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Gene: SYTL2 |
Gene summary for SYTL2 |
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Gene information | Species | Human | Gene symbol | SYTL2 | Gene ID | 54843 |
Gene name | synaptotagmin like 2 | |
Gene Alias | CHR11SYT | |
Cytomap | 11q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9HCH5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54843 | SYTL2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.02e-15 | -5.75e-01 | 0.0155 |
54843 | SYTL2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.83e-06 | -8.55e-01 | 0.0216 |
54843 | SYTL2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.15e-15 | 1.17e+00 | -0.1088 |
54843 | SYTL2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.56e-23 | 1.11e+00 | -0.1954 |
54843 | SYTL2 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.39e-13 | 1.65e+00 | -0.2602 |
54843 | SYTL2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.23e-10 | 1.13e+00 | -0.2196 |
54843 | SYTL2 | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.22e-02 | -7.47e-01 | -0.00410000000000005 |
54843 | SYTL2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.12e-06 | -4.40e-01 | 0.096 |
54843 | SYTL2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.82e-04 | -5.75e-01 | 0.0528 |
54843 | SYTL2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.78e-04 | -5.87e-01 | 0.0131 |
54843 | SYTL2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.29e-04 | -3.90e-01 | 0.0674 |
54843 | SYTL2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.78e-07 | -4.25e-01 | 0.294 |
54843 | SYTL2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.62e-10 | -4.97e-01 | 0.3859 |
54843 | SYTL2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.64e-09 | -6.67e-01 | 0.2585 |
54843 | SYTL2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.49e-30 | -7.52e-01 | 0.3005 |
54843 | SYTL2 | F007 | Human | Colorectum | FAP | 9.97e-05 | 2.80e-01 | 0.1176 |
54843 | SYTL2 | A002-C-010 | Human | Colorectum | FAP | 2.72e-03 | 2.12e-01 | 0.242 |
54843 | SYTL2 | A001-C-207 | Human | Colorectum | FAP | 3.09e-07 | 3.28e-01 | 0.1278 |
54843 | SYTL2 | A015-C-203 | Human | Colorectum | FAP | 2.29e-29 | -7.05e-02 | -0.1294 |
54843 | SYTL2 | A015-C-204 | Human | Colorectum | FAP | 7.25e-07 | 1.08e-02 | -0.0228 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022406 | Colorectum | AD | membrane docking | 31/3918 | 86/18723 | 8.67e-04 | 8.45e-03 | 31 |
GO:0140056 | Colorectum | AD | organelle localization by membrane tethering | 28/3918 | 77/18723 | 1.29e-03 | 1.14e-02 | 28 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:00224061 | Colorectum | SER | membrane docking | 25/2897 | 86/18723 | 9.88e-04 | 1.17e-02 | 25 |
GO:00068871 | Colorectum | SER | exocytosis | 75/2897 | 352/18723 | 2.05e-03 | 2.03e-02 | 75 |
GO:01400561 | Colorectum | SER | organelle localization by membrane tethering | 22/2897 | 77/18723 | 2.46e-03 | 2.32e-02 | 22 |
GO:00224062 | Colorectum | MSS | membrane docking | 28/3467 | 86/18723 | 1.27e-03 | 1.21e-02 | 28 |
GO:01400562 | Colorectum | MSS | organelle localization by membrane tethering | 25/3467 | 77/18723 | 2.34e-03 | 1.91e-02 | 25 |
GO:00224063 | Colorectum | FAP | membrane docking | 22/2622 | 86/18723 | 3.11e-03 | 2.33e-02 | 22 |
GO:01400563 | Colorectum | FAP | organelle localization by membrane tethering | 19/2622 | 77/18723 | 8.67e-03 | 4.98e-02 | 19 |
GO:00224064 | Colorectum | CRC | membrane docking | 20/2078 | 86/18723 | 9.78e-04 | 1.17e-02 | 20 |
GO:01400564 | Colorectum | CRC | organelle localization by membrane tethering | 17/2078 | 77/18723 | 4.05e-03 | 3.35e-02 | 17 |
GO:00068872 | Colorectum | CRC | exocytosis | 55/2078 | 352/18723 | 5.62e-03 | 4.24e-02 | 55 |
GO:00224069 | Esophagus | ESCC | membrane docking | 62/8552 | 86/18723 | 5.93e-07 | 7.79e-06 | 62 |
GO:01400567 | Esophagus | ESCC | organelle localization by membrane tethering | 53/8552 | 77/18723 | 3.33e-05 | 2.74e-04 | 53 |
GO:00482781 | Esophagus | ESCC | vesicle docking | 38/8552 | 59/18723 | 2.86e-03 | 1.21e-02 | 38 |
GO:00224066 | Lung | IAC | membrane docking | 18/2061 | 86/18723 | 5.26e-03 | 3.99e-02 | 18 |
GO:00224067 | Prostate | BPH | membrane docking | 23/3107 | 86/18723 | 1.15e-02 | 4.68e-02 | 23 |
GO:002240612 | Prostate | Tumor | membrane docking | 26/3246 | 86/18723 | 2.29e-03 | 1.29e-02 | 26 |
GO:002240615 | Thyroid | PTC | membrane docking | 48/5968 | 86/18723 | 3.72e-06 | 4.73e-05 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SYTL2 | SNV | Missense_Mutation | novel | c.2281N>T | p.Ala761Ser | p.A761S | Q9HCH5 | protein_coding | tolerated(1) | benign(0.018) | TCGA-2Y-A9GZ-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Targeted Molecular therapy | sorafenib | PD |
SYTL2 | SNV | Missense_Mutation | novel | c.2522N>G | p.Asn841Ser | p.N841S | Q9HCH5 | protein_coding | tolerated(0.05) | benign(0.306) | TCGA-CC-A9FS-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
SYTL2 | SNV | Missense_Mutation | c.1535N>T | p.Ser512Ile | p.S512I | Q9HCH5 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
SYTL2 | SNV | Missense_Mutation | c.1313N>T | p.Ser438Leu | p.S438L | Q9HCH5 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-55-8207-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SYTL2 | SNV | Missense_Mutation | novel | c.2194G>T | p.Gly732Trp | p.G732W | Q9HCH5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-69-A59K-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SYTL2 | SNV | Missense_Mutation | rs562772705 | c.1196G>A | p.Ser399Asn | p.S399N | Q9HCH5 | protein_coding | tolerated(0.26) | benign(0.015) | TCGA-MP-A4TD-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
SYTL2 | SNV | Missense_Mutation | rs377321313 | c.226N>G | p.Met76Val | p.M76V | Q9HCH5 | protein_coding | deleterious(0) | benign(0.097) | TCGA-MP-A4TF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | navelbine | PD |
SYTL2 | SNV | Missense_Mutation | novel | c.716N>C | p.Arg239Thr | p.R239T | Q9HCH5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-18-4083-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
SYTL2 | SNV | Missense_Mutation | novel | c.1258G>T | p.Gly420Trp | p.G420W | Q9HCH5 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-21-1070-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SYTL2 | SNV | Missense_Mutation | c.696G>T | p.Lys232Asn | p.K232N | Q9HCH5 | protein_coding | deleterious(0.03) | probably_damaging(0.933) | TCGA-21-1070-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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