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Gene: SEL1L3 |
Gene summary for SEL1L3 |
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Gene information | Species | Human | Gene symbol | SEL1L3 | Gene ID | 23231 |
Gene name | SEL1L family member 3 | |
Gene Alias | Sel-1L3 | |
Cytomap | 4p15.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q68CR1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23231 | SEL1L3 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.82e-03 | 5.74e-01 | -0.1088 |
23231 | SEL1L3 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.22e-14 | 7.43e-01 | -0.1954 |
23231 | SEL1L3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.32e-04 | 9.12e-01 | -0.2602 |
23231 | SEL1L3 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.35e-05 | 4.80e-01 | -0.1464 |
23231 | SEL1L3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.82e-03 | 5.25e-01 | 0.0588 |
23231 | SEL1L3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.02e-12 | 7.30e-01 | 0.294 |
23231 | SEL1L3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.91e-11 | 8.27e-01 | 0.281 |
23231 | SEL1L3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.59e-07 | 7.08e-01 | 0.3859 |
23231 | SEL1L3 | A015-C-203 | Human | Colorectum | FAP | 2.85e-24 | -3.17e-01 | -0.1294 |
23231 | SEL1L3 | A015-C-204 | Human | Colorectum | FAP | 3.36e-06 | -2.84e-01 | -0.0228 |
23231 | SEL1L3 | A014-C-040 | Human | Colorectum | FAP | 3.24e-03 | -2.11e-01 | -0.1184 |
23231 | SEL1L3 | A002-C-201 | Human | Colorectum | FAP | 2.50e-10 | -1.47e-01 | 0.0324 |
23231 | SEL1L3 | A002-C-203 | Human | Colorectum | FAP | 1.62e-02 | 1.60e-02 | 0.2786 |
23231 | SEL1L3 | A001-C-119 | Human | Colorectum | FAP | 5.19e-04 | -1.47e-01 | -0.1557 |
23231 | SEL1L3 | A001-C-108 | Human | Colorectum | FAP | 1.94e-15 | -1.27e-01 | -0.0272 |
23231 | SEL1L3 | A002-C-205 | Human | Colorectum | FAP | 1.73e-20 | -2.11e-01 | -0.1236 |
23231 | SEL1L3 | A001-C-104 | Human | Colorectum | FAP | 6.61e-04 | 3.63e-02 | 0.0184 |
23231 | SEL1L3 | A015-C-006 | Human | Colorectum | FAP | 2.44e-13 | -2.40e-01 | -0.0994 |
23231 | SEL1L3 | A015-C-106 | Human | Colorectum | FAP | 6.76e-09 | -1.02e-01 | -0.0511 |
23231 | SEL1L3 | A002-C-114 | Human | Colorectum | FAP | 1.90e-15 | -3.26e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEL1L3 | SNV | Missense_Mutation | c.3319N>T | p.Ser1107Cys | p.S1107C | Q68CR1 | protein_coding | deleterious_low_confidence(0.01) | benign(0.241) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
SEL1L3 | SNV | Missense_Mutation | novel | c.2341G>T | p.Ala781Ser | p.A781S | Q68CR1 | protein_coding | tolerated(0.2) | benign(0.109) | TCGA-91-8499-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEL1L3 | SNV | Missense_Mutation | c.2549T>G | p.Leu850Arg | p.L850R | Q68CR1 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-97-7937-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SEL1L3 | SNV | Missense_Mutation | c.1516N>C | p.Lys506Gln | p.K506Q | Q68CR1 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SEL1L3 | SNV | Missense_Mutation | c.280N>T | p.Arg94Cys | p.R94C | Q68CR1 | protein_coding | tolerated(0.2) | possibly_damaging(0.759) | TCGA-37-A5EL-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | temodal | PD | |
SEL1L3 | SNV | Missense_Mutation | novel | c.550N>G | p.Arg184Gly | p.R184G | Q68CR1 | protein_coding | tolerated(0.88) | benign(0) | TCGA-60-2695-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEL1L3 | insertion | In_Frame_Ins | novel | c.1292_1293insGTTTAA | p.Ile431delinsMetPheAsn | p.I431delinsMFN | Q68CR1 | protein_coding | TCGA-L4-A4E6-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SEL1L3 | insertion | In_Frame_Ins | novel | c.1291-1_1291insTCATAT | p.Gln430_Ile431insSerTyr | p.Q430_I431insSY | Q68CR1 | protein_coding | TCGA-L4-A4E6-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SEL1L3 | SNV | Missense_Mutation | novel | c.1976G>C | p.Arg659Thr | p.R659T | Q68CR1 | protein_coding | tolerated(0.06) | benign(0.358) | TCGA-CR-5248-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD |
SEL1L3 | SNV | Missense_Mutation | c.2345N>G | p.Lys782Arg | p.K782R | Q68CR1 | protein_coding | tolerated(0.18) | possibly_damaging(0.517) | TCGA-CH-5768-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 6 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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