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Gene: ZSWIM6 |
Gene summary for ZSWIM6 |
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Gene information | Species | Human | Gene symbol | ZSWIM6 | Gene ID | 57688 |
Gene name | zinc finger SWIM-type containing 6 | |
Gene Alias | AFND | |
Cytomap | 5q12.1 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q9HCJ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57688 | ZSWIM6 | CCI_1 | Human | Cervix | CC | 1.82e-11 | 1.09e+00 | 0.528 |
57688 | ZSWIM6 | CCI_2 | Human | Cervix | CC | 5.17e-22 | 2.76e+00 | 0.5249 |
57688 | ZSWIM6 | CCI_3 | Human | Cervix | CC | 3.00e-36 | 1.73e+00 | 0.516 |
57688 | ZSWIM6 | CCII_1 | Human | Cervix | CC | 5.14e-05 | 3.32e-01 | 0.3249 |
57688 | ZSWIM6 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.03e-23 | -7.01e-01 | 0.0155 |
57688 | ZSWIM6 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.80e-03 | -7.50e-01 | 0.0216 |
57688 | ZSWIM6 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.22e-18 | 7.86e-01 | -0.1954 |
57688 | ZSWIM6 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.34e-06 | 6.12e-01 | -0.2196 |
57688 | ZSWIM6 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.01e-02 | 3.53e-01 | -0.1526 |
57688 | ZSWIM6 | HTA11_7862_2000001011 | Human | Colorectum | AD | 8.45e-06 | -6.66e-01 | -0.0179 |
57688 | ZSWIM6 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.88e-18 | -7.43e-01 | 0.096 |
57688 | ZSWIM6 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.43e-03 | -5.84e-01 | 0.0446 |
57688 | ZSWIM6 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.34e-08 | -9.26e-01 | 0.0528 |
57688 | ZSWIM6 | HTA11_6801_2000001011 | Human | Colorectum | SER | 7.89e-04 | -8.98e-01 | 0.0171 |
57688 | ZSWIM6 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.24e-07 | -4.89e-01 | 0.0674 |
57688 | ZSWIM6 | HTA11_6818_2000001011 | Human | Colorectum | AD | 6.06e-05 | -5.45e-01 | 0.0112 |
57688 | ZSWIM6 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.19e-26 | -7.57e-01 | 0.294 |
57688 | ZSWIM6 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.24e-22 | -7.46e-01 | 0.3859 |
57688 | ZSWIM6 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.10e-09 | -7.88e-01 | 0.2585 |
57688 | ZSWIM6 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.97e-74 | -1.30e+00 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00309003 | Cervix | CC | forebrain development | 64/2311 | 379/18723 | 5.53e-03 | 3.19e-02 | 64 |
GO:0030900 | Colorectum | FAP | forebrain development | 70/2622 | 379/18723 | 8.64e-03 | 4.98e-02 | 70 |
GO:00309001 | Colorectum | CRC | forebrain development | 66/2078 | 379/18723 | 1.36e-04 | 2.57e-03 | 66 |
GO:0021879 | Colorectum | CRC | forebrain neuron differentiation | 12/2078 | 42/18723 | 1.55e-03 | 1.63e-02 | 12 |
GO:0021537 | Colorectum | CRC | telencephalon development | 43/2078 | 248/18723 | 2.01e-03 | 2.01e-02 | 43 |
GO:0021872 | Colorectum | CRC | forebrain generation of neurons | 13/2078 | 51/18723 | 3.09e-03 | 2.73e-02 | 13 |
GO:0021953 | Colorectum | CRC | central nervous system neuron differentiation | 29/2078 | 162/18723 | 6.36e-03 | 4.62e-02 | 29 |
GO:00309002 | Lung | IAC | forebrain development | 61/2061 | 379/18723 | 1.52e-03 | 1.61e-02 | 61 |
GO:003090011 | Lung | AIS | forebrain development | 55/1849 | 379/18723 | 2.37e-03 | 2.48e-02 | 55 |
GO:00309005 | Oral cavity | EOLP | forebrain development | 68/2218 | 379/18723 | 2.97e-04 | 2.79e-03 | 68 |
GO:003090013 | Oral cavity | NEOLP | forebrain development | 67/2005 | 379/18723 | 2.54e-05 | 3.99e-04 | 67 |
GO:00219532 | Oral cavity | NEOLP | central nervous system neuron differentiation | 30/2005 | 162/18723 | 1.96e-03 | 1.32e-02 | 30 |
GO:00215371 | Oral cavity | NEOLP | telencephalon development | 40/2005 | 248/18723 | 5.50e-03 | 2.93e-02 | 40 |
GO:00309004 | Prostate | BPH | forebrain development | 80/3107 | 379/18723 | 1.19e-02 | 4.82e-02 | 80 |
GO:003090012 | Prostate | Tumor | forebrain development | 86/3246 | 379/18723 | 4.22e-03 | 2.11e-02 | 86 |
GO:00309006 | Skin | AK | forebrain development | 66/1910 | 379/18723 | 1.02e-05 | 2.17e-04 | 66 |
GO:00215372 | Skin | AK | telencephalon development | 42/1910 | 248/18723 | 7.04e-04 | 6.01e-03 | 42 |
GO:003090014 | Skin | SCCIS | forebrain development | 34/919 | 379/18723 | 5.35e-04 | 8.26e-03 | 34 |
GO:002153711 | Skin | SCCIS | telencephalon development | 23/919 | 248/18723 | 2.63e-03 | 2.48e-02 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZSWIM6 | insertion | Frame_Shift_Ins | novel | c.1742_1743insC | p.Arg583GlnfsTer12 | p.R583Qfs*12 | Q9HCJ5 | protein_coding | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
ZSWIM6 | SNV | Missense_Mutation | novel | c.1370G>A | p.Cys457Tyr | p.C457Y | Q9HCJ5 | protein_coding | tolerated(0.05) | benign(0.02) | TCGA-2Y-A9H9-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Targeted Molecular therapy | sorafenib | PD |
ZSWIM6 | SNV | Missense_Mutation | novel | c.403G>T | p.Gly135Cys | p.G135C | Q9HCJ5 | protein_coding | tolerated_low_confidence(0.21) | benign(0.123) | TCGA-CC-5262-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZSWIM6 | SNV | Missense_Mutation | novel | c.1838N>T | p.Glu613Val | p.E613V | Q9HCJ5 | protein_coding | tolerated(0.05) | possibly_damaging(0.69) | TCGA-DD-AACJ-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZSWIM6 | SNV | Missense_Mutation | novel | c.202N>T | p.Pro68Ser | p.P68S | Q9HCJ5 | protein_coding | tolerated_low_confidence(0.87) | benign(0) | TCGA-EP-A2KB-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZSWIM6 | SNV | Missense_Mutation | rs557637276 | c.2327N>G | p.Ser776Cys | p.S776C | Q9HCJ5 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-UB-A7MF-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
ZSWIM6 | SNV | Missense_Mutation | novel | c.2065N>T | p.Thr689Ser | p.T689S | Q9HCJ5 | protein_coding | tolerated(0.74) | benign(0.013) | TCGA-XR-A8TF-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZSWIM6 | SNV | Missense_Mutation | novel | c.3127C>T | p.Pro1043Ser | p.P1043S | Q9HCJ5 | protein_coding | tolerated(0.08) | probably_damaging(0.915) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZSWIM6 | SNV | Missense_Mutation | novel | c.1600N>T | p.Ile534Phe | p.I534F | Q9HCJ5 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-66-2727-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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