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Gene: ZNF827 |
Gene summary for ZNF827 |
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Gene information | Species | Human | Gene symbol | ZNF827 | Gene ID | 152485 |
Gene name | zinc finger protein 827 | |
Gene Alias | ZNF827 | |
Cytomap | 4q31.21-q31.22 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KSR1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
152485 | ZNF827 | LZE4T | Human | Esophagus | ESCC | 2.79e-02 | 1.97e-01 | 0.0811 |
152485 | ZNF827 | LZE8T | Human | Esophagus | ESCC | 4.06e-02 | 9.99e-02 | 0.067 |
152485 | ZNF827 | LZE24T | Human | Esophagus | ESCC | 1.98e-03 | 9.08e-02 | 0.0596 |
152485 | ZNF827 | P2T-E | Human | Esophagus | ESCC | 2.63e-33 | 5.23e-01 | 0.1177 |
152485 | ZNF827 | P4T-E | Human | Esophagus | ESCC | 3.19e-15 | 1.91e-01 | 0.1323 |
152485 | ZNF827 | P8T-E | Human | Esophagus | ESCC | 2.56e-10 | 2.27e-01 | 0.0889 |
152485 | ZNF827 | P9T-E | Human | Esophagus | ESCC | 4.82e-09 | 1.31e-01 | 0.1131 |
152485 | ZNF827 | P10T-E | Human | Esophagus | ESCC | 4.25e-13 | 2.24e-01 | 0.116 |
152485 | ZNF827 | P11T-E | Human | Esophagus | ESCC | 5.15e-09 | 2.91e-01 | 0.1426 |
152485 | ZNF827 | P12T-E | Human | Esophagus | ESCC | 1.13e-20 | 4.85e-01 | 0.1122 |
152485 | ZNF827 | P15T-E | Human | Esophagus | ESCC | 1.21e-23 | 4.32e-01 | 0.1149 |
152485 | ZNF827 | P16T-E | Human | Esophagus | ESCC | 7.96e-15 | 3.14e-01 | 0.1153 |
152485 | ZNF827 | P20T-E | Human | Esophagus | ESCC | 1.66e-08 | 1.52e-01 | 0.1124 |
152485 | ZNF827 | P21T-E | Human | Esophagus | ESCC | 1.26e-05 | 1.19e-01 | 0.1617 |
152485 | ZNF827 | P22T-E | Human | Esophagus | ESCC | 1.49e-03 | 9.59e-02 | 0.1236 |
152485 | ZNF827 | P23T-E | Human | Esophagus | ESCC | 1.15e-06 | 1.62e-01 | 0.108 |
152485 | ZNF827 | P26T-E | Human | Esophagus | ESCC | 2.80e-12 | 2.86e-01 | 0.1276 |
152485 | ZNF827 | P27T-E | Human | Esophagus | ESCC | 6.51e-08 | 2.48e-01 | 0.1055 |
152485 | ZNF827 | P28T-E | Human | Esophagus | ESCC | 1.40e-05 | 2.05e-01 | 0.1149 |
152485 | ZNF827 | P30T-E | Human | Esophagus | ESCC | 8.05e-05 | 2.24e-01 | 0.137 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF827 | SNV | Missense_Mutation | novel | c.815C>A | p.Pro272His | p.P272H | Q17R98 | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-86-7701-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD |
ZNF827 | SNV | Missense_Mutation | rs371905111 | c.1624G>T | p.Asp542Tyr | p.D542Y | Q17R98 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.775) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF827 | SNV | Missense_Mutation | novel | c.2665G>C | p.Asp889His | p.D889H | Q17R98 | protein_coding | tolerated(0.15) | possibly_damaging(0.707) | TCGA-NJ-A4YF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF827 | SNV | Missense_Mutation | novel | c.470N>T | p.Ser157Phe | p.S157F | Q17R98 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF827 | SNV | Missense_Mutation | novel | c.241N>G | p.Leu81Val | p.L81V | Q17R98 | protein_coding | deleterious(0) | benign(0.138) | TCGA-22-5479-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
ZNF827 | SNV | Missense_Mutation | novel | c.601A>T | p.Thr201Ser | p.T201S | Q17R98 | protein_coding | tolerated(0.74) | benign(0.003) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF827 | SNV | Missense_Mutation | c.1368N>T | p.Gln456His | p.Q456H | Q17R98 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-39-5035-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF827 | SNV | Missense_Mutation | rs771386798 | c.373C>T | p.Arg125Trp | p.R125W | Q17R98 | protein_coding | deleterious(0) | benign(0.003) | TCGA-43-8115-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
ZNF827 | SNV | Missense_Mutation | novel | c.2835G>C | p.Lys945Asn | p.K945N | Q17R98 | protein_coding | tolerated(0.06) | possibly_damaging(0.864) | TCGA-56-7221-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF827 | SNV | Missense_Mutation | c.196N>A | p.Ser66Thr | p.S66T | Q17R98 | protein_coding | deleterious(0) | benign(0.041) | TCGA-66-2767-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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