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Gene: SLFN5 |
Gene summary for SLFN5 |
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Gene information | Species | Human | Gene symbol | SLFN5 | Gene ID | 162394 |
Gene name | schlafen family member 5 | |
Gene Alias | SLFN5 | |
Cytomap | 17q12 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | B4E128 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
162394 | SLFN5 | CA_HPV_3 | Human | Cervix | CC | 6.33e-09 | -4.55e-01 | 0.0414 |
162394 | SLFN5 | CCII_1 | Human | Cervix | CC | 2.90e-12 | -6.27e-01 | 0.3249 |
162394 | SLFN5 | sample1 | Human | Cervix | CC | 6.93e-04 | -5.24e-01 | 0.0959 |
162394 | SLFN5 | L1 | Human | Cervix | CC | 5.13e-08 | -5.49e-01 | 0.0802 |
162394 | SLFN5 | T1 | Human | Cervix | CC | 4.02e-07 | -4.76e-01 | 0.0918 |
162394 | SLFN5 | T3 | Human | Cervix | CC | 2.88e-03 | -1.88e-01 | 0.1389 |
162394 | SLFN5 | LZE4T | Human | Esophagus | ESCC | 1.44e-14 | 4.44e-01 | 0.0811 |
162394 | SLFN5 | LZE5T | Human | Esophagus | ESCC | 8.69e-04 | 4.20e-01 | 0.0514 |
162394 | SLFN5 | LZE8T | Human | Esophagus | ESCC | 5.15e-13 | 3.97e-01 | 0.067 |
162394 | SLFN5 | LZE20T | Human | Esophagus | ESCC | 1.06e-02 | 2.96e-01 | 0.0662 |
162394 | SLFN5 | LZE22D1 | Human | Esophagus | HGIN | 8.35e-03 | 1.73e-01 | 0.0595 |
162394 | SLFN5 | LZE24T | Human | Esophagus | ESCC | 4.52e-14 | 6.13e-01 | 0.0596 |
162394 | SLFN5 | LZE21T | Human | Esophagus | ESCC | 1.99e-09 | 6.11e-01 | 0.0655 |
162394 | SLFN5 | LZE6T | Human | Esophagus | ESCC | 2.63e-04 | 2.50e-01 | 0.0845 |
162394 | SLFN5 | P1T-E | Human | Esophagus | ESCC | 9.76e-12 | 7.04e-01 | 0.0875 |
162394 | SLFN5 | P2T-E | Human | Esophagus | ESCC | 1.88e-07 | 2.04e-01 | 0.1177 |
162394 | SLFN5 | P4T-E | Human | Esophagus | ESCC | 6.13e-14 | 2.70e-01 | 0.1323 |
162394 | SLFN5 | P5T-E | Human | Esophagus | ESCC | 2.54e-09 | 2.21e-01 | 0.1327 |
162394 | SLFN5 | P8T-E | Human | Esophagus | ESCC | 1.49e-24 | 4.84e-01 | 0.0889 |
162394 | SLFN5 | P9T-E | Human | Esophagus | ESCC | 2.89e-08 | 2.92e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLFN5 | SNV | Missense_Mutation | novel | c.2140A>T | p.Asn714Tyr | p.N714Y | Q08AF3 | protein_coding | deleterious(0.02) | benign(0) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SLFN5 | SNV | Missense_Mutation | c.178G>T | p.Ala60Ser | p.A60S | Q08AF3 | protein_coding | deleterious(0.05) | possibly_damaging(0.515) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
SLFN5 | SNV | Missense_Mutation | novel | c.259G>T | p.Asp87Tyr | p.D87Y | Q08AF3 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLFN5 | SNV | Missense_Mutation | c.748A>T | p.Ser250Cys | p.S250C | Q08AF3 | protein_coding | deleterious(0.01) | benign(0.382) | TCGA-21-1070-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SLFN5 | SNV | Missense_Mutation | rs763472910 | c.1234C>T | p.Arg412Cys | p.R412C | Q08AF3 | protein_coding | tolerated(0.06) | benign(0.005) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLFN5 | SNV | Missense_Mutation | novel | c.757N>T | p.Ala253Ser | p.A253S | Q08AF3 | protein_coding | tolerated(0.69) | benign(0.003) | TCGA-60-2715-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | PD |
SLFN5 | SNV | Missense_Mutation | novel | c.2575N>C | p.Ile859Leu | p.I859L | Q08AF3 | protein_coding | deleterious(0.03) | benign(0.006) | TCGA-60-2715-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | PD |
SLFN5 | SNV | Missense_Mutation | novel | c.554N>G | p.Glu185Gly | p.E185G | Q08AF3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-77-6843-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLFN5 | SNV | Missense_Mutation | novel | c.31T>G | p.Phe11Val | p.F11V | Q08AF3 | protein_coding | deleterious(0.01) | benign(0.177) | TCGA-NC-A5HM-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLFN5 | SNV | Missense_Mutation | novel | c.2603G>A | p.Gly868Glu | p.G868E | Q08AF3 | protein_coding | tolerated(0.07) | benign(0.092) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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