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Gene: PCLO |
Gene summary for PCLO |
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Gene information | Species | Human | Gene symbol | PCLO | Gene ID | 27445 |
Gene name | piccolo presynaptic cytomatrix protein | |
Gene Alias | ACZ | |
Cytomap | 7q21.11 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q9Y6V0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27445 | PCLO | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.61e-04 | -3.06e-01 | 0.0155 |
27445 | PCLO | HTA11_347_2000001011 | Human | Colorectum | AD | 6.10e-07 | 4.87e-01 | -0.1954 |
27445 | PCLO | HTA11_866_3004761011 | Human | Colorectum | AD | 2.93e-04 | -3.55e-01 | 0.096 |
27445 | PCLO | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.37e-02 | -3.55e-01 | 0.0338 |
27445 | PCLO | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.12e-06 | -3.06e-01 | 0.0674 |
27445 | PCLO | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.85e-16 | -4.36e-01 | 0.294 |
27445 | PCLO | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.66e-02 | 5.33e-01 | 0.281 |
27445 | PCLO | A015-C-203 | Human | Colorectum | FAP | 1.60e-09 | -1.04e-01 | -0.1294 |
27445 | PCLO | A002-C-201 | Human | Colorectum | FAP | 7.33e-03 | -9.02e-02 | 0.0324 |
27445 | PCLO | A001-C-108 | Human | Colorectum | FAP | 4.46e-03 | 3.11e-02 | -0.0272 |
27445 | PCLO | A002-C-205 | Human | Colorectum | FAP | 6.02e-07 | 7.51e-02 | -0.1236 |
27445 | PCLO | A015-C-006 | Human | Colorectum | FAP | 1.63e-03 | -2.59e-02 | -0.0994 |
27445 | PCLO | A015-C-106 | Human | Colorectum | FAP | 5.64e-03 | -6.35e-02 | -0.0511 |
27445 | PCLO | A002-C-114 | Human | Colorectum | FAP | 3.97e-04 | -1.29e-01 | -0.1561 |
27445 | PCLO | A015-C-104 | Human | Colorectum | FAP | 4.38e-08 | -6.65e-02 | -0.1899 |
27445 | PCLO | A002-C-016 | Human | Colorectum | FAP | 8.50e-08 | -6.14e-03 | 0.0521 |
27445 | PCLO | A002-C-116 | Human | Colorectum | FAP | 3.76e-09 | -2.58e-01 | -0.0452 |
27445 | PCLO | A014-C-008 | Human | Colorectum | FAP | 1.54e-04 | 1.04e-01 | -0.191 |
27445 | PCLO | A018-E-020 | Human | Colorectum | FAP | 1.00e-04 | -1.28e-01 | -0.2034 |
27445 | PCLO | F034 | Human | Colorectum | FAP | 5.30e-06 | 3.76e-02 | -0.0665 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0051648 | Colorectum | AD | vesicle localization | 59/3918 | 177/18723 | 7.83e-05 | 1.25e-03 | 59 |
GO:0043954 | Colorectum | AD | cellular component maintenance | 26/3918 | 61/18723 | 1.04e-04 | 1.56e-03 | 26 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0030073 | Colorectum | AD | insulin secretion | 61/3918 | 195/18723 | 4.28e-04 | 4.81e-03 | 61 |
GO:0015833 | Colorectum | AD | peptide transport | 77/3918 | 264/18723 | 8.90e-04 | 8.60e-03 | 77 |
GO:0030072 | Colorectum | AD | peptide hormone secretion | 68/3918 | 236/18723 | 2.39e-03 | 1.85e-02 | 68 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:0034331 | Colorectum | AD | cell junction maintenance | 15/3918 | 35/18723 | 2.78e-03 | 2.09e-02 | 15 |
GO:0002790 | Colorectum | AD | peptide secretion | 69/3918 | 242/18723 | 2.97e-03 | 2.22e-02 | 69 |
GO:0017157 | Colorectum | AD | regulation of exocytosis | 59/3918 | 202/18723 | 3.20e-03 | 2.36e-02 | 59 |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
GO:1902414 | Colorectum | AD | protein localization to cell junction | 31/3918 | 94/18723 | 4.30e-03 | 2.95e-02 | 31 |
GO:0099003 | Colorectum | AD | vesicle-mediated transport in synapse | 57/3918 | 200/18723 | 6.53e-03 | 4.06e-02 | 57 |
GO:00343292 | Colorectum | MSS | cell junction assembly | 120/3467 | 420/18723 | 2.51e-07 | 1.07e-05 | 120 |
GO:00093062 | Colorectum | MSS | protein secretion | 98/3467 | 359/18723 | 2.43e-05 | 5.09e-04 | 98 |
GO:00355922 | Colorectum | MSS | establishment of protein localization to extracellular region | 98/3467 | 360/18723 | 2.75e-05 | 5.58e-04 | 98 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04911 | Colorectum | FAP | Insulin secretion | 23/1404 | 86/8465 | 1.12e-02 | 3.92e-02 | 2.38e-02 | 23 |
hsa049111 | Colorectum | FAP | Insulin secretion | 23/1404 | 86/8465 | 1.12e-02 | 3.92e-02 | 2.38e-02 | 23 |
hsa049112 | Colorectum | CRC | Insulin secretion | 20/1091 | 86/8465 | 5.61e-03 | 2.88e-02 | 1.95e-02 | 20 |
hsa049113 | Colorectum | CRC | Insulin secretion | 20/1091 | 86/8465 | 5.61e-03 | 2.88e-02 | 1.95e-02 | 20 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCLO | SNV | Missense_Mutation | c.11817A>C | p.Gln3939His | p.Q3939H | Q9Y6V0 | protein_coding | tolerated(0.08) | possibly_damaging(0.621) | TCGA-IN-A6RO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | irinotecan | PD | |
PCLO | SNV | Missense_Mutation | novel | c.3598N>G | p.Leu1200Val | p.L1200V | Q9Y6V0 | protein_coding | tolerated_low_confidence(0.29) | benign(0.003) | TCGA-IN-A7NT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | leucovorin | SD |
PCLO | SNV | Missense_Mutation | novel | c.13437N>C | p.Gln4479His | p.Q4479H | Q9Y6V0 | protein_coding | deleterious(0.04) | benign(0.031) | TCGA-R5-A7ZE-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
PCLO | SNV | Missense_Mutation | novel | c.8570T>C | p.Leu2857Pro | p.L2857P | Q9Y6V0 | protein_coding | deleterious(0.01) | possibly_damaging(0.742) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PCLO | SNV | Missense_Mutation | c.6038N>G | p.Glu2013Gly | p.E2013G | Q9Y6V0 | protein_coding | deleterious(0) | possibly_damaging(0.599) | TCGA-R5-A805-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
PCLO | SNV | Missense_Mutation | novel | c.11206A>C | p.Thr3736Pro | p.T3736P | Q9Y6V0 | protein_coding | tolerated(0.11) | benign(0.277) | TCGA-RD-A7BT-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
PCLO | SNV | Missense_Mutation | c.7873N>T | p.Pro2625Ser | p.P2625S | Q9Y6V0 | protein_coding | tolerated(0.27) | benign(0.011) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
PCLO | SNV | Missense_Mutation | novel | c.2342N>A | p.Ser781Tyr | p.S781Y | Q9Y6V0 | protein_coding | deleterious_low_confidence(0.02) | benign(0.313) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
PCLO | SNV | Missense_Mutation | rs371995456 | c.13316N>A | p.Arg4439His | p.R4439H | Q9Y6V0 | protein_coding | tolerated(0.07) | possibly_damaging(0.643) | TCGA-VQ-A8PB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR |
PCLO | SNV | Missense_Mutation | novel | c.4204N>G | p.Ser1402Gly | p.S1402G | Q9Y6V0 | protein_coding | tolerated(0.1) | probably_damaging(0.971) | TCGA-VQ-A8PB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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