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Gene: SUPT20H |
Gene summary for SUPT20H |
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Gene information | Species | Human | Gene symbol | SUPT20H | Gene ID | 55578 |
Gene name | SPT20 homolog, SAGA complex component | |
Gene Alias | C13 | |
Cytomap | 13q13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8NEM7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55578 | SUPT20H | LZE2T | Human | Esophagus | ESCC | 1.72e-03 | 3.02e-01 | 0.082 |
55578 | SUPT20H | LZE3D | Human | Esophagus | HGIN | 4.59e-02 | 4.24e-01 | 0.0668 |
55578 | SUPT20H | LZE4T | Human | Esophagus | ESCC | 1.73e-14 | 3.71e-01 | 0.0811 |
55578 | SUPT20H | LZE5T | Human | Esophagus | ESCC | 1.35e-05 | 4.29e-01 | 0.0514 |
55578 | SUPT20H | LZE7T | Human | Esophagus | ESCC | 5.06e-09 | 4.30e-01 | 0.0667 |
55578 | SUPT20H | LZE8T | Human | Esophagus | ESCC | 5.99e-15 | 2.46e-01 | 0.067 |
55578 | SUPT20H | LZE20T | Human | Esophagus | ESCC | 2.76e-03 | 1.47e-01 | 0.0662 |
55578 | SUPT20H | LZE21D1 | Human | Esophagus | HGIN | 2.20e-03 | 3.02e-01 | 0.0632 |
55578 | SUPT20H | LZE24T | Human | Esophagus | ESCC | 1.03e-19 | 3.00e-01 | 0.0596 |
55578 | SUPT20H | LZE21T | Human | Esophagus | ESCC | 3.78e-09 | 3.05e-01 | 0.0655 |
55578 | SUPT20H | LZE6T | Human | Esophagus | ESCC | 1.54e-02 | 1.43e-01 | 0.0845 |
55578 | SUPT20H | P1T-E | Human | Esophagus | ESCC | 2.61e-13 | 5.67e-01 | 0.0875 |
55578 | SUPT20H | P2T-E | Human | Esophagus | ESCC | 5.22e-43 | 5.57e-01 | 0.1177 |
55578 | SUPT20H | P4T-E | Human | Esophagus | ESCC | 5.86e-19 | 3.93e-01 | 0.1323 |
55578 | SUPT20H | P5T-E | Human | Esophagus | ESCC | 8.35e-13 | 1.67e-01 | 0.1327 |
55578 | SUPT20H | P8T-E | Human | Esophagus | ESCC | 3.83e-49 | 8.84e-01 | 0.0889 |
55578 | SUPT20H | P9T-E | Human | Esophagus | ESCC | 1.41e-14 | 3.06e-01 | 0.1131 |
55578 | SUPT20H | P10T-E | Human | Esophagus | ESCC | 1.34e-39 | 5.88e-01 | 0.116 |
55578 | SUPT20H | P11T-E | Human | Esophagus | ESCC | 3.29e-09 | 4.29e-01 | 0.1426 |
55578 | SUPT20H | P12T-E | Human | Esophagus | ESCC | 5.32e-22 | 3.43e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00073698 | Esophagus | ESCC | gastrulation | 115/8552 | 185/18723 | 4.35e-06 | 4.64e-05 | 115 |
GO:00073697 | Oral cavity | OSCC | gastrulation | 95/7305 | 185/18723 | 4.17e-04 | 2.54e-03 | 95 |
GO:000736913 | Oral cavity | EOLP | gastrulation | 39/2218 | 185/18723 | 2.29e-04 | 2.25e-03 | 39 |
GO:000736910 | Thyroid | PTC | gastrulation | 84/5968 | 185/18723 | 7.58e-05 | 6.52e-04 | 84 |
GO:000736915 | Thyroid | ATC | gastrulation | 90/6293 | 185/18723 | 1.54e-05 | 1.43e-04 | 90 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414010 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0414015 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa041406 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa0414011 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa0414021 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa0414031 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa041409 | Oral cavity | OSCC | Autophagy - animal | 94/3704 | 141/8465 | 2.73e-08 | 2.38e-07 | 1.21e-07 | 94 |
hsa0414014 | Oral cavity | OSCC | Autophagy - animal | 94/3704 | 141/8465 | 2.73e-08 | 2.38e-07 | 1.21e-07 | 94 |
hsa0414024 | Oral cavity | LP | Autophagy - animal | 55/2418 | 141/8465 | 4.54e-03 | 1.87e-02 | 1.20e-02 | 55 |
hsa0414034 | Oral cavity | LP | Autophagy - animal | 55/2418 | 141/8465 | 4.54e-03 | 1.87e-02 | 1.20e-02 | 55 |
hsa0414041 | Oral cavity | EOLP | Autophagy - animal | 39/1218 | 141/8465 | 2.68e-05 | 1.38e-04 | 8.12e-05 | 39 |
hsa0414051 | Oral cavity | EOLP | Autophagy - animal | 39/1218 | 141/8465 | 2.68e-05 | 1.38e-04 | 8.12e-05 | 39 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SUPT20H | SNV | Missense_Mutation | c.1489C>T | p.Pro497Ser | p.P497S | Q8NEM7 | protein_coding | tolerated(0.22) | probably_damaging(0.992) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SUPT20H | SNV | Missense_Mutation | c.715N>G | p.Lys239Glu | p.K239E | Q8NEM7 | protein_coding | deleterious(0) | possibly_damaging(0.692) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
SUPT20H | SNV | Missense_Mutation | c.376G>A | p.Asp126Asn | p.D126N | Q8NEM7 | protein_coding | tolerated(0.07) | possibly_damaging(0.759) | TCGA-VQ-A94R-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD | |
SUPT20H | insertion | In_Frame_Ins | novel | c.2168_2169insAACAGTACAGGAAAT | p.Gln723_Phe724insThrValGlnGluMet | p.Q723_F724insTVQEM | Q8NEM7 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
SUPT20H | insertion | Frame_Shift_Ins | novel | c.1704_1705insCTACATT | p.Asp569LeufsTer3 | p.D569Lfs*3 | Q8NEM7 | protein_coding | TCGA-EL-A3ZM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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