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Gene: SPAG17 |
Gene summary for SPAG17 |
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Gene information | Species | Human | Gene symbol | SPAG17 | Gene ID | 200162 |
Gene name | sperm associated antigen 17 | |
Gene Alias | CT143 | |
Cytomap | 1p12 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q6Q759 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
200162 | SPAG17 | PTC06 | Human | Thyroid | PTC | 4.17e-03 | 1.36e-01 | 0.2057 |
200162 | SPAG17 | ATC13 | Human | Thyroid | ATC | 1.50e-35 | 6.29e-01 | 0.34 |
200162 | SPAG17 | ATC5 | Human | Thyroid | ATC | 1.46e-39 | 6.82e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00991115 | Thyroid | PTC | microtubule-based transport | 88/5968 | 190/18723 | 2.08e-05 | 2.08e-04 | 88 |
GO:009911112 | Thyroid | ATC | microtubule-based transport | 91/6293 | 190/18723 | 2.97e-05 | 2.48e-04 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPAG17 | SNV | Missense_Mutation | c.3913C>A | p.Leu1305Ile | p.L1305I | Q6Q759 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SPAG17 | SNV | Missense_Mutation | rs752984592 | c.3398C>T | p.Ser1133Leu | p.S1133L | Q6Q759 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SPAG17 | SNV | Missense_Mutation | novel | c.868A>C | p.Lys290Gln | p.K290Q | Q6Q759 | protein_coding | deleterious(0.01) | possibly_damaging(0.74) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SPAG17 | SNV | Missense_Mutation | novel | c.185G>A | p.Arg62His | p.R62H | Q6Q759 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SPAG17 | insertion | Frame_Shift_Ins | novel | c.10_11insC | p.Lys4ThrfsTer13 | p.K4Tfs*13 | Q6Q759 | protein_coding | TCGA-AA-A02J-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
SPAG17 | insertion | Frame_Shift_Ins | novel | c.4821dupA | p.Leu1608IlefsTer4 | p.L1608Ifs*4 | Q6Q759 | protein_coding | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
SPAG17 | deletion | Frame_Shift_Del | c.282delA | p.Lys94AsnfsTer3 | p.K94Nfs*3 | Q6Q759 | protein_coding | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |||
SPAG17 | insertion | Frame_Shift_Ins | rs771461785 | c.282_283insA | p.Pro95ThrfsTer5 | p.P95Tfs*5 | Q6Q759 | protein_coding | TCGA-EI-6514-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fu | SD | ||
SPAG17 | SNV | Missense_Mutation | rs752531506 | c.5588N>T | p.Thr1863Ile | p.T1863I | Q6Q759 | protein_coding | tolerated(0.06) | benign(0.005) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SPAG17 | SNV | Missense_Mutation | novel | c.5504N>G | p.Lys1835Arg | p.K1835R | Q6Q759 | protein_coding | tolerated(0.19) | benign(0.442) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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