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Gene: ALDH1A1 |
Gene summary for ALDH1A1 |
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Gene information | Species | Human | Gene symbol | ALDH1A1 | Gene ID | 216 |
Gene name | aldehyde dehydrogenase 1 family member A1 | |
Gene Alias | ALDC | |
Cytomap | 9q21.13 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | P00352 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
216 | ALDH1A1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.20e-03 | 2.01e-01 | 0.0155 |
216 | ALDH1A1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.97e-09 | 3.73e-01 | -0.1808 |
216 | ALDH1A1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.19e-06 | 3.94e-01 | 0.0216 |
216 | ALDH1A1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.57e-08 | 5.37e-01 | -0.0811 |
216 | ALDH1A1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.50e-12 | 5.00e-01 | -0.1088 |
216 | ALDH1A1 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.47e-08 | 2.56e-01 | -0.1954 |
216 | ALDH1A1 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.10e-03 | 3.23e-01 | -0.1526 |
216 | ALDH1A1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.37e-28 | 1.00e+00 | -0.059 |
216 | ALDH1A1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.05e-12 | 4.76e-01 | 0.096 |
216 | ALDH1A1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.03e-11 | 9.04e-01 | 0.0171 |
216 | ALDH1A1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.80e-13 | 4.64e-01 | 0.0674 |
216 | ALDH1A1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.05e-47 | 1.55e+00 | 0.294 |
216 | ALDH1A1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.71e-06 | 1.34e+00 | 0.3487 |
216 | ALDH1A1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.97e-17 | 5.88e-01 | 0.3005 |
216 | ALDH1A1 | AEH-subject1 | Human | Endometrium | AEH | 2.43e-38 | -7.93e-01 | -0.3059 |
216 | ALDH1A1 | AEH-subject2 | Human | Endometrium | AEH | 7.86e-28 | -6.94e-01 | -0.2525 |
216 | ALDH1A1 | AEH-subject3 | Human | Endometrium | AEH | 1.56e-26 | -6.69e-01 | -0.2576 |
216 | ALDH1A1 | AEH-subject4 | Human | Endometrium | AEH | 2.26e-09 | -3.80e-01 | -0.2657 |
216 | ALDH1A1 | AEH-subject5 | Human | Endometrium | AEH | 1.69e-47 | -8.24e-01 | -0.2953 |
216 | ALDH1A1 | EEC-subject1 | Human | Endometrium | EEC | 1.00e-38 | -7.75e-01 | -0.2682 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009636 | Colorectum | AD | response to toxic substance | 88/3918 | 262/18723 | 1.12e-06 | 3.72e-05 | 88 |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0098754 | Colorectum | AD | detoxification | 53/3918 | 152/18723 | 4.63e-05 | 7.98e-04 | 53 |
GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
GO:0097237 | Colorectum | AD | cellular response to toxic substance | 44/3918 | 124/18723 | 1.24e-04 | 1.80e-03 | 44 |
GO:0001894 | Colorectum | AD | tissue homeostasis | 81/3918 | 268/18723 | 1.96e-04 | 2.62e-03 | 81 |
GO:1990748 | Colorectum | AD | cellular detoxification | 41/3918 | 116/18723 | 2.29e-04 | 2.97e-03 | 41 |
GO:0034308 | Colorectum | AD | primary alcohol metabolic process | 35/3918 | 102/18723 | 1.16e-03 | 1.05e-02 | 35 |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:0006081 | Colorectum | AD | cellular aldehyde metabolic process | 22/3918 | 60/18723 | 3.64e-03 | 2.60e-02 | 22 |
GO:0106106 | Colorectum | AD | cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
GO:0120161 | Colorectum | AD | regulation of cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
GO:1990845 | Colorectum | AD | adaptive thermogenesis | 46/3918 | 157/18723 | 7.97e-03 | 4.73e-02 | 46 |
GO:00096361 | Colorectum | SER | response to toxic substance | 71/2897 | 262/18723 | 8.63e-07 | 4.07e-05 | 71 |
GO:00972371 | Colorectum | SER | cellular response to toxic substance | 40/2897 | 124/18723 | 2.28e-06 | 9.43e-05 | 40 |
GO:00987541 | Colorectum | SER | detoxification | 46/2897 | 152/18723 | 3.02e-06 | 1.20e-04 | 46 |
GO:19907481 | Colorectum | SER | cellular detoxification | 37/2897 | 116/18723 | 7.20e-06 | 2.48e-04 | 37 |
GO:00018941 | Colorectum | SER | tissue homeostasis | 66/2897 | 268/18723 | 5.87e-05 | 1.37e-03 | 66 |
GO:00602491 | Colorectum | SER | anatomical structure homeostasis | 74/2897 | 314/18723 | 1.01e-04 | 2.13e-03 | 74 |
GO:00060661 | Colorectum | SER | alcohol metabolic process | 79/2897 | 353/18723 | 3.50e-04 | 5.50e-03 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ALDH1A1 | SNV | Missense_Mutation | novel | c.924G>C | p.Arg308Ser | p.R308S | P00352 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ALDH1A1 | SNV | Missense_Mutation | novel | c.311N>T | p.Ala104Val | p.A104V | P00352 | protein_coding | deleterious(0.02) | possibly_damaging(0.712) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ALDH1A1 | SNV | Missense_Mutation | novel | c.326T>C | p.Met109Thr | p.M109T | P00352 | protein_coding | deleterious(0.02) | benign(0.006) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ALDH1A1 | SNV | Missense_Mutation | c.772N>T | p.Ala258Ser | p.A258S | P00352 | protein_coding | tolerated(0.14) | benign(0.261) | TCGA-BH-A0H9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ALDH1A1 | SNV | Missense_Mutation | c.1502C>T | p.Ser501Leu | p.S501L | P00352 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ALDH1A1 | SNV | Missense_Mutation | c.1492N>G | p.Gln498Glu | p.Q498E | P00352 | protein_coding | tolerated(0.19) | benign(0.001) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
ALDH1A1 | SNV | Missense_Mutation | c.250N>A | p.Glu84Lys | p.E84K | P00352 | protein_coding | tolerated(0.18) | possibly_damaging(0.576) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
ALDH1A1 | SNV | Missense_Mutation | novel | c.1497N>C | p.Lys499Asn | p.K499N | P00352 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ALDH1A1 | SNV | Missense_Mutation | c.1436N>T | p.Gly479Val | p.G479V | P00352 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ALDH1A1 | SNV | Missense_Mutation | c.1145T>C | p.Val382Ala | p.V382A | P00352 | protein_coding | deleterious(0) | benign(0.16) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | SJ000044511 | CHEMBL592124 | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | PHTHALIC ACID | PHTHALIC ACID | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | NIFUROXAZIDE | NIFUROXAZIDE | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | GNF-PF-872 | CHEMBL600342 | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | DNDI1417011 | CHEMBL1386434 | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | MONASTROL | MONASTROL | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | E927A | E927A | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | PYRROLIDINE DITHIOCARBAMATE | PYRROLIDINE DITHIOCARBAMATE | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | PHENYLMERCURIC ACETATE | PHENYLMERCURIC ACETATE | ||
216 | ALDH1A1 | DRUGGABLE GENOME, ENZYME | FUROXAN | FUROXAN |
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