Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/TOP1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/TOP1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/TOP1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TOP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/TOP1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/TOP1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/TOP1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TOP1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/TOP1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TOP1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/TOP1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOP1 | SNV | Missense_Mutation | novel | c.62N>G | p.Ser21Cys | p.S21C | P11387 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.615) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
TOP1 | SNV | Missense_Mutation | | c.2123G>A | p.Arg708Gln | p.R708Q | P11387 | protein_coding | deleterious(0) | possibly_damaging(0.538) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
TOP1 | SNV | Missense_Mutation | | c.1700N>C | p.Arg567Thr | p.R567T | P11387 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TOP1 | insertion | Nonsense_Mutation | novel | c.2003_2004insAAGTAGCCCTTAG | p.Lys669SerfsTer4 | p.K669Sfs*4 | P11387 | protein_coding | | | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
TOP1 | insertion | In_Frame_Ins | novel | c.398_399insGGGGTTTACTACTCTAGCAGGAACTTTGAATTTCCTATATAC | p.Ile133delinsMetGlyPheThrThrLeuAlaGlyThrLeuAsnPheLeuTyrThr | p.I133delinsMGFTTLAGTLNFLYT | P11387 | protein_coding | | | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
TOP1 | insertion | In_Frame_Ins | novel | c.2288_2289insTTACACTTCAACAAAACTTTTCGT | p.Tyr763_Glu764insTyrThrSerThrLysLeuPheVal | p.Y763_E764insYTSTKLFV | P11387 | protein_coding | | | TCGA-A8-A0A1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
TOP1 | insertion | Nonsense_Mutation | novel | c.155_155+1insATGTTTTTAAATGAATGTTAATAAGGT | p.Ser52delinsArgCysPheTerMetAsnValAsnLysVal | p.S52delinsRCF*MNVNKV | P11387 | protein_coding | | | TCGA-AO-A03P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | PD |
TOP1 | insertion | Nonsense_Mutation | novel | c.1624_1625insTGTGAGCAGTAGATTCTGATCTTTTTTTAACTCTATTTCATT | p.Pro542delinsLeuTerAlaValAspSerAspLeuPheLeuThrLeuPheHisSer | p.P542delinsL*AVDSDLFLTLFHS | P11387 | protein_coding | | | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
TOP1 | insertion | Frame_Shift_Ins | novel | c.749_750insAGCAGTTTCCTTTTCCTGGAGCTCAGCCTTTT | p.Ser250ArgfsTer18 | p.S250Rfs*18 | P11387 | protein_coding | | | TCGA-B6-A0IE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TOP1 | insertion | Nonsense_Mutation | novel | c.803_804insAGGGTAGCCTTTGACATGCCTCCTGTTGGCAG | p.Tyr268Ter | p.Y268* | P11387 | protein_coding | | | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7150 | TOP1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | SOPHORIDINE | SOPHORIDINE | 21807514 |
7150 | TOP1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | NKTR-102 | ETIRINOTECAN PEGOL | |
7150 | TOP1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 249565941 | | |
7150 | TOP1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | 6-OXIMOTRYPTANTHRIN | CHEMBL308106 | 20373766 |
7150 | TOP1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | 10-(4-PYRIDYL)CAMPTOTHECIN | CHEMBL1762593 | 21333532 |
7150 | TOP1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | IRINOTECAN | IRINOTECAN | 19775480 |
7150 | TOP1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | CALOTHRIXIN B | CALOTHRIXIN B | 19203291 |
7150 | TOP1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | Daniquidone | DANIQUIDONE | |
7150 | TOP1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | QUERCETIN | QUERCETIN | 8759170 |
7150 | TOP1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | AESCULIOSIDE IIK | AESCULIOSIDE IIK | 20371180 |