![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SENP6 |
Gene summary for SENP6 |
![]() |
Gene information | Species | Human | Gene symbol | SENP6 | Gene ID | 26054 |
Gene name | SUMO specific peptidase 6 | |
Gene Alias | SSP1 | |
Cytomap | 6q14.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | B3KMM0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26054 | SENP6 | CA_HPV_1 | Human | Cervix | CC | 1.56e-03 | -6.14e-02 | 0.0264 |
26054 | SENP6 | CCI_2 | Human | Cervix | CC | 1.21e-06 | 7.32e-01 | 0.5249 |
26054 | SENP6 | CCI_3 | Human | Cervix | CC | 7.60e-07 | 8.58e-01 | 0.516 |
26054 | SENP6 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.95e-33 | -7.72e-01 | 0.0155 |
26054 | SENP6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.44e-05 | -5.35e-01 | -0.1808 |
26054 | SENP6 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.56e-02 | -7.74e-01 | 0.0216 |
26054 | SENP6 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.11e-02 | -7.76e-01 | -0.2196 |
26054 | SENP6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.70e-13 | -7.94e-01 | -0.1207 |
26054 | SENP6 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.09e-12 | -4.70e-01 | -0.1464 |
26054 | SENP6 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.96e-06 | -7.20e-01 | -0.2061 |
26054 | SENP6 | HTA11_9341_2000001011 | Human | Colorectum | SER | 5.74e-03 | -8.27e-01 | -0.00410000000000005 |
26054 | SENP6 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.34e-08 | -5.19e-01 | 0.096 |
26054 | SENP6 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.47e-02 | -7.44e-01 | 0.0451 |
26054 | SENP6 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.73e-03 | -6.80e-01 | 0.0528 |
26054 | SENP6 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.43e-04 | -4.30e-01 | 0.0338 |
26054 | SENP6 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.03e-04 | -3.62e-01 | 0.0674 |
26054 | SENP6 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.51e-02 | -8.11e-01 | 0.0397 |
26054 | SENP6 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.71e-04 | -3.59e-01 | 0.294 |
26054 | SENP6 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.30e-08 | -4.06e-01 | 0.3859 |
26054 | SENP6 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.95e-03 | -5.53e-01 | 0.2585 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:19021153 | Cervix | CC | regulation of organelle assembly | 40/2311 | 186/18723 | 2.92e-04 | 3.15e-03 | 40 |
GO:00705074 | Cervix | CC | regulation of microtubule cytoskeleton organization | 32/2311 | 148/18723 | 1.02e-03 | 8.51e-03 | 32 |
GO:00182054 | Cervix | CC | peptidyl-lysine modification | 62/2311 | 376/18723 | 1.04e-02 | 4.97e-02 | 62 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0033044 | Colorectum | AD | regulation of chromosome organization | 60/3918 | 187/18723 | 2.25e-04 | 2.94e-03 | 60 |
GO:0007051 | Colorectum | AD | spindle organization | 58/3918 | 184/18723 | 4.71e-04 | 5.20e-03 | 58 |
GO:0051225 | Colorectum | AD | spindle assembly | 37/3918 | 117/18723 | 4.32e-03 | 2.96e-02 | 37 |
GO:0070507 | Colorectum | AD | regulation of microtubule cytoskeleton organization | 44/3918 | 148/18723 | 7.05e-03 | 4.31e-02 | 44 |
GO:0090169 | Colorectum | AD | regulation of spindle assembly | 11/3918 | 25/18723 | 7.89e-03 | 4.73e-02 | 11 |
GO:00432541 | Colorectum | SER | regulation of protein-containing complex assembly | 119/2897 | 428/18723 | 3.34e-11 | 5.86e-09 | 119 |
GO:00901691 | Colorectum | SER | regulation of spindle assembly | 10/2897 | 25/18723 | 2.70e-03 | 2.44e-02 | 10 |
GO:0090224 | Colorectum | SER | regulation of spindle organization | 13/2897 | 39/18723 | 4.39e-03 | 3.51e-02 | 13 |
GO:00432542 | Colorectum | MSS | regulation of protein-containing complex assembly | 130/3467 | 428/18723 | 1.38e-09 | 1.03e-07 | 130 |
GO:00330441 | Colorectum | MSS | regulation of chromosome organization | 55/3467 | 187/18723 | 1.86e-04 | 2.63e-03 | 55 |
GO:00070511 | Colorectum | MSS | spindle organization | 53/3467 | 184/18723 | 4.23e-04 | 5.19e-03 | 53 |
GO:00512251 | Colorectum | MSS | spindle assembly | 33/3467 | 117/18723 | 6.68e-03 | 4.38e-02 | 33 |
GO:00432544 | Colorectum | FAP | regulation of protein-containing complex assembly | 101/2622 | 428/18723 | 5.18e-08 | 4.07e-06 | 101 |
GO:00330442 | Colorectum | FAP | regulation of chromosome organization | 46/2622 | 187/18723 | 7.41e-05 | 1.36e-03 | 46 |
GO:00070512 | Colorectum | FAP | spindle organization | 41/2622 | 184/18723 | 1.50e-03 | 1.34e-02 | 41 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SENP6 | SNV | Missense_Mutation | novel | c.3045G>T | p.Lys1015Asn | p.K1015N | Q9GZR1 | protein_coding | deleterious(0) | possibly_damaging(0.675) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
SENP6 | SNV | Missense_Mutation | c.1009G>A | p.Asp337Asn | p.D337N | Q9GZR1 | protein_coding | deleterious(0) | possibly_damaging(0.576) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
SENP6 | SNV | Missense_Mutation | c.2928G>T | p.Met976Ile | p.M976I | Q9GZR1 | protein_coding | deleterious(0) | possibly_damaging(0.505) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
SENP6 | SNV | Missense_Mutation | novel | c.796C>G | p.Gln266Glu | p.Q266E | Q9GZR1 | protein_coding | tolerated(0.71) | benign(0.072) | TCGA-44-A47F-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | alimta | CR |
SENP6 | SNV | Missense_Mutation | c.986A>T | p.Asn329Ile | p.N329I | Q9GZR1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
SENP6 | SNV | Missense_Mutation | novel | c.1936N>T | p.Ile646Phe | p.I646F | Q9GZR1 | protein_coding | deleterious(0.02) | benign(0.199) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
SENP6 | SNV | Missense_Mutation | novel | c.2152N>G | p.Leu718Val | p.L718V | Q9GZR1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-75-6211-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD |
SENP6 | SNV | Missense_Mutation | novel | c.3205N>A | p.Glu1069Lys | p.E1069K | Q9GZR1 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SENP6 | SNV | Missense_Mutation | novel | c.1404N>G | p.Asp468Glu | p.D468E | Q9GZR1 | protein_coding | tolerated(0.12) | benign(0.015) | TCGA-MP-A4T8-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | navelbine | SD |
SENP6 | SNV | Missense_Mutation | novel | c.1043N>T | p.Arg348Ile | p.R348I | Q9GZR1 | protein_coding | tolerated(0.38) | benign(0.013) | TCGA-NJ-A4YF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | GNF-PF-1702 | CHEMBL600313 | ||
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | CID 4101591 | CHEMBL428789 | ||
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | DNDI1417156 | CHEMBL1504679 | ||
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | DIHYDROXANTHOHUMOL | DIHYDROXANTHOHUMOL | ||
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | IPRIFLAVONE | IPRIFLAVONE | ||
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | XANTHOANGELOL B | XANTHOANGELOL B | ||
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | 4-PHENYLAMINO-[1,2]NAPHTHOQUINONE | CHEMBL299853 | ||
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | 6,4'-DIHYDROXYFLAVONE | CHEMBL484663 | ||
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | 2-(4-NITROBENZYLSULFANYL)BENZOXAZOLE | CHEMBL412603 | ||
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | BAS-0338868 | CHEMBL378903 |
Page: 1 2 |