![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF90 |
Gene summary for ZNF90 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF90 | Gene ID | 7643 |
Gene name | zinc finger protein 90 | |
Gene Alias | HTF9 | |
Cytomap | 19p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q03938 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7643 | ZNF90 | GSM4909281 | Human | Breast | IDC | 5.60e-21 | 5.29e-01 | 0.21 |
7643 | ZNF90 | GSM4909311 | Human | Breast | IDC | 8.34e-04 | -9.27e-02 | 0.1534 |
7643 | ZNF90 | GSM4909319 | Human | Breast | IDC | 8.07e-06 | -1.15e-01 | 0.1563 |
7643 | ZNF90 | GSM4909320 | Human | Breast | IDC | 4.52e-08 | 5.89e-01 | 0.1575 |
7643 | ZNF90 | GSM4909321 | Human | Breast | IDC | 1.46e-06 | 2.87e-01 | 0.1559 |
7643 | ZNF90 | DCIS2 | Human | Breast | DCIS | 2.19e-03 | -8.95e-02 | 0.0085 |
7643 | ZNF90 | EEC-subject2 | Human | Endometrium | EEC | 3.98e-03 | -1.25e-01 | -0.2607 |
7643 | ZNF90 | EEC-subject3 | Human | Endometrium | EEC | 1.09e-10 | -1.30e-01 | -0.2525 |
7643 | ZNF90 | EEC-subject5 | Human | Endometrium | EEC | 1.82e-05 | -1.36e-01 | -0.249 |
7643 | ZNF90 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.14e-50 | 1.21e+00 | -0.1869 |
7643 | ZNF90 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.60e-52 | 1.28e+00 | -0.1875 |
7643 | ZNF90 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.61e-70 | 1.41e+00 | -0.1883 |
7643 | ZNF90 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.35e-35 | 8.85e-01 | -0.1934 |
7643 | ZNF90 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.20e-61 | 1.17e+00 | -0.1917 |
7643 | ZNF90 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.80e-49 | 1.07e+00 | -0.1916 |
7643 | ZNF90 | S41 | Human | Liver | Cirrhotic | 1.99e-06 | -7.80e-01 | -0.0343 |
7643 | ZNF90 | S42 | Human | Liver | HCC | 1.07e-02 | -6.48e-01 | -0.0103 |
7643 | ZNF90 | S43 | Human | Liver | Cirrhotic | 6.77e-38 | -7.67e-01 | -0.0187 |
7643 | ZNF90 | S44 | Human | Liver | HCC | 2.02e-02 | -7.80e-01 | -0.0083 |
7643 | ZNF90 | HCC1_Meng | Human | Liver | HCC | 7.20e-36 | -7.70e-01 | 0.0246 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF90 | SNV | Missense_Mutation | c.1264N>C | p.Glu422Gln | p.E422Q | Q03938 | protein_coding | deleterious(0.04) | possibly_damaging(0.614) | TCGA-62-A46O-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF90 | SNV | Missense_Mutation | c.1450C>G | p.Gln484Glu | p.Q484E | Q03938 | protein_coding | tolerated(1) | benign(0) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF90 | SNV | Missense_Mutation | novel | c.1196N>A | p.Cys399Tyr | p.C399Y | Q03938 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZNF90 | SNV | Missense_Mutation | novel | c.493N>G | p.Ile165Val | p.I165V | Q03938 | protein_coding | tolerated(0.16) | benign(0.215) | TCGA-86-7711-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD |
ZNF90 | SNV | Missense_Mutation | c.1523C>T | p.Pro508Leu | p.P508L | Q03938 | protein_coding | tolerated(0.08) | benign(0.068) | TCGA-86-8278-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | etoposide | SD | |
ZNF90 | SNV | Missense_Mutation | c.872N>A | p.Gly291Asp | p.G291D | Q03938 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-99-8025-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | gemzar | SD | |
ZNF90 | SNV | Missense_Mutation | c.90N>T | p.Arg30Ser | p.R30S | Q03938 | protein_coding | deleterious(0) | possibly_damaging(0.739) | TCGA-39-5024-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD | |
ZNF90 | SNV | Missense_Mutation | novel | c.1473N>T | p.Lys491Asn | p.K491N | Q03938 | protein_coding | tolerated(1) | benign(0.006) | TCGA-39-5034-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF90 | SNV | Missense_Mutation | novel | c.1514N>A | p.Gly505Glu | p.G505E | Q03938 | protein_coding | tolerated(0.05) | benign(0.046) | TCGA-85-8350-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF90 | SNV | Missense_Mutation | novel | c.908N>G | p.His303Arg | p.H303R | Q03938 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-85-8351-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |