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Gene: SUN1 |
Gene summary for SUN1 |
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Gene information | Species | Human | Gene symbol | SUN1 | Gene ID | 23353 |
Gene name | Sad1 and UNC84 domain containing 1 | |
Gene Alias | UNC84A | |
Cytomap | 7p22.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O94901 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23353 | SUN1 | LZE2T | Human | Esophagus | ESCC | 3.23e-02 | 3.87e-01 | 0.082 |
23353 | SUN1 | LZE4T | Human | Esophagus | ESCC | 7.23e-18 | 2.31e-01 | 0.0811 |
23353 | SUN1 | LZE5T | Human | Esophagus | ESCC | 6.04e-04 | 3.00e-01 | 0.0514 |
23353 | SUN1 | LZE7T | Human | Esophagus | ESCC | 3.79e-04 | 3.12e-01 | 0.0667 |
23353 | SUN1 | LZE8T | Human | Esophagus | ESCC | 1.89e-06 | 1.35e-01 | 0.067 |
23353 | SUN1 | LZE22D1 | Human | Esophagus | HGIN | 9.75e-05 | 1.85e-02 | 0.0595 |
23353 | SUN1 | LZE22T | Human | Esophagus | ESCC | 1.62e-06 | 7.09e-01 | 0.068 |
23353 | SUN1 | LZE24T | Human | Esophagus | ESCC | 2.28e-08 | 2.43e-01 | 0.0596 |
23353 | SUN1 | LZE21T | Human | Esophagus | ESCC | 4.20e-05 | 6.21e-01 | 0.0655 |
23353 | SUN1 | P1T-E | Human | Esophagus | ESCC | 1.51e-09 | 7.25e-01 | 0.0875 |
23353 | SUN1 | P2T-E | Human | Esophagus | ESCC | 3.82e-23 | 3.77e-01 | 0.1177 |
23353 | SUN1 | P4T-E | Human | Esophagus | ESCC | 1.51e-18 | 4.43e-01 | 0.1323 |
23353 | SUN1 | P5T-E | Human | Esophagus | ESCC | 2.22e-23 | 4.10e-01 | 0.1327 |
23353 | SUN1 | P8T-E | Human | Esophagus | ESCC | 4.09e-29 | 6.81e-01 | 0.0889 |
23353 | SUN1 | P9T-E | Human | Esophagus | ESCC | 5.10e-19 | 2.95e-01 | 0.1131 |
23353 | SUN1 | P10T-E | Human | Esophagus | ESCC | 1.08e-33 | 6.92e-01 | 0.116 |
23353 | SUN1 | P11T-E | Human | Esophagus | ESCC | 1.05e-09 | 6.92e-01 | 0.1426 |
23353 | SUN1 | P12T-E | Human | Esophagus | ESCC | 2.66e-36 | 7.89e-01 | 0.1122 |
23353 | SUN1 | P15T-E | Human | Esophagus | ESCC | 2.57e-20 | 5.22e-01 | 0.1149 |
23353 | SUN1 | P16T-E | Human | Esophagus | ESCC | 1.25e-22 | 3.29e-01 | 0.1153 |
Page: 1 2 3 4 5 6 7 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003450417 | Esophagus | HGIN | protein localization to nucleus | 84/2587 | 290/18723 | 1.06e-11 | 1.24e-09 | 84 |
GO:005165616 | Esophagus | HGIN | establishment of organelle localization | 90/2587 | 390/18723 | 4.27e-07 | 1.94e-05 | 90 |
GO:005165126 | Esophagus | HGIN | maintenance of location in cell | 53/2587 | 214/18723 | 1.22e-05 | 3.45e-04 | 53 |
GO:005123520 | Esophagus | HGIN | maintenance of location | 73/2587 | 327/18723 | 1.73e-05 | 4.71e-04 | 73 |
GO:004518523 | Esophagus | HGIN | maintenance of protein location | 28/2587 | 94/18723 | 4.52e-05 | 1.09e-03 | 28 |
GO:00500003 | Esophagus | HGIN | chromosome localization | 24/2587 | 82/18723 | 2.07e-04 | 3.82e-03 | 24 |
GO:00069975 | Esophagus | HGIN | nucleus organization | 34/2587 | 133/18723 | 2.20e-04 | 4.00e-03 | 34 |
GO:003070517 | Esophagus | HGIN | cytoskeleton-dependent intracellular transport | 45/2587 | 195/18723 | 3.07e-04 | 5.15e-03 | 45 |
GO:003250719 | Esophagus | HGIN | maintenance of protein location in cell | 20/2587 | 65/18723 | 3.31e-04 | 5.48e-03 | 20 |
GO:00070593 | Esophagus | HGIN | chromosome segregation | 71/2587 | 346/18723 | 3.47e-04 | 5.62e-03 | 71 |
GO:00513033 | Esophagus | HGIN | establishment of chromosome localization | 23/2587 | 80/18723 | 3.71e-04 | 5.77e-03 | 23 |
GO:00514575 | Esophagus | HGIN | maintenance of protein location in nucleus | 10/2587 | 23/18723 | 5.09e-04 | 7.38e-03 | 10 |
GO:00725959 | Esophagus | HGIN | maintenance of protein localization in organelle | 14/2587 | 42/18723 | 1.05e-03 | 1.31e-02 | 14 |
GO:00109707 | Esophagus | HGIN | transport along microtubule | 35/2587 | 155/18723 | 2.01e-03 | 2.12e-02 | 35 |
GO:00069983 | Esophagus | HGIN | nuclear envelope organization | 14/2587 | 47/18723 | 3.49e-03 | 3.23e-02 | 14 |
GO:000150316 | Esophagus | HGIN | ossification | 75/2587 | 408/18723 | 5.49e-03 | 4.49e-02 | 75 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SUN1 | insertion | Frame_Shift_Ins | novel | c.1566_1567insTTCATATT | p.Glu523PhefsTer23 | p.E523Ffs*23 | O94901 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
Page: 1 2 3 4 5 6 7 8 9 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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