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Gene: SLC6A11 |
Gene summary for SLC6A11 |
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Gene information | Species | Human | Gene symbol | SLC6A11 | Gene ID | 6538 |
Gene name | solute carrier family 6 member 11 | |
Gene Alias | GAT-3 | |
Cytomap | 3p25.3 | |
Gene Type | protein-coding | GO ID | GO:0001504 | UniProtAcc | P48066 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6538 | SLC6A11 | P5T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.77e-01 | 0.1327 |
6538 | SLC6A11 | P10T-E | Human | Esophagus | ESCC | 3.50e-02 | 9.83e-02 | 0.116 |
6538 | SLC6A11 | P21T-E | Human | Esophagus | ESCC | 5.00e-17 | 3.08e-01 | 0.1617 |
6538 | SLC6A11 | P22T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.15e-01 | 0.1236 |
6538 | SLC6A11 | P36T-E | Human | Esophagus | ESCC | 1.12e-06 | 2.51e-01 | 0.1187 |
6538 | SLC6A11 | P49T-E | Human | Esophagus | ESCC | 1.19e-10 | 9.76e-01 | 0.1768 |
6538 | SLC6A11 | P52T-E | Human | Esophagus | ESCC | 7.55e-03 | 6.07e-02 | 0.1555 |
6538 | SLC6A11 | P80T-E | Human | Esophagus | ESCC | 4.12e-02 | 1.26e-01 | 0.155 |
6538 | SLC6A11 | P91T-E | Human | Esophagus | ESCC | 3.82e-08 | 7.73e-01 | 0.1828 |
6538 | SLC6A11 | P128T-E | Human | Esophagus | ESCC | 3.21e-06 | 2.54e-01 | 0.1241 |
6538 | SLC6A11 | P130T-E | Human | Esophagus | ESCC | 1.53e-19 | 3.91e-01 | 0.1676 |
6538 | SLC6A11 | NAFLD1 | Human | Liver | NAFLD | 9.16e-04 | 3.81e-01 | -0.04 |
6538 | SLC6A11 | HCC1_Meng | Human | Liver | HCC | 1.42e-23 | 7.01e-02 | 0.0246 |
6538 | SLC6A11 | HCC1 | Human | Liver | HCC | 8.12e-15 | 1.32e+00 | 0.5336 |
6538 | SLC6A11 | HCC2 | Human | Liver | HCC | 6.60e-36 | 1.81e+00 | 0.5341 |
6538 | SLC6A11 | HCC5 | Human | Liver | HCC | 3.93e-42 | 1.77e+00 | 0.4932 |
6538 | SLC6A11 | S016 | Human | Liver | HCC | 1.08e-02 | 5.23e-02 | 0.2243 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:00094107 | Liver | NAFLD | response to xenobiotic stimulus | 88/1882 | 462/18723 | 2.53e-09 | 4.11e-07 | 88 |
GO:000941022 | Liver | HCC | response to xenobiotic stimulus | 248/7958 | 462/18723 | 6.47e-07 | 1.02e-05 | 248 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC6A11 | SNV | Missense_Mutation | c.455N>T | p.Ala152Val | p.A152V | P48066 | protein_coding | tolerated(0.05) | probably_damaging(0.994) | TCGA-CD-5801-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
SLC6A11 | SNV | Missense_Mutation | c.1742N>T | p.Pro581Leu | p.P581L | P48066 | protein_coding | tolerated(0.36) | benign(0) | TCGA-CG-4443-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC6A11 | SNV | Missense_Mutation | c.1771N>G | p.Ser591Gly | p.S591G | P48066 | protein_coding | tolerated(0.27) | benign(0.015) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
SLC6A11 | deletion | Frame_Shift_Del | novel | c.223delN | p.Arg75AlafsTer15 | p.R75Afs*15 | P48066 | protein_coding | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6538 | SLC6A11 | TRANSPORTER, DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | GSK683699 |
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