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Gene: SDCCAG8 |
Gene summary for SDCCAG8 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SDCCAG8 | Gene ID | 10806 |
Gene name | SHH signaling and ciliogenesis regulator SDCCAG8 | |
Gene Alias | BBS16 | |
Cytomap | 1q43-q44 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q86SQ7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10806 | SDCCAG8 | CA_HPV_3 | Human | Cervix | CC | 1.21e-02 | 8.87e-02 | 0.0414 |
10806 | SDCCAG8 | CCI_3 | Human | Cervix | CC | 1.51e-02 | 6.55e-01 | 0.516 |
10806 | SDCCAG8 | T3 | Human | Cervix | CC | 4.48e-02 | 1.37e-01 | 0.1389 |
10806 | SDCCAG8 | LZE2T | Human | Esophagus | ESCC | 6.83e-14 | 1.99e+00 | 0.082 |
10806 | SDCCAG8 | LZE4T | Human | Esophagus | ESCC | 4.21e-24 | 6.09e-01 | 0.0811 |
10806 | SDCCAG8 | LZE5T | Human | Esophagus | ESCC | 1.15e-02 | 2.94e-01 | 0.0514 |
10806 | SDCCAG8 | LZE7T | Human | Esophagus | ESCC | 3.59e-25 | 1.35e+00 | 0.0667 |
10806 | SDCCAG8 | LZE8T | Human | Esophagus | ESCC | 1.16e-15 | 5.46e-01 | 0.067 |
10806 | SDCCAG8 | LZE20T | Human | Esophagus | ESCC | 4.39e-05 | 1.08e-01 | 0.0662 |
10806 | SDCCAG8 | LZE22D1 | Human | Esophagus | HGIN | 1.46e-11 | 5.41e-01 | 0.0595 |
10806 | SDCCAG8 | LZE22T | Human | Esophagus | ESCC | 8.66e-16 | 1.38e+00 | 0.068 |
10806 | SDCCAG8 | LZE24T | Human | Esophagus | ESCC | 6.98e-30 | 8.87e-01 | 0.0596 |
10806 | SDCCAG8 | LZE21T | Human | Esophagus | ESCC | 1.94e-14 | 6.70e-01 | 0.0655 |
10806 | SDCCAG8 | LZE6T | Human | Esophagus | ESCC | 2.56e-06 | 1.45e-01 | 0.0845 |
10806 | SDCCAG8 | P1T-E | Human | Esophagus | ESCC | 2.29e-24 | 1.51e+00 | 0.0875 |
10806 | SDCCAG8 | P2T-E | Human | Esophagus | ESCC | 1.39e-80 | 1.31e+00 | 0.1177 |
10806 | SDCCAG8 | P4T-E | Human | Esophagus | ESCC | 1.01e-38 | 9.80e-01 | 0.1323 |
10806 | SDCCAG8 | P5T-E | Human | Esophagus | ESCC | 3.27e-92 | 1.94e+00 | 0.1327 |
10806 | SDCCAG8 | P8T-E | Human | Esophagus | ESCC | 1.06e-37 | 6.64e-01 | 0.0889 |
10806 | SDCCAG8 | P9T-E | Human | Esophagus | ESCC | 1.77e-23 | 5.01e-01 | 0.1131 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00071639 | Cervix | CC | establishment or maintenance of cell polarity | 63/2311 | 218/18723 | 4.25e-11 | 8.76e-09 | 63 |
GO:00300108 | Cervix | CC | establishment of cell polarity | 42/2311 | 143/18723 | 4.30e-08 | 2.62e-06 | 42 |
GO:19021153 | Cervix | CC | regulation of organelle assembly | 40/2311 | 186/18723 | 2.92e-04 | 3.15e-03 | 40 |
GO:01200328 | Cervix | CC | regulation of plasma membrane bounded cell projection assembly | 38/2311 | 186/18723 | 1.14e-03 | 9.35e-03 | 38 |
GO:00604917 | Cervix | CC | regulation of cell projection assembly | 38/2311 | 188/18723 | 1.40e-03 | 1.10e-02 | 38 |
GO:00351487 | Cervix | CC | tube formation | 31/2311 | 148/18723 | 2.07e-03 | 1.51e-02 | 31 |
GO:19021156 | Esophagus | HGIN | regulation of organelle assembly | 46/2587 | 186/18723 | 4.63e-05 | 1.12e-03 | 46 |
GO:006049117 | Esophagus | HGIN | regulation of cell projection assembly | 39/2587 | 188/18723 | 5.61e-03 | 4.57e-02 | 39 |
GO:000716320 | Esophagus | ESCC | establishment or maintenance of cell polarity | 143/8552 | 218/18723 | 2.05e-09 | 4.65e-08 | 143 |
GO:003001018 | Esophagus | ESCC | establishment of cell polarity | 96/8552 | 143/18723 | 1.69e-07 | 2.67e-06 | 96 |
GO:003514815 | Esophagus | ESCC | tube formation | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:190211514 | Esophagus | ESCC | regulation of organelle assembly | 116/8552 | 186/18723 | 3.15e-06 | 3.53e-05 | 116 |
GO:00070982 | Esophagus | ESCC | centrosome cycle | 85/8552 | 130/18723 | 4.41e-06 | 4.69e-05 | 85 |
GO:00310233 | Esophagus | ESCC | microtubule organizing center organization | 92/8552 | 143/18723 | 5.04e-06 | 5.31e-05 | 92 |
GO:006049118 | Esophagus | ESCC | regulation of cell projection assembly | 110/8552 | 188/18723 | 2.60e-04 | 1.58e-03 | 110 |
GO:012003218 | Esophagus | ESCC | regulation of plasma membrane bounded cell projection assembly | 108/8552 | 186/18723 | 4.37e-04 | 2.46e-03 | 108 |
GO:00071636 | Liver | NAFLD | establishment or maintenance of cell polarity | 46/1882 | 218/18723 | 8.80e-07 | 4.60e-05 | 46 |
GO:00300106 | Liver | NAFLD | establishment of cell polarity | 34/1882 | 143/18723 | 1.41e-06 | 6.56e-05 | 34 |
GO:000716312 | Liver | Cirrhotic | establishment or maintenance of cell polarity | 82/4634 | 218/18723 | 1.55e-05 | 2.11e-04 | 82 |
GO:1902115 | Liver | Cirrhotic | regulation of organelle assembly | 66/4634 | 186/18723 | 6.66e-04 | 5.04e-03 | 66 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SDCCAG8 | SNV | Missense_Mutation | novel | c.329C>T | p.Thr110Ile | p.T110I | Q86SQ7 | protein_coding | tolerated(0.15) | benign(0.157) | TCGA-CV-7424-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SDCCAG8 | SNV | Missense_Mutation | novel | c.271N>A | p.Val91Ile | p.V91I | Q86SQ7 | protein_coding | tolerated(0.53) | benign(0.001) | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD |
SDCCAG8 | SNV | Missense_Mutation | novel | c.295N>C | p.Met99Leu | p.M99L | Q86SQ7 | protein_coding | tolerated(0.26) | benign(0.001) | TCGA-T2-A6WZ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cetuximab | PD |
SDCCAG8 | SNV | Missense_Mutation | rs200657425 | c.833G>A | p.Arg278His | p.R278H | Q86SQ7 | protein_coding | tolerated(0.16) | benign(0.017) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SDCCAG8 | SNV | Missense_Mutation | rs767707839 | c.934N>G | p.Arg312Gly | p.R312G | Q86SQ7 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SDCCAG8 | SNV | Missense_Mutation | rs759634630 | c.331N>G | p.Asn111Asp | p.N111D | Q86SQ7 | protein_coding | tolerated(0.56) | benign(0) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
SDCCAG8 | SNV | Missense_Mutation | novel | c.1596N>T | p.Glu532Asp | p.E532D | Q86SQ7 | protein_coding | deleterious(0.01) | possibly_damaging(0.721) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SDCCAG8 | deletion | Frame_Shift_Del | novel | c.905_926delNNNNNNNNNNNNNNNNNNNNNN | p.Met302IlefsTer7 | p.M302Ifs*7 | Q86SQ7 | protein_coding | TCGA-EL-A3GU-01 | Thyroid | thyroid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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