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Gene: ZNF10 |
Gene summary for ZNF10 |
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Gene information | Species | Human | Gene symbol | ZNF10 | Gene ID | 7556 |
Gene name | zinc finger protein 10 | |
Gene Alias | KOX1 | |
Cytomap | 12q24.33 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P21506 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7556 | ZNF10 | LZE4T | Human | Esophagus | ESCC | 6.35e-07 | 2.44e-01 | 0.0811 |
7556 | ZNF10 | LZE7T | Human | Esophagus | ESCC | 3.99e-03 | 2.73e-01 | 0.0667 |
7556 | ZNF10 | LZE20T | Human | Esophagus | ESCC | 2.48e-02 | 1.30e-01 | 0.0662 |
7556 | ZNF10 | LZE21D1 | Human | Esophagus | HGIN | 2.59e-02 | 1.83e-01 | 0.0632 |
7556 | ZNF10 | LZE22T | Human | Esophagus | ESCC | 4.16e-04 | 2.06e-01 | 0.068 |
7556 | ZNF10 | LZE24T | Human | Esophagus | ESCC | 1.02e-12 | 2.53e-01 | 0.0596 |
7556 | ZNF10 | LZE21T | Human | Esophagus | ESCC | 4.65e-02 | 2.09e-01 | 0.0655 |
7556 | ZNF10 | P1T-E | Human | Esophagus | ESCC | 2.04e-08 | 4.02e-01 | 0.0875 |
7556 | ZNF10 | P2T-E | Human | Esophagus | ESCC | 1.10e-45 | 7.76e-01 | 0.1177 |
7556 | ZNF10 | P4T-E | Human | Esophagus | ESCC | 5.07e-19 | 5.04e-01 | 0.1323 |
7556 | ZNF10 | P5T-E | Human | Esophagus | ESCC | 1.95e-13 | 3.20e-01 | 0.1327 |
7556 | ZNF10 | P8T-E | Human | Esophagus | ESCC | 5.29e-14 | 2.44e-01 | 0.0889 |
7556 | ZNF10 | P10T-E | Human | Esophagus | ESCC | 2.12e-12 | 2.39e-01 | 0.116 |
7556 | ZNF10 | P11T-E | Human | Esophagus | ESCC | 1.22e-10 | 6.39e-01 | 0.1426 |
7556 | ZNF10 | P12T-E | Human | Esophagus | ESCC | 4.63e-21 | 4.06e-01 | 0.1122 |
7556 | ZNF10 | P15T-E | Human | Esophagus | ESCC | 2.44e-11 | 1.69e-01 | 0.1149 |
7556 | ZNF10 | P16T-E | Human | Esophagus | ESCC | 1.08e-24 | 4.41e-01 | 0.1153 |
7556 | ZNF10 | P17T-E | Human | Esophagus | ESCC | 1.73e-04 | 1.29e-01 | 0.1278 |
7556 | ZNF10 | P21T-E | Human | Esophagus | ESCC | 4.18e-10 | 2.27e-01 | 0.1617 |
7556 | ZNF10 | P22T-E | Human | Esophagus | ESCC | 2.15e-17 | 3.55e-01 | 0.1236 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:00434343 | Colorectum | FAP | response to peptide hormone | 100/2622 | 414/18723 | 1.74e-08 | 1.84e-06 | 100 |
GO:19016533 | Colorectum | FAP | cellular response to peptide | 89/2622 | 359/18723 | 2.93e-08 | 2.64e-06 | 89 |
GO:00713753 | Colorectum | FAP | cellular response to peptide hormone stimulus | 75/2622 | 290/18723 | 5.60e-08 | 4.29e-06 | 75 |
GO:00328683 | Colorectum | FAP | response to insulin | 68/2622 | 264/18723 | 2.71e-07 | 1.55e-05 | 68 |
GO:00328693 | Colorectum | FAP | cellular response to insulin stimulus | 54/2622 | 203/18723 | 1.54e-06 | 6.59e-05 | 54 |
GO:0008286 | Colorectum | FAP | insulin receptor signaling pathway | 28/2622 | 116/18723 | 2.37e-03 | 1.89e-02 | 28 |
GO:00434344 | Colorectum | CRC | response to peptide hormone | 76/2078 | 414/18723 | 6.67e-06 | 2.56e-04 | 76 |
GO:00328684 | Colorectum | CRC | response to insulin | 53/2078 | 264/18723 | 1.30e-05 | 4.17e-04 | 53 |
GO:00328694 | Colorectum | CRC | cellular response to insulin stimulus | 42/2078 | 203/18723 | 4.79e-05 | 1.12e-03 | 42 |
GO:00713754 | Colorectum | CRC | cellular response to peptide hormone stimulus | 55/2078 | 290/18723 | 4.82e-05 | 1.12e-03 | 55 |
GO:19016534 | Colorectum | CRC | cellular response to peptide | 64/2078 | 359/18723 | 8.54e-05 | 1.75e-03 | 64 |
GO:00082861 | Colorectum | CRC | insulin receptor signaling pathway | 23/2078 | 116/18723 | 4.02e-03 | 3.33e-02 | 23 |
GO:190165319 | Esophagus | ESCC | cellular response to peptide | 208/8552 | 359/18723 | 1.68e-06 | 2.01e-05 | 208 |
GO:0043434111 | Esophagus | ESCC | response to peptide hormone | 234/8552 | 414/18723 | 4.93e-06 | 5.21e-05 | 234 |
GO:003286918 | Esophagus | ESCC | cellular response to insulin stimulus | 124/8552 | 203/18723 | 6.63e-06 | 6.75e-05 | 124 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF10 | SNV | Missense_Mutation | novel | c.977N>T | p.Cys326Phe | p.C326F | P21506 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
ZNF10 | insertion | Frame_Shift_Ins | novel | c.1459_1460insTCTCTGGCTGT | p.Lys487IlefsTer51 | p.K487Ifs*51 | P21506 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
ZNF10 | insertion | Frame_Shift_Ins | novel | c.559_560insCTTCTTCT | p.Lys187ThrfsTer12 | p.K187Tfs*12 | P21506 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
ZNF10 | insertion | In_Frame_Ins | novel | c.978_979insTCCACATTCCTTACATTCATA | p.Cys326_Gly327insSerThrPheLeuThrPheIle | p.C326_G327insSTFLTFI | P21506 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
ZNF10 | insertion | Frame_Shift_Ins | novel | c.978_979insTCCACATTCCTTACATTCATAG | p.Gly327SerfsTer33 | p.G327Sfs*33 | P21506 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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