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Gene: TRIM33 |
Gene summary for TRIM33 |
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Gene information | Species | Human | Gene symbol | TRIM33 | Gene ID | 51592 |
Gene name | tripartite motif containing 33 | |
Gene Alias | ECTO | |
Cytomap | 1p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B3KN30 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51592 | TRIM33 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.76e-09 | -4.08e-01 | 0.0155 |
51592 | TRIM33 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.57e-02 | -3.47e-01 | 0.096 |
51592 | TRIM33 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.90e-05 | -2.68e-01 | 0.0674 |
51592 | TRIM33 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.87e-05 | -2.99e-01 | 0.3005 |
51592 | TRIM33 | A001-C-207 | Human | Colorectum | FAP | 1.95e-05 | -2.68e-01 | 0.1278 |
51592 | TRIM33 | A015-C-203 | Human | Colorectum | FAP | 4.38e-30 | -3.16e-01 | -0.1294 |
51592 | TRIM33 | A015-C-204 | Human | Colorectum | FAP | 6.80e-12 | -3.84e-01 | -0.0228 |
51592 | TRIM33 | A014-C-040 | Human | Colorectum | FAP | 2.62e-07 | -4.83e-01 | -0.1184 |
51592 | TRIM33 | A002-C-201 | Human | Colorectum | FAP | 2.25e-17 | -3.29e-01 | 0.0324 |
51592 | TRIM33 | A002-C-203 | Human | Colorectum | FAP | 2.07e-06 | -2.61e-01 | 0.2786 |
51592 | TRIM33 | A001-C-119 | Human | Colorectum | FAP | 1.23e-12 | -5.37e-01 | -0.1557 |
51592 | TRIM33 | A001-C-108 | Human | Colorectum | FAP | 1.01e-18 | -2.56e-01 | -0.0272 |
51592 | TRIM33 | A002-C-205 | Human | Colorectum | FAP | 1.16e-24 | -3.32e-01 | -0.1236 |
51592 | TRIM33 | A001-C-104 | Human | Colorectum | FAP | 1.42e-06 | -2.88e-01 | 0.0184 |
51592 | TRIM33 | A015-C-005 | Human | Colorectum | FAP | 4.05e-05 | -2.23e-01 | -0.0336 |
51592 | TRIM33 | A015-C-006 | Human | Colorectum | FAP | 4.37e-16 | -3.54e-01 | -0.0994 |
51592 | TRIM33 | A015-C-106 | Human | Colorectum | FAP | 2.03e-15 | -1.88e-01 | -0.0511 |
51592 | TRIM33 | A002-C-114 | Human | Colorectum | FAP | 3.15e-21 | -3.97e-01 | -0.1561 |
51592 | TRIM33 | A015-C-104 | Human | Colorectum | FAP | 1.17e-32 | -4.17e-01 | -0.1899 |
51592 | TRIM33 | A001-C-014 | Human | Colorectum | FAP | 1.59e-14 | -3.21e-01 | 0.0135 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007178 | Colorectum | AD | transmembrane receptor protein serine/threonine kinase signaling pathway | 99/3918 | 355/18723 | 9.92e-04 | 9.28e-03 | 99 |
GO:0071559 | Colorectum | AD | response to transforming growth factor beta | 74/3918 | 256/18723 | 1.45e-03 | 1.23e-02 | 74 |
GO:0071560 | Colorectum | AD | cellular response to transforming growth factor beta stimulus | 72/3918 | 250/18723 | 1.85e-03 | 1.52e-02 | 72 |
GO:0007179 | Colorectum | AD | transforming growth factor beta receptor signaling pathway | 59/3918 | 198/18723 | 1.94e-03 | 1.58e-02 | 59 |
GO:00071781 | Colorectum | MSS | transmembrane receptor protein serine/threonine kinase signaling pathway | 86/3467 | 355/18723 | 4.04e-03 | 2.95e-02 | 86 |
GO:00715591 | Colorectum | FAP | response to transforming growth factor beta | 63/2622 | 256/18723 | 3.82e-06 | 1.32e-04 | 63 |
GO:00071782 | Colorectum | FAP | transmembrane receptor protein serine/threonine kinase signaling pathway | 81/2622 | 355/18723 | 4.28e-06 | 1.46e-04 | 81 |
GO:00715601 | Colorectum | FAP | cellular response to transforming growth factor beta stimulus | 61/2622 | 250/18723 | 7.22e-06 | 2.19e-04 | 61 |
GO:00071791 | Colorectum | FAP | transforming growth factor beta receptor signaling pathway | 50/2622 | 198/18723 | 1.75e-05 | 4.44e-04 | 50 |
GO:0017015 | Colorectum | FAP | regulation of transforming growth factor beta receptor signaling pathway | 31/2622 | 128/18723 | 1.35e-03 | 1.24e-02 | 31 |
GO:1903844 | Colorectum | FAP | regulation of cellular response to transforming growth factor beta stimulus | 31/2622 | 131/18723 | 2.01e-03 | 1.67e-02 | 31 |
GO:0071772 | Colorectum | FAP | response to BMP | 37/2622 | 165/18723 | 2.20e-03 | 1.80e-02 | 37 |
GO:0071773 | Colorectum | FAP | cellular response to BMP stimulus | 37/2622 | 165/18723 | 2.20e-03 | 1.80e-02 | 37 |
GO:0090092 | Colorectum | FAP | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 52/2622 | 256/18723 | 3.33e-03 | 2.44e-02 | 52 |
GO:0030509 | Colorectum | FAP | BMP signaling pathway | 34/2622 | 152/18723 | 3.38e-03 | 2.47e-02 | 34 |
GO:00071783 | Colorectum | CRC | transmembrane receptor protein serine/threonine kinase signaling pathway | 66/2078 | 355/18723 | 1.74e-05 | 5.28e-04 | 66 |
GO:00715592 | Colorectum | CRC | response to transforming growth factor beta | 51/2078 | 256/18723 | 2.33e-05 | 6.65e-04 | 51 |
GO:00715602 | Colorectum | CRC | cellular response to transforming growth factor beta stimulus | 49/2078 | 250/18723 | 5.17e-05 | 1.19e-03 | 49 |
GO:00071792 | Colorectum | CRC | transforming growth factor beta receptor signaling pathway | 39/2078 | 198/18723 | 2.58e-04 | 4.19e-03 | 39 |
GO:00305091 | Colorectum | CRC | BMP signaling pathway | 31/2078 | 152/18723 | 5.73e-04 | 7.89e-03 | 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM33 | SNV | Missense_Mutation | novel | c.2311N>T | p.Asp771Tyr | p.D771Y | Q9UPN9 | protein_coding | deleterious(0) | possibly_damaging(0.548) | TCGA-NC-A5HI-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
TRIM33 | insertion | Frame_Shift_Ins | novel | c.1589_1590insTGTAGTAACACGATACTTACCTGTT | p.Gln530HisfsTer34 | p.Q530Hfs*34 | Q9UPN9 | protein_coding | TCGA-22-4591-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemzar | PD | ||
TRIM33 | SNV | Missense_Mutation | novel | c.1955N>T | p.Asn652Ile | p.N652I | Q9UPN9 | protein_coding | tolerated(0.44) | benign(0.091) | TCGA-CV-5435-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
TRIM33 | SNV | Missense_Mutation | c.539N>T | p.Arg180Leu | p.R180L | Q9UPN9 | protein_coding | deleterious(0) | possibly_damaging(0.891) | TCGA-CV-7238-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRIM33 | SNV | Missense_Mutation | novel | c.1462N>T | p.Pro488Ser | p.P488S | Q9UPN9 | protein_coding | deleterious(0.01) | benign(0.168) | TCGA-CV-A45O-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRIM33 | SNV | Missense_Mutation | novel | c.1756N>G | p.Gln586Glu | p.Q586E | Q9UPN9 | protein_coding | tolerated(0.37) | benign(0.136) | TCGA-T2-A6X2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TRIM33 | SNV | Missense_Mutation | c.3085N>T | p.Arg1029Cys | p.R1029C | Q9UPN9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-HC-7077-01 | Prostate | prostate adenocarcinoma | Male | <65 | 6 | Unknown | Unknown | SD | |
TRIM33 | SNV | Missense_Mutation | novel | c.2672C>T | p.Ala891Val | p.A891V | Q9UPN9 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
TRIM33 | SNV | Missense_Mutation | novel | c.713N>A | p.Cys238Tyr | p.C238Y | Q9UPN9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-ZG-A9N3-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | bicalutamide | SD |
TRIM33 | SNV | Missense_Mutation | c.1931N>A | p.Ser644Asn | p.S644N | Q9UPN9 | protein_coding | deleterious(0.02) | probably_damaging(0.968) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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