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Gene: SMURF1 |
Gene summary for SMURF1 |
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Gene information | Species | Human | Gene symbol | SMURF1 | Gene ID | 57154 |
Gene name | SMAD specific E3 ubiquitin protein ligase 1 | |
Gene Alias | SMURF1 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q9HCE7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57154 | SMURF1 | CCI_1 | Human | Cervix | CC | 1.15e-25 | 2.34e+00 | 0.528 |
57154 | SMURF1 | CCI_2 | Human | Cervix | CC | 9.47e-17 | 1.65e+00 | 0.5249 |
57154 | SMURF1 | CCI_3 | Human | Cervix | CC | 6.68e-29 | 1.28e+00 | 0.516 |
57154 | SMURF1 | CCII_1 | Human | Cervix | CC | 4.70e-06 | 3.65e-01 | 0.3249 |
57154 | SMURF1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.43e-17 | -4.87e-01 | 0.0155 |
57154 | SMURF1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.34e-05 | -5.38e-01 | -0.1207 |
57154 | SMURF1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.36e-07 | -4.89e-01 | 0.096 |
57154 | SMURF1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.51e-04 | -6.88e-01 | 0.0528 |
57154 | SMURF1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.18e-05 | -3.91e-01 | 0.0674 |
57154 | SMURF1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.42e-12 | -4.36e-01 | 0.294 |
57154 | SMURF1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.02e-16 | -5.63e-01 | 0.3005 |
57154 | SMURF1 | A001-C-207 | Human | Colorectum | FAP | 8.20e-03 | -1.87e-01 | 0.1278 |
57154 | SMURF1 | A015-C-203 | Human | Colorectum | FAP | 5.53e-34 | -5.54e-01 | -0.1294 |
57154 | SMURF1 | A015-C-204 | Human | Colorectum | FAP | 1.06e-10 | -4.90e-01 | -0.0228 |
57154 | SMURF1 | A014-C-040 | Human | Colorectum | FAP | 3.38e-04 | -9.03e-02 | -0.1184 |
57154 | SMURF1 | A002-C-201 | Human | Colorectum | FAP | 2.27e-13 | -2.83e-01 | 0.0324 |
57154 | SMURF1 | A002-C-203 | Human | Colorectum | FAP | 1.12e-02 | 3.30e-02 | 0.2786 |
57154 | SMURF1 | A001-C-119 | Human | Colorectum | FAP | 4.94e-10 | -3.95e-01 | -0.1557 |
57154 | SMURF1 | A001-C-108 | Human | Colorectum | FAP | 1.90e-17 | -3.73e-01 | -0.0272 |
57154 | SMURF1 | A002-C-205 | Human | Colorectum | FAP | 4.33e-32 | -6.29e-01 | -0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:004586210 | Cervix | CC | positive regulation of proteolysis | 95/2311 | 372/18723 | 1.84e-12 | 6.86e-10 | 95 |
GO:190336210 | Cervix | CC | regulation of cellular protein catabolic process | 72/2311 | 255/18723 | 5.98e-12 | 2.10e-09 | 72 |
GO:004573210 | Cervix | CC | positive regulation of protein catabolic process | 65/2311 | 231/18723 | 7.44e-11 | 1.39e-08 | 65 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:190305010 | Cervix | CC | regulation of proteolysis involved in cellular protein catabolic process | 60/2311 | 221/18723 | 1.82e-09 | 1.98e-07 | 60 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:200005810 | Cervix | CC | regulation of ubiquitin-dependent protein catabolic process | 47/2311 | 164/18723 | 1.63e-08 | 1.25e-06 | 47 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:00069139 | Cervix | CC | nucleocytoplasmic transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00511699 | Cervix | CC | nuclear transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:00002097 | Cervix | CC | protein polyubiquitination | 58/2311 | 236/18723 | 1.57e-07 | 7.41e-06 | 58 |
GO:190336410 | Cervix | CC | positive regulation of cellular protein catabolic process | 43/2311 | 155/18723 | 1.80e-07 | 8.28e-06 | 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412014 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0452020 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0412015 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa04520110 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa045202 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa041202 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |
hsa04350 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa045203 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa041203 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |
hsa043501 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMURF1 | SNV | Missense_Mutation | c.1090N>G | p.Leu364Val | p.L364V | Q9HCE7 | protein_coding | tolerated(0.63) | benign(0) | TCGA-66-2773-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SMURF1 | insertion | Frame_Shift_Ins | novel | c.958_959insT | p.Gly320ValfsTer9 | p.G320Vfs*9 | Q9HCE7 | protein_coding | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
SMURF1 | deletion | In_Frame_Del | novel | c.1395_1403delNNNNNNNNN | p.Ser466_Asp468del | p.S466_D468del | Q9HCE7 | protein_coding | TCGA-33-6738-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemcitabine | SD | ||
SMURF1 | SNV | Missense_Mutation | novel | c.233N>G | p.Ile78Ser | p.I78S | Q9HCE7 | protein_coding | deleterious(0) | possibly_damaging(0.882) | TCGA-CN-5359-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
SMURF1 | SNV | Missense_Mutation | novel | c.1540N>C | p.Phe514Leu | p.F514L | Q9HCE7 | protein_coding | tolerated(0.15) | possibly_damaging(0.879) | TCGA-CX-7082-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SMURF1 | SNV | Missense_Mutation | novel | c.613C>G | p.Gln205Glu | p.Q205E | Q9HCE7 | protein_coding | tolerated(1) | benign(0.028) | TCGA-QK-A6II-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
SMURF1 | insertion | Frame_Shift_Ins | novel | c.984_985insTTTGACCATGCTTATTATCC | p.Asn329PhefsTer22 | p.N329Ffs*22 | Q9HCE7 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD | ||
SMURF1 | SNV | Missense_Mutation | c.1975N>A | p.Val659Met | p.V659M | Q9HCE7 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
SMURF1 | SNV | Missense_Mutation | novel | c.962N>A | p.Arg321Lys | p.R321K | Q9HCE7 | protein_coding | deleterious(0.02) | possibly_damaging(0.869) | TCGA-3M-AB46-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | fluorouracil | CR |
SMURF1 | SNV | Missense_Mutation | rs772381691 | c.701N>T | p.Pro234Leu | p.P234L | Q9HCE7 | protein_coding | tolerated(0.51) | benign(0.001) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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