMissense_Mutationc.211N>Ap.Val71Ilep.V71IP41145protein_codingtolerated(0.25)benign(0.051)TCGA-AA-3488-01Colorectumcolon adenocarcinomaMale<65III/IVUnknownUnknownPD
OPRK1SNVMissense_Mutationc.1061N>Ap.Arg354Glnp.R354QP41145protein_codingtolerated(0.8)benign(0)TCGA-AA-3662-01Colorectumcolon adenocarcinomaFemale>=65III/IVChemotherapycapecitabinePR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
4986OPRK1DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTORSJ000113257CHEMBL528694
4986OPRK1DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTORagonist315661269
4986OPRK1DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTORagonistCHEMBL1200794OXYMORPHONE HYDROCHLORIDE
4986OPRK1DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTORoxycodoneOXYCODONE27472837
4986OPRK1DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTORNALTREXONENALTREXONE
4986OPRK1DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTORKP201BENZHYDROCODONE HYDROCHLORIDE
4986OPRK1DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTORNORBINALTORPHIMINENORBINALTORPHIMINE17702750
4986OPRK1DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTORagonistCHEMBL2062267HYDROCODONE BITARTRATE
4986OPRK1DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTORagonist223365926BUTORPHANOL
4986OPRK1DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTORCHLOROXINECHLOROXINE
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