![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF483 |
Gene summary for ZNF483 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF483 | Gene ID | 158399 |
Gene name | zinc finger protein 483 | |
Gene Alias | ZKSCAN16 | |
Cytomap | 9q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8TF39 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
158399 | ZNF483 | HCC1 | Human | Liver | HCC | 2.40e-14 | 1.84e+00 | 0.5336 |
158399 | ZNF483 | HCC2 | Human | Liver | HCC | 2.95e-21 | 1.93e+00 | 0.5341 |
158399 | ZNF483 | HCC5 | Human | Liver | HCC | 1.01e-16 | 1.59e+00 | 0.4932 |
158399 | ZNF483 | HTA12-15-2 | Human | Pancreas | PDAC | 4.45e-06 | 4.27e-01 | 0.2315 |
158399 | ZNF483 | HTA12-23-1 | Human | Pancreas | PDAC | 8.00e-12 | 8.15e-01 | 0.3405 |
158399 | ZNF483 | HTA12-25-1 | Human | Pancreas | PDAC | 1.68e-12 | 7.29e-01 | 0.313 |
158399 | ZNF483 | HTA12-26-1 | Human | Pancreas | PDAC | 5.15e-30 | 1.01e+00 | 0.3728 |
158399 | ZNF483 | HTA12-29-1 | Human | Pancreas | PDAC | 5.38e-40 | 7.37e-01 | 0.3722 |
158399 | ZNF483 | HTA12-9-3 | Human | Pancreas | PDAC | 8.76e-04 | 6.05e-01 | 0.2045 |
158399 | ZNF483 | male-WTA | Human | Thyroid | PTC | 3.45e-19 | 3.05e-01 | 0.1037 |
158399 | ZNF483 | PTC01 | Human | Thyroid | PTC | 8.32e-03 | 1.40e-01 | 0.1899 |
158399 | ZNF483 | PTC04 | Human | Thyroid | PTC | 9.63e-11 | 1.90e-01 | 0.1927 |
158399 | ZNF483 | PTC05 | Human | Thyroid | PTC | 1.97e-14 | 5.00e-01 | 0.2065 |
158399 | ZNF483 | PTC06 | Human | Thyroid | PTC | 3.78e-19 | 4.40e-01 | 0.2057 |
158399 | ZNF483 | PTC07 | Human | Thyroid | PTC | 4.08e-21 | 3.55e-01 | 0.2044 |
158399 | ZNF483 | ATC13 | Human | Thyroid | ATC | 1.29e-04 | 9.28e-02 | 0.34 |
158399 | ZNF483 | ATC5 | Human | Thyroid | ATC | 1.80e-05 | 9.94e-02 | 0.34 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF483 | NK | Esophagus | ADJ | BDNF-AS,COL13A1,TGFB3, etc. | 1.26e-01 | ![]() |
ZNF483 | NK | Esophagus | ESCC | BDNF-AS,COL13A1,TGFB3, etc. | 7.43e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF483 | SNV | Missense_Mutation | c.223G>A | p.Glu75Lys | p.E75K | Q8TF39 | protein_coding | deleterious(0) | benign(0.046) | TCGA-77-8136-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF483 | SNV | Missense_Mutation | novel | c.1895N>G | p.Glu632Gly | p.E632G | Q8TF39 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-77-8153-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF483 | SNV | Missense_Mutation | novel | c.1063N>A | p.Gly355Arg | p.G355R | Q8TF39 | protein_coding | tolerated(0.09) | benign(0.081) | TCGA-85-7699-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
ZNF483 | SNV | Missense_Mutation | novel | c.1817N>T | p.Pro606Leu | p.P606L | Q8TF39 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF483 | SNV | Missense_Mutation | c.1775N>T | p.Ser592Leu | p.S592L | Q8TF39 | protein_coding | deleterious(0) | possibly_damaging(0.476) | TCGA-CN-5374-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
ZNF483 | SNV | Missense_Mutation | novel | c.1345N>A | p.Gly449Ser | p.G449S | Q8TF39 | protein_coding | tolerated(1) | benign(0.005) | TCGA-CV-A6JO-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF483 | insertion | Nonsense_Mutation | novel | c.1385_1386insATAGGGGTTTTTCTCCTAGAAAGAG | p.Gly463Ter | p.G463* | Q8TF39 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD | ||
ZNF483 | SNV | Missense_Mutation | novel | c.1687A>T | p.Ser563Cys | p.S563C | Q8TF39 | protein_coding | deleterious(0.01) | possibly_damaging(0.825) | TCGA-YL-A8HM-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | casodex | PD |
ZNF483 | SNV | Missense_Mutation | c.1552A>G | p.Thr518Ala | p.T518A | Q8TF39 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF483 | SNV | Missense_Mutation | c.928N>G | p.Asn310Asp | p.N310D | Q8TF39 | protein_coding | tolerated(0.15) | benign(0.04) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
Page: 1 2 3 4 5 6 7 8 9 10 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |