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Gene: TRPC4AP |
Gene summary for TRPC4AP |
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Gene information | Species | Human | Gene symbol | TRPC4AP | Gene ID | 26133 |
Gene name | transient receptor potential cation channel subfamily C member 4 associated protein | |
Gene Alias | C20orf188 | |
Cytomap | 20q11.22 | |
Gene Type | protein-coding | GO ID | GO:0001942 | UniProtAcc | Q8TEL6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26133 | TRPC4AP | CCI_1 | Human | Cervix | CC | 3.64e-03 | 5.37e-01 | 0.528 |
26133 | TRPC4AP | CCI_2 | Human | Cervix | CC | 1.47e-07 | 7.72e-01 | 0.5249 |
26133 | TRPC4AP | CCI_3 | Human | Cervix | CC | 3.98e-03 | 3.84e-01 | 0.516 |
26133 | TRPC4AP | LZE4T | Human | Esophagus | ESCC | 7.56e-22 | 3.94e-01 | 0.0811 |
26133 | TRPC4AP | LZE5T | Human | Esophagus | ESCC | 1.18e-02 | 3.52e-01 | 0.0514 |
26133 | TRPC4AP | LZE7T | Human | Esophagus | ESCC | 5.64e-07 | 5.03e-01 | 0.0667 |
26133 | TRPC4AP | LZE20T | Human | Esophagus | ESCC | 3.98e-08 | 2.13e-01 | 0.0662 |
26133 | TRPC4AP | LZE21D1 | Human | Esophagus | HGIN | 1.35e-02 | 2.08e-01 | 0.0632 |
26133 | TRPC4AP | LZE22D1 | Human | Esophagus | HGIN | 1.51e-03 | 9.33e-02 | 0.0595 |
26133 | TRPC4AP | LZE22T | Human | Esophagus | ESCC | 2.02e-04 | 2.74e-01 | 0.068 |
26133 | TRPC4AP | LZE24D1 | Human | Esophagus | HGIN | 2.15e-02 | 3.97e-01 | 0.054 |
26133 | TRPC4AP | LZE24T | Human | Esophagus | ESCC | 4.28e-23 | 7.84e-01 | 0.0596 |
26133 | TRPC4AP | LZE21T | Human | Esophagus | ESCC | 1.10e-05 | 2.11e-01 | 0.0655 |
26133 | TRPC4AP | P1T-E | Human | Esophagus | ESCC | 1.49e-10 | 6.09e-01 | 0.0875 |
26133 | TRPC4AP | P2T-E | Human | Esophagus | ESCC | 1.01e-32 | 4.88e-01 | 0.1177 |
26133 | TRPC4AP | P4T-E | Human | Esophagus | ESCC | 1.28e-21 | 4.30e-01 | 0.1323 |
26133 | TRPC4AP | P5T-E | Human | Esophagus | ESCC | 1.37e-16 | 2.54e-01 | 0.1327 |
26133 | TRPC4AP | P8T-E | Human | Esophagus | ESCC | 8.38e-40 | 6.45e-01 | 0.0889 |
26133 | TRPC4AP | P9T-E | Human | Esophagus | ESCC | 4.65e-15 | 3.41e-01 | 0.1131 |
26133 | TRPC4AP | P10T-E | Human | Esophagus | ESCC | 3.35e-32 | 5.78e-01 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
GO:00435884 | Cervix | CC | skin development | 71/2311 | 263/18723 | 8.04e-11 | 1.46e-08 | 71 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:001049826 | Esophagus | HGIN | proteasomal protein catabolic process | 139/2587 | 490/18723 | 1.20e-17 | 3.41e-15 | 139 |
GO:004316126 | Esophagus | HGIN | proteasome-mediated ubiquitin-dependent protein catabolic process | 114/2587 | 412/18723 | 7.00e-14 | 1.20e-11 | 114 |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:00435888 | Esophagus | ESCC | skin development | 163/8552 | 263/18723 | 6.48e-08 | 1.14e-06 | 163 |
GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
GO:00224043 | Esophagus | ESCC | molting cycle process | 53/8552 | 84/18723 | 9.62e-04 | 4.88e-03 | 53 |
GO:00224053 | Esophagus | ESCC | hair cycle process | 53/8552 | 84/18723 | 9.62e-04 | 4.88e-03 | 53 |
GO:0001942 | Esophagus | ESCC | hair follicle development | 51/8552 | 81/18723 | 1.27e-03 | 6.14e-03 | 51 |
GO:0098773 | Esophagus | ESCC | skin epidermis development | 53/8552 | 85/18723 | 1.43e-03 | 6.77e-03 | 53 |
GO:00423033 | Esophagus | ESCC | molting cycle | 64/8552 | 107/18723 | 2.24e-03 | 9.85e-03 | 64 |
GO:00426333 | Esophagus | ESCC | hair cycle | 64/8552 | 107/18723 | 2.24e-03 | 9.85e-03 | 64 |
GO:00488201 | Esophagus | ESCC | hair follicle maturation | 11/8552 | 13/18723 | 4.76e-03 | 1.85e-02 | 11 |
GO:00431617 | Liver | NAFLD | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/1882 | 412/18723 | 3.00e-13 | 1.75e-10 | 91 |
GO:00104987 | Liver | NAFLD | proteasomal protein catabolic process | 101/1882 | 490/18723 | 1.35e-12 | 6.09e-10 | 101 |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRPC4AP | SNV | Missense_Mutation | c.304N>A | p.Ser102Thr | p.S102T | Q8TEL6 | protein_coding | tolerated(0.47) | probably_damaging(0.931) | TCGA-CD-8529-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | epirubicin | CR | |
TRPC4AP | SNV | Missense_Mutation | novel | c.533N>G | p.Glu178Gly | p.E178G | Q8TEL6 | protein_coding | tolerated(0.12) | benign(0.255) | TCGA-RD-A7C1-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TRPC4AP | SNV | Missense_Mutation | novel | c.455N>T | p.Arg152Leu | p.R152L | Q8TEL6 | protein_coding | tolerated(0.14) | benign(0) | TCGA-DJ-A2QB-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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