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Gene: XPR1 |
Gene summary for XPR1 |
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Gene information | Species | Human | Gene symbol | XPR1 | Gene ID | 9213 |
Gene name | xenotropic and polytropic retrovirus receptor 1 | |
Gene Alias | IBGC6 | |
Cytomap | 1q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9UBH6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9213 | XPR1 | CCI_2 | Human | Cervix | CC | 2.22e-22 | 3.07e+00 | 0.5249 |
9213 | XPR1 | CCI_3 | Human | Cervix | CC | 1.63e-17 | 1.27e+00 | 0.516 |
9213 | XPR1 | sample1 | Human | Cervix | CC | 1.25e-03 | 4.15e-01 | 0.0959 |
9213 | XPR1 | T1 | Human | Cervix | CC | 5.02e-04 | 3.37e-01 | 0.0918 |
9213 | XPR1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.00e-07 | -4.09e-01 | 0.0155 |
9213 | XPR1 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.66e-04 | -2.69e-01 | -0.1464 |
9213 | XPR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.07e-03 | -2.64e-01 | -0.1001 |
9213 | XPR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.27e-03 | -3.72e-01 | 0.096 |
9213 | XPR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.33e-09 | -4.32e-01 | 0.0674 |
9213 | XPR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.99e-08 | -3.14e-01 | 0.294 |
9213 | XPR1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.54e-03 | -3.04e-01 | 0.3859 |
9213 | XPR1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.32e-02 | -4.86e-01 | 0.2585 |
9213 | XPR1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.28e-15 | -4.94e-01 | 0.3005 |
9213 | XPR1 | F007 | Human | Colorectum | FAP | 1.65e-03 | -3.28e-01 | 0.1176 |
9213 | XPR1 | A001-C-207 | Human | Colorectum | FAP | 1.54e-03 | -2.53e-01 | 0.1278 |
9213 | XPR1 | A015-C-203 | Human | Colorectum | FAP | 2.48e-22 | -4.02e-01 | -0.1294 |
9213 | XPR1 | A015-C-204 | Human | Colorectum | FAP | 4.86e-05 | -3.40e-01 | -0.0228 |
9213 | XPR1 | A014-C-040 | Human | Colorectum | FAP | 8.52e-03 | -4.11e-01 | -0.1184 |
9213 | XPR1 | A002-C-201 | Human | Colorectum | FAP | 7.32e-14 | -3.60e-01 | 0.0324 |
9213 | XPR1 | A002-C-203 | Human | Colorectum | FAP | 8.64e-06 | -2.62e-01 | 0.2786 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603210 | Cervix | CC | viral process | 109/2311 | 415/18723 | 5.40e-15 | 6.46e-12 | 109 |
GO:001905810 | Cervix | CC | viral life cycle | 87/2311 | 317/18723 | 2.20e-13 | 1.20e-10 | 87 |
GO:005212610 | Cervix | CC | movement in host environment | 52/2311 | 175/18723 | 7.03e-10 | 8.76e-08 | 52 |
GO:004440910 | Cervix | CC | entry into host | 47/2311 | 151/18723 | 8.45e-10 | 1.03e-07 | 47 |
GO:005170110 | Cervix | CC | biological process involved in interaction with host | 57/2311 | 203/18723 | 1.18e-09 | 1.41e-07 | 57 |
GO:007149610 | Cervix | CC | cellular response to external stimulus | 78/2311 | 320/18723 | 1.82e-09 | 1.98e-07 | 78 |
GO:004671810 | Cervix | CC | viral entry into host cell | 44/2311 | 144/18723 | 5.47e-09 | 5.03e-07 | 44 |
GO:004440310 | Cervix | CC | biological process involved in symbiotic interaction | 71/2311 | 290/18723 | 7.94e-09 | 6.98e-07 | 71 |
GO:00316689 | Cervix | CC | cellular response to extracellular stimulus | 59/2311 | 246/18723 | 3.03e-07 | 1.24e-05 | 59 |
GO:003166710 | Cervix | CC | response to nutrient levels | 92/2311 | 474/18723 | 5.80e-06 | 1.42e-04 | 92 |
GO:00092678 | Cervix | CC | cellular response to starvation | 39/2311 | 156/18723 | 1.04e-05 | 2.32e-04 | 39 |
GO:00425948 | Cervix | CC | response to starvation | 46/2311 | 197/18723 | 1.24e-05 | 2.59e-04 | 46 |
GO:00316698 | Cervix | CC | cellular response to nutrient levels | 49/2311 | 215/18723 | 1.32e-05 | 2.68e-04 | 49 |
GO:00096158 | Cervix | CC | response to virus | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0044403 | Colorectum | AD | biological process involved in symbiotic interaction | 99/3918 | 290/18723 | 1.02e-07 | 4.93e-06 | 99 |
GO:0051701 | Colorectum | AD | biological process involved in interaction with host | 73/3918 | 203/18723 | 5.08e-07 | 1.88e-05 | 73 |
GO:0052126 | Colorectum | AD | movement in host environment | 63/3918 | 175/18723 | 2.85e-06 | 8.11e-05 | 63 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
XPR1 | SNV | Missense_Mutation | c.988N>C | p.Ser330Arg | p.S330R | Q9UBH6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | |
XPR1 | SNV | Missense_Mutation | c.1064N>A | p.Met355Lys | p.M355K | Q9UBH6 | protein_coding | deleterious(0) | possibly_damaging(0.633) | TCGA-BR-A4J7-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
XPR1 | SNV | Missense_Mutation | c.1879N>T | p.Arg627Trp | p.R627W | Q9UBH6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
XPR1 | SNV | Missense_Mutation | novel | c.1991N>G | p.Asn664Ser | p.N664S | Q9UBH6 | protein_coding | tolerated(1) | benign(0) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
XPR1 | SNV | Missense_Mutation | c.1631A>G | p.Asn544Ser | p.N544S | Q9UBH6 | protein_coding | deleterious(0.02) | possibly_damaging(0.733) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR | |
XPR1 | SNV | Missense_Mutation | c.1843N>A | p.Glu615Lys | p.E615K | Q9UBH6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EM-A3FR-01 | Thyroid | thyroid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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