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Gene: TNS2 |
Gene summary for TNS2 |
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Gene information | Species | Human | Gene symbol | TNS2 | Gene ID | 23371 |
Gene name | tensin 2 | |
Gene Alias | C1-TEN | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0001655 | UniProtAcc | Q63HR2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23371 | TNS2 | male-WTA | Human | Thyroid | PTC | 4.03e-08 | 1.12e-01 | 0.1037 |
23371 | TNS2 | PTC01 | Human | Thyroid | PTC | 5.84e-08 | 1.30e-01 | 0.1899 |
23371 | TNS2 | PTC03 | Human | Thyroid | PTC | 6.20e-04 | 2.84e-01 | 0.1784 |
23371 | TNS2 | PTC04 | Human | Thyroid | PTC | 1.00e-14 | 3.35e-01 | 0.1927 |
23371 | TNS2 | PTC05 | Human | Thyroid | PTC | 5.30e-10 | 3.37e-01 | 0.2065 |
23371 | TNS2 | PTC06 | Human | Thyroid | PTC | 4.88e-16 | 3.51e-01 | 0.2057 |
23371 | TNS2 | PTC07 | Human | Thyroid | PTC | 5.31e-16 | 3.48e-01 | 0.2044 |
23371 | TNS2 | ATC11 | Human | Thyroid | ATC | 1.05e-07 | 5.28e-01 | 0.3386 |
23371 | TNS2 | ATC12 | Human | Thyroid | ATC | 2.19e-28 | 6.39e-01 | 0.34 |
23371 | TNS2 | ATC13 | Human | Thyroid | ATC | 4.22e-44 | 8.16e-01 | 0.34 |
23371 | TNS2 | ATC2 | Human | Thyroid | ATC | 1.68e-10 | 6.19e-01 | 0.34 |
23371 | TNS2 | ATC3 | Human | Thyroid | ATC | 2.50e-03 | 2.54e-01 | 0.338 |
23371 | TNS2 | ATC4 | Human | Thyroid | ATC | 4.26e-40 | 7.79e-01 | 0.34 |
23371 | TNS2 | ATC5 | Human | Thyroid | ATC | 6.96e-46 | 8.79e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1901653111 | Thyroid | PTC | cellular response to peptide | 169/5968 | 359/18723 | 9.81e-10 | 2.89e-08 | 169 |
GO:0043434113 | Thyroid | PTC | response to peptide hormone | 188/5968 | 414/18723 | 4.13e-09 | 1.09e-07 | 188 |
GO:0071375110 | Thyroid | PTC | cellular response to peptide hormone stimulus | 136/5968 | 290/18723 | 5.49e-08 | 1.17e-06 | 136 |
GO:0032869111 | Thyroid | PTC | cellular response to insulin stimulus | 100/5968 | 203/18723 | 1.70e-07 | 3.19e-06 | 100 |
GO:0032868111 | Thyroid | PTC | response to insulin | 124/5968 | 264/18723 | 1.87e-07 | 3.47e-06 | 124 |
GO:000182215 | Thyroid | PTC | kidney development | 133/5968 | 293/18723 | 7.57e-07 | 1.18e-05 | 133 |
GO:000165517 | Thyroid | PTC | urogenital system development | 149/5968 | 338/18723 | 1.41e-06 | 2.01e-05 | 149 |
GO:007200114 | Thyroid | PTC | renal system development | 135/5968 | 302/18723 | 1.76e-06 | 2.43e-05 | 135 |
GO:001631116 | Thyroid | PTC | dephosphorylation | 174/5968 | 417/18723 | 1.20e-05 | 1.31e-04 | 174 |
GO:000647020 | Thyroid | PTC | protein dephosphorylation | 123/5968 | 281/18723 | 1.69e-05 | 1.77e-04 | 123 |
GO:000828617 | Thyroid | PTC | insulin receptor signaling pathway | 58/5968 | 116/18723 | 3.59e-05 | 3.36e-04 | 58 |
GO:00352648 | Thyroid | PTC | multicellular organism growth | 56/5968 | 132/18723 | 6.79e-03 | 2.92e-02 | 56 |
GO:19000764 | Thyroid | PTC | regulation of cellular response to insulin stimulus | 30/5968 | 64/18723 | 8.53e-03 | 3.58e-02 | 30 |
GO:000182222 | Thyroid | ATC | kidney development | 146/6293 | 293/18723 | 5.81e-09 | 1.28e-07 | 146 |
GO:190165325 | Thyroid | ATC | cellular response to peptide | 173/6293 | 359/18723 | 5.87e-09 | 1.28e-07 | 173 |
GO:000165522 | Thyroid | ATC | urogenital system development | 164/6293 | 338/18723 | 7.92e-09 | 1.70e-07 | 164 |
GO:007200122 | Thyroid | ATC | renal system development | 149/6293 | 302/18723 | 9.48e-09 | 1.99e-07 | 149 |
GO:004343428 | Thyroid | ATC | response to peptide hormone | 192/6293 | 414/18723 | 3.63e-08 | 6.70e-07 | 192 |
GO:007137524 | Thyroid | ATC | cellular response to peptide hormone stimulus | 138/6293 | 290/18723 | 4.90e-07 | 7.05e-06 | 138 |
GO:003286824 | Thyroid | ATC | response to insulin | 126/6293 | 264/18723 | 1.24e-06 | 1.59e-05 | 126 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNS2 | SNV | Missense_Mutation | rs781472180 | c.2162N>A | p.Arg721Lys | p.R721K | Q63HR2 | protein_coding | deleterious(0.03) | probably_damaging(0.969) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNS2 | SNV | Missense_Mutation | novel | c.2672N>T | p.Arg891Met | p.R891M | Q63HR2 | protein_coding | deleterious(0) | possibly_damaging(0.789) | TCGA-CX-7219-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TNS2 | SNV | Missense_Mutation | novel | c.785C>T | p.Ser262Phe | p.S262F | Q63HR2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-UF-A7JV-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TNS2 | deletion | Frame_Shift_Del | c.1514delC | p.Pro505ArgfsTer25 | p.P505Rfs*25 | Q63HR2 | protein_coding | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
TNS2 | SNV | Missense_Mutation | novel | c.1475C>A | p.Pro492His | p.P492H | Q63HR2 | protein_coding | deleterious(0.02) | probably_damaging(0.975) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
TNS2 | SNV | Missense_Mutation | novel | c.25N>T | p.Gly9Trp | p.G9W | Q63HR2 | protein_coding | deleterious_low_confidence(0.05) | possibly_damaging(0.82) | TCGA-YL-A8SB-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | casodex | PD |
TNS2 | deletion | Frame_Shift_Del | novel | c.2411_2432delNNNNNNNNNNNNNNNNNNNNNN | p.Ala804AspfsTer44 | p.A804Dfs*44 | Q63HR2 | protein_coding | TCGA-G9-6356-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | ||
TNS2 | SNV | Missense_Mutation | rs758034845 | c.4007N>T | p.Thr1336Met | p.T1336M | Q63HR2 | protein_coding | deleterious(0.01) | benign(0.122) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNS2 | SNV | Missense_Mutation | rs373363715 | c.4135N>A | p.Val1379Met | p.V1379M | Q63HR2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-8297-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | SD |
TNS2 | SNV | Missense_Mutation | rs372122149 | c.589C>T | p.Arg197Cys | p.R197C | Q63HR2 | protein_coding | deleterious(0) | possibly_damaging(0.882) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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