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Gene: ZC3H6 |
Gene summary for ZC3H6 |
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Gene information | Species | Human | Gene symbol | ZC3H6 | Gene ID | 376940 |
Gene name | zinc finger CCCH-type containing 6 | |
Gene Alias | ZC3HDC6 | |
Cytomap | 2q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P61129 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
376940 | ZC3H6 | LZE20T | Human | Esophagus | ESCC | 1.51e-05 | 1.63e-01 | 0.0662 |
376940 | ZC3H6 | LZE22T | Human | Esophagus | ESCC | 3.36e-02 | 2.35e-01 | 0.068 |
376940 | ZC3H6 | LZE24T | Human | Esophagus | ESCC | 1.62e-03 | 2.01e-01 | 0.0596 |
376940 | ZC3H6 | P1T-E | Human | Esophagus | ESCC | 7.94e-07 | 3.20e-01 | 0.0875 |
376940 | ZC3H6 | P2T-E | Human | Esophagus | ESCC | 4.54e-23 | 3.77e-01 | 0.1177 |
376940 | ZC3H6 | P4T-E | Human | Esophagus | ESCC | 1.27e-09 | 3.12e-01 | 0.1323 |
376940 | ZC3H6 | P8T-E | Human | Esophagus | ESCC | 2.22e-07 | 1.10e-01 | 0.0889 |
376940 | ZC3H6 | P9T-E | Human | Esophagus | ESCC | 1.92e-05 | 1.76e-01 | 0.1131 |
376940 | ZC3H6 | P10T-E | Human | Esophagus | ESCC | 2.56e-22 | 4.56e-01 | 0.116 |
376940 | ZC3H6 | P12T-E | Human | Esophagus | ESCC | 4.64e-11 | 2.69e-01 | 0.1122 |
376940 | ZC3H6 | P15T-E | Human | Esophagus | ESCC | 8.58e-16 | 3.41e-01 | 0.1149 |
376940 | ZC3H6 | P16T-E | Human | Esophagus | ESCC | 1.24e-22 | 3.91e-01 | 0.1153 |
376940 | ZC3H6 | P17T-E | Human | Esophagus | ESCC | 1.03e-02 | 2.39e-01 | 0.1278 |
376940 | ZC3H6 | P20T-E | Human | Esophagus | ESCC | 2.49e-05 | 1.75e-01 | 0.1124 |
376940 | ZC3H6 | P21T-E | Human | Esophagus | ESCC | 3.60e-12 | 3.32e-01 | 0.1617 |
376940 | ZC3H6 | P22T-E | Human | Esophagus | ESCC | 2.86e-06 | 1.24e-01 | 0.1236 |
376940 | ZC3H6 | P23T-E | Human | Esophagus | ESCC | 2.85e-12 | 3.74e-01 | 0.108 |
376940 | ZC3H6 | P24T-E | Human | Esophagus | ESCC | 2.13e-11 | 2.64e-01 | 0.1287 |
376940 | ZC3H6 | P26T-E | Human | Esophagus | ESCC | 9.15e-20 | 5.03e-01 | 0.1276 |
376940 | ZC3H6 | P27T-E | Human | Esophagus | ESCC | 1.19e-10 | 2.21e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZC3H6 | SNV | Missense_Mutation | novel | c.3479C>A | p.Thr1160Asn | p.T1160N | P61129 | protein_coding | tolerated(0.48) | benign(0.029) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
ZC3H6 | SNV | Missense_Mutation | novel | c.1198N>A | p.Pro400Thr | p.P400T | P61129 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-H5-A2HR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZC3H6 | SNV | Missense_Mutation | rs557004552 | c.2464N>A | p.Asp822Asn | p.D822N | P61129 | protein_coding | tolerated(0.07) | possibly_damaging(0.632) | TCGA-SJ-A6ZI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZC3H6 | deletion | In_Frame_Del | c.664_678delNNNNNNNNNNNNNNN | p.Pro222_Lys226del | p.P222_K226del | P61129 | protein_coding | TCGA-A5-A0G3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |||
ZC3H6 | deletion | Frame_Shift_Del | c.582delN | p.Lys196AsnfsTer4 | p.K196Nfs*4 | P61129 | protein_coding | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ZC3H6 | deletion | Frame_Shift_Del | novel | c.156delA | p.Lys52AsnfsTer70 | p.K52Nfs*70 | P61129 | protein_coding | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZC3H6 | insertion | Frame_Shift_Ins | novel | c.149_150insA | p.His53ThrfsTer2 | p.H53Tfs*2 | P61129 | protein_coding | TCGA-AP-A1DO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZC3H6 | deletion | Frame_Shift_Del | c.588delA | p.Lys196AsnfsTer4 | p.K196Nfs*4 | P61129 | protein_coding | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
ZC3H6 | insertion | Nonsense_Mutation | novel | c.1384_1385insAACCAAGATTTGGAAGCAACCTAAGTGTCCACCACCAGGACCACAAT | p.Phe462Ter | p.F462* | P61129 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD | ||
ZC3H6 | insertion | Frame_Shift_Ins | rs768934713 | c.3222_3223insA | p.Ser1077LysfsTer7 | p.S1077Kfs*7 | P61129 | protein_coding | TCGA-DF-A2KZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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