Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/THRB_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/THRB_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/THRB_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/THRB_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/THRB_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0030522 | Colorectum | AD | intracellular receptor signaling pathway | 87/3918 | 265/18723 | 3.69e-06 | 1.03e-04 | 87 |
GO:0009755 | Colorectum | AD | hormone-mediated signaling pathway | 64/3918 | 190/18723 | 2.78e-05 | 5.24e-04 | 64 |
GO:0051402 | Colorectum | AD | neuron apoptotic process | 77/3918 | 246/18723 | 8.07e-05 | 1.28e-03 | 77 |
GO:00709971 | Colorectum | SER | neuron death | 84/2897 | 361/18723 | 5.76e-05 | 1.35e-03 | 84 |
GO:00097551 | Colorectum | SER | hormone-mediated signaling pathway | 49/2897 | 190/18723 | 1.54e-04 | 3.00e-03 | 49 |
GO:00514021 | Colorectum | SER | neuron apoptotic process | 60/2897 | 246/18723 | 1.65e-04 | 3.13e-03 | 60 |
GO:00305221 | Colorectum | SER | intracellular receptor signaling pathway | 63/2897 | 265/18723 | 2.47e-04 | 4.20e-03 | 63 |
GO:00305222 | Colorectum | MSS | intracellular receptor signaling pathway | 84/3467 | 265/18723 | 1.47e-07 | 6.79e-06 | 84 |
GO:00097552 | Colorectum | MSS | hormone-mediated signaling pathway | 63/3467 | 190/18723 | 9.26e-07 | 3.23e-05 | 63 |
GO:00709972 | Colorectum | MSS | neuron death | 97/3467 | 361/18723 | 5.21e-05 | 9.31e-04 | 97 |
GO:00514022 | Colorectum | MSS | neuron apoptotic process | 66/3467 | 246/18723 | 7.94e-04 | 8.36e-03 | 66 |
GO:00305223 | Colorectum | FAP | intracellular receptor signaling pathway | 67/2622 | 265/18723 | 6.84e-07 | 3.28e-05 | 67 |
GO:00097554 | Colorectum | FAP | hormone-mediated signaling pathway | 51/2622 | 190/18723 | 2.23e-06 | 8.87e-05 | 51 |
GO:00709974 | Colorectum | FAP | neuron death | 81/2622 | 361/18723 | 8.35e-06 | 2.46e-04 | 81 |
GO:00514024 | Colorectum | FAP | neuron apoptotic process | 55/2622 | 246/18723 | 2.42e-04 | 3.37e-03 | 55 |
GO:0060428 | Colorectum | FAP | lung epithelium development | 12/2622 | 37/18723 | 3.43e-03 | 2.48e-02 | 12 |
GO:0030323 | Colorectum | FAP | respiratory tube development | 39/2622 | 181/18723 | 3.60e-03 | 2.58e-02 | 39 |
GO:0048593 | Colorectum | FAP | camera-type eye morphogenesis | 28/2622 | 120/18723 | 3.98e-03 | 2.76e-02 | 28 |
GO:0030324 | Colorectum | FAP | lung development | 38/2622 | 177/18723 | 4.28e-03 | 2.93e-02 | 38 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04919 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa049191 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa049192 | Colorectum | SER | Thyroid hormone signaling pathway | 40/1580 | 121/8465 | 1.02e-04 | 1.06e-03 | 7.67e-04 | 40 |
hsa049193 | Colorectum | SER | Thyroid hormone signaling pathway | 40/1580 | 121/8465 | 1.02e-04 | 1.06e-03 | 7.67e-04 | 40 |
hsa049194 | Colorectum | MSS | Thyroid hormone signaling pathway | 46/1875 | 121/8465 | 5.04e-05 | 4.97e-04 | 3.05e-04 | 46 |
hsa049195 | Colorectum | MSS | Thyroid hormone signaling pathway | 46/1875 | 121/8465 | 5.04e-05 | 4.97e-04 | 3.05e-04 | 46 |
hsa049198 | Colorectum | FAP | Thyroid hormone signaling pathway | 41/1404 | 121/8465 | 2.28e-06 | 4.28e-05 | 2.60e-05 | 41 |
hsa049199 | Colorectum | FAP | Thyroid hormone signaling pathway | 41/1404 | 121/8465 | 2.28e-06 | 4.28e-05 | 2.60e-05 | 41 |
hsa0491910 | Colorectum | CRC | Thyroid hormone signaling pathway | 35/1091 | 121/8465 | 2.05e-06 | 6.85e-05 | 4.64e-05 | 35 |
hsa0491911 | Colorectum | CRC | Thyroid hormone signaling pathway | 35/1091 | 121/8465 | 2.05e-06 | 6.85e-05 | 4.64e-05 | 35 |
hsa0491912 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
hsa0491913 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
hsa0491914 | Lung | IAC | Thyroid hormone signaling pathway | 27/1053 | 121/8465 | 1.61e-03 | 9.49e-03 | 6.30e-03 | 27 |
hsa0491915 | Lung | IAC | Thyroid hormone signaling pathway | 27/1053 | 121/8465 | 1.61e-03 | 9.49e-03 | 6.30e-03 | 27 |
hsa0491921 | Lung | AIS | Thyroid hormone signaling pathway | 27/961 | 121/8465 | 3.92e-04 | 3.85e-03 | 2.47e-03 | 27 |
hsa0491931 | Lung | AIS | Thyroid hormone signaling pathway | 27/961 | 121/8465 | 3.92e-04 | 3.85e-03 | 2.47e-03 | 27 |
hsa0491941 | Lung | MIAC | Thyroid hormone signaling pathway | 16/507 | 121/8465 | 2.23e-03 | 2.03e-02 | 1.47e-02 | 16 |
hsa0491951 | Lung | MIAC | Thyroid hormone signaling pathway | 16/507 | 121/8465 | 2.23e-03 | 2.03e-02 | 1.47e-02 | 16 |
hsa0491924 | Prostate | BPH | Thyroid hormone signaling pathway | 39/1718 | 121/8465 | 1.27e-03 | 5.58e-03 | 3.45e-03 | 39 |
hsa04919111 | Prostate | BPH | Thyroid hormone signaling pathway | 39/1718 | 121/8465 | 1.27e-03 | 5.58e-03 | 3.45e-03 | 39 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THRB | SNV | Missense_Mutation | | c.1099N>A | p.Asp367Asn | p.D367N | P10828 | protein_coding | deleterious(0) | benign(0.019) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THRB | SNV | Missense_Mutation | novel | c.1126N>A | p.Val376Ile | p.V376I | P10828 | protein_coding | tolerated(1) | benign(0.045) | TCGA-A8-A08G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
THRB | SNV | Missense_Mutation | | c.104C>A | p.Ala35Asp | p.A35D | P10828 | protein_coding | tolerated_low_confidence(0.54) | benign(0) | TCGA-E2-A1IE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD |
THRB | SNV | Missense_Mutation | novel | c.50N>A | p.Pro17Gln | p.P17Q | P10828 | protein_coding | tolerated_low_confidence(0.24) | benign(0.099) | TCGA-E9-A1NA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
THRB | insertion | Frame_Shift_Ins | novel | c.994_995insATGTCACCCCTTGT | p.Gly332AspfsTer10 | p.G332Dfs*10 | P10828 | protein_coding | | | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
THRB | SNV | Missense_Mutation | | c.1147C>T | p.Arg383Cys | p.R383C | P10828 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
THRB | SNV | Missense_Mutation | rs556429294 | c.137G>A | p.Arg46His | p.R46H | P10828 | protein_coding | deleterious_low_confidence(0.03) | benign(0) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
THRB | SNV | Missense_Mutation | | c.497N>A | p.Phe166Tyr | p.F166Y | P10828 | protein_coding | tolerated(0.16) | benign(0.156) | TCGA-AA-3692-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | PD |
THRB | SNV | Missense_Mutation | | c.97N>C | p.Ser33Pro | p.S33P | P10828 | protein_coding | deleterious_low_confidence(0) | benign(0.044) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
THRB | SNV | Missense_Mutation | | c.1348C>A | p.Leu450Ile | p.L450I | P10828 | protein_coding | tolerated(0.22) | probably_damaging(0.947) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7068 | THRB | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | INAMRINONE | INAMRINONE | |
7068 | THRB | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | MB07811 | MB07811 | |
7068 | THRB | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | METHYLENE BLUE CHLORIDE HYDRATE | METHYLENE BLUE | |
7068 | THRB | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | NSC-9037 | CHEMBL1451216 | |
7068 | THRB | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | agonist | CHEMBL559 | DEXTROTHYROXINE | |
7068 | THRB | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | GNF-PF-1852 | CHEMBL533293 | |
7068 | THRB | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | BCT303 | | |
7068 | THRB | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | ANAZOLENE | ANAZOLENE | |
7068 | THRB | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | CARMINOMYCIN | CARUBICIN | |
7068 | THRB | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | PICEATANNOL | PICEATANNOL | |