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Gene: ROS1 |
Gene summary for ROS1 |
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Gene information | Species | Human | Gene symbol | ROS1 | Gene ID | 6098 |
Gene name | ROS proto-oncogene 1, receptor tyrosine kinase | |
Gene Alias | MCF3 | |
Cytomap | 6q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P08922 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6098 | ROS1 | P36T-E | Human | Esophagus | ESCC | 7.91e-07 | 2.65e-01 | 0.1187 |
6098 | ROS1 | P49T-E | Human | Esophagus | ESCC | 7.48e-03 | 5.45e-01 | 0.1768 |
6098 | ROS1 | P62T-E | Human | Esophagus | ESCC | 2.57e-02 | 1.28e-01 | 0.1302 |
6098 | ROS1 | P107T-E | Human | Esophagus | ESCC | 3.76e-35 | 9.87e-01 | 0.171 |
6098 | ROS1 | TD9 | Human | Lung | IAC | 2.29e-02 | 4.31e-01 | 0.088 |
6098 | ROS1 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 7.35e-09 | 1.29e+00 | -0.1271 |
6098 | ROS1 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 6.28e-12 | 1.42e+00 | -0.1406 |
6098 | ROS1 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 3.37e-12 | 1.43e+00 | -0.1408 |
6098 | ROS1 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 1.91e-14 | 1.54e+00 | -0.138 |
6098 | ROS1 | RNA-P17T-P17T-2 | Human | Lung | IAC | 9.92e-05 | 6.11e-01 | 0.3371 |
6098 | ROS1 | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.21e-05 | 5.96e-01 | 0.343 |
6098 | ROS1 | RNA-P17T-P17T-6 | Human | Lung | IAC | 6.46e-04 | 5.65e-01 | 0.3385 |
6098 | ROS1 | RNA-P17T-P17T-8 | Human | Lung | IAC | 3.82e-05 | 4.47e-01 | 0.3329 |
6098 | ROS1 | RNA-P18T-P18T-8 | Human | Lung | IAC | 4.28e-03 | 1.25e+00 | 0.1151 |
6098 | ROS1 | RNA-P23T2-P23T2-1 | Human | Lung | MIAC | 5.56e-05 | 1.32e+00 | -0.037 |
6098 | ROS1 | RNA-P23T2-P23T2-2 | Human | Lung | MIAC | 7.61e-03 | 1.07e+00 | -0.028 |
6098 | ROS1 | RNA-P23T2-P23T2-4 | Human | Lung | MIAC | 1.00e-05 | 1.38e+00 | -0.0272 |
6098 | ROS1 | RNA-P24T2-P24T2-2 | Human | Lung | IAC | 4.40e-04 | 1.38e+00 | 0.0057 |
6098 | ROS1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 5.81e-31 | 1.35e+00 | -0.2116 |
6098 | ROS1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 7.54e-17 | 1.42e+00 | -0.1941 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:000206420 | Esophagus | ESCC | epithelial cell development | 136/8552 | 220/18723 | 9.50e-07 | 1.21e-05 | 136 |
GO:003367420 | Esophagus | ESCC | positive regulation of kinase activity | 260/8552 | 467/18723 | 7.26e-06 | 7.22e-05 | 260 |
GO:00319294 | Esophagus | ESCC | TOR signaling | 79/8552 | 126/18723 | 8.57e-05 | 6.21e-04 | 79 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00320061 | Esophagus | ESCC | regulation of TOR signaling | 63/8552 | 104/18723 | 1.55e-03 | 7.29e-03 | 63 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:0002066 | Esophagus | ESCC | columnar/cuboidal epithelial cell development | 29/8552 | 44/18723 | 5.41e-03 | 2.02e-02 | 29 |
GO:00610417 | Liver | NAFLD | regulation of wound healing | 39/1882 | 134/18723 | 5.52e-10 | 1.28e-07 | 39 |
GO:00420607 | Liver | NAFLD | wound healing | 84/1882 | 422/18723 | 6.56e-10 | 1.37e-07 | 84 |
GO:0042730 | Liver | NAFLD | fibrinolysis | 15/1882 | 25/18723 | 1.26e-09 | 2.30e-07 | 15 |
GO:0030195 | Liver | NAFLD | negative regulation of blood coagulation | 21/1882 | 49/18723 | 2.42e-09 | 4.05e-07 | 21 |
GO:1900047 | Liver | NAFLD | negative regulation of hemostasis | 21/1882 | 50/18723 | 3.78e-09 | 5.40e-07 | 21 |
GO:0030193 | Liver | NAFLD | regulation of blood coagulation | 24/1882 | 66/18723 | 9.30e-09 | 1.26e-06 | 24 |
GO:0050819 | Liver | NAFLD | negative regulation of coagulation | 21/1882 | 53/18723 | 1.33e-08 | 1.69e-06 | 21 |
GO:1900046 | Liver | NAFLD | regulation of hemostasis | 24/1882 | 68/18723 | 1.84e-08 | 2.09e-06 | 24 |
GO:0061045 | Liver | NAFLD | negative regulation of wound healing | 26/1882 | 78/18723 | 1.86e-08 | 2.09e-06 | 26 |
GO:19030347 | Liver | NAFLD | regulation of response to wounding | 41/1882 | 167/18723 | 4.70e-08 | 4.58e-06 | 41 |
GO:0050818 | Liver | NAFLD | regulation of coagulation | 24/1882 | 71/18723 | 4.80e-08 | 4.60e-06 | 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ROS1 | insertion | Frame_Shift_Ins | novel | c.1087_1088insT | p.Tyr363LeufsTer25 | p.Y363Lfs*25 | P08922 | protein_coding | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ROS1 | insertion | In_Frame_Ins | novel | c.82_83insAAGAGAAAACAATTCTAT | p.Thr28delinsLysGluLysThrIleLeuSer | p.T28delinsKEKTILS | P08922 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ROS1 | deletion | Frame_Shift_Del | c.5462delN | p.Asn1821ThrfsTer2 | p.N1821Tfs*2 | P08922 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ROS1 | insertion | Frame_Shift_Ins | rs748436511 | c.3500_3501insT | p.Leu1167PhefsTer26 | p.L1167Ffs*26 | P08922 | protein_coding | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
ROS1 | insertion | Frame_Shift_Ins | novel | c.2721_2722insA | p.Glu908ArgfsTer17 | p.E908Rfs*17 | P08922 | protein_coding | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | ||
ROS1 | SNV | Missense_Mutation | c.6037N>A | p.Leu2013Ile | p.L2013I | P08922 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ROS1 | SNV | Missense_Mutation | novel | c.6620N>T | p.Thr2207Ile | p.T2207I | P08922 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.6245N>T | p.Ala2082Val | p.A2082V | P08922 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.5563N>C | p.Phe1855Leu | p.F1855L | P08922 | protein_coding | tolerated(0.68) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.5509N>T | p.Gly1837Trp | p.G1837W | P08922 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | Imidazo[1,2-b]pyridazine derivative 2 | |||
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | ENTRECTINIB | ENTRECTINIB | 28183697 | |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | CRIZOTINIB | CRIZOTINIB | 23724914,25733882,25351743,25688157,26372962 | |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | AZD3463 | 26372962 | ||
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | TPX-0005 | |||
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | inhibitor | CRIZOTINIB | CRIZOTINIB | |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | DS6051b | |||
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | CYC-116 | CYC-116 | ||
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | CRIZOTINIB | CRIZOTINIB | 29596029,23724914,25264305,24875859,25922291,22215748,25688157,26372962,25667280,30980071,29333528 |
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