![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZSCAN29 |
Gene summary for ZSCAN29 |
![]() |
Gene information | Species | Human | Gene symbol | ZSCAN29 | Gene ID | 146050 |
Gene name | zinc finger and SCAN domain containing 29 | |
Gene Alias | ZNF690 | |
Cytomap | 15q15.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q05BJ4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
146050 | ZSCAN29 | HCC1_Meng | Human | Liver | HCC | 1.86e-33 | 4.22e-02 | 0.0246 |
146050 | ZSCAN29 | HCC2_Meng | Human | Liver | HCC | 1.15e-08 | 6.26e-02 | 0.0107 |
146050 | ZSCAN29 | HCC1 | Human | Liver | HCC | 3.26e-04 | 2.30e+00 | 0.5336 |
146050 | ZSCAN29 | HCC2 | Human | Liver | HCC | 5.38e-12 | 2.95e+00 | 0.5341 |
146050 | ZSCAN29 | S015 | Human | Liver | HCC | 1.04e-02 | 1.21e-01 | 0.2375 |
146050 | ZSCAN29 | S016 | Human | Liver | HCC | 1.26e-06 | 2.14e-01 | 0.2243 |
146050 | ZSCAN29 | S027 | Human | Liver | HCC | 1.35e-04 | 4.57e-01 | 0.2446 |
146050 | ZSCAN29 | S028 | Human | Liver | HCC | 4.73e-18 | 5.09e-01 | 0.2503 |
146050 | ZSCAN29 | S029 | Human | Liver | HCC | 2.09e-09 | 3.21e-01 | 0.2581 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZSCAN29 | SNV | Missense_Mutation | novel | c.1084N>T | p.Pro362Ser | p.P362S | Q8IWY8 | protein_coding | tolerated(0.17) | benign(0.054) | TCGA-KB-A6F7-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
ZSCAN29 | SNV | Missense_Mutation | rs369750925 | c.1417N>T | p.Arg473Trp | p.R473W | Q8IWY8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-RD-A7C1-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZSCAN29 | SNV | Missense_Mutation | novel | c.133N>T | p.Arg45Trp | p.R45W | Q8IWY8 | protein_coding | deleterious(0.03) | benign(0.028) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
ZSCAN29 | SNV | Missense_Mutation | rs151307138 | c.394N>C | p.Ser132Arg | p.S132R | Q8IWY8 | protein_coding | tolerated(0.23) | benign(0.193) | TCGA-VQ-AA64-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
ZSCAN29 | SNV | Missense_Mutation | novel | c.1538C>T | p.Pro513Leu | p.P513L | Q8IWY8 | protein_coding | tolerated(0.6) | benign(0) | TCGA-DJ-A3UM-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |