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Gene: RNF19A |
Gene summary for RNF19A |
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Gene information | Species | Human | Gene symbol | RNF19A | Gene ID | 25897 |
Gene name | ring finger protein 19A, RBR E3 ubiquitin protein ligase | |
Gene Alias | RNF19 | |
Cytomap | 8q22.2 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q9NV58 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25897 | RNF19A | GSM4909287 | Human | Breast | IDC | 2.73e-13 | 5.79e-01 | 0.2057 |
25897 | RNF19A | GSM4909290 | Human | Breast | IDC | 1.09e-11 | 4.67e-01 | 0.2096 |
25897 | RNF19A | GSM4909298 | Human | Breast | IDC | 1.87e-18 | 4.96e-01 | 0.1551 |
25897 | RNF19A | GSM4909311 | Human | Breast | IDC | 3.32e-09 | -1.52e-01 | 0.1534 |
25897 | RNF19A | GSM4909317 | Human | Breast | IDC | 3.00e-10 | 3.94e-01 | 0.1355 |
25897 | RNF19A | GSM4909319 | Human | Breast | IDC | 6.97e-12 | -8.05e-02 | 0.1563 |
25897 | RNF19A | GSM4909321 | Human | Breast | IDC | 2.92e-03 | -1.25e-01 | 0.1559 |
25897 | RNF19A | M1 | Human | Breast | IDC | 1.36e-36 | 1.00e+00 | 0.1577 |
25897 | RNF19A | NCCBC6 | Human | Breast | DCIS | 4.22e-02 | 4.85e-01 | 0.2095 |
25897 | RNF19A | P1 | Human | Breast | IDC | 5.14e-12 | 5.12e-01 | 0.1527 |
25897 | RNF19A | DCIS2 | Human | Breast | DCIS | 9.80e-45 | 2.91e-01 | 0.0085 |
25897 | RNF19A | CA_HPV_1 | Human | Cervix | CC | 2.00e-02 | 2.41e-02 | 0.0264 |
25897 | RNF19A | CCI_2 | Human | Cervix | CC | 3.27e-05 | 1.65e+00 | 0.5249 |
25897 | RNF19A | CCI_3 | Human | Cervix | CC | 3.25e-03 | 6.43e-01 | 0.516 |
25897 | RNF19A | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.43e-10 | -4.45e-01 | 0.0155 |
25897 | RNF19A | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.96e-04 | -5.19e-01 | -0.1207 |
25897 | RNF19A | HTA11_83_2000001011 | Human | Colorectum | SER | 3.43e-03 | -3.93e-01 | -0.1526 |
25897 | RNF19A | HTA11_696_2000001011 | Human | Colorectum | AD | 7.30e-16 | -5.07e-01 | -0.1464 |
25897 | RNF19A | HTA11_866_2000001011 | Human | Colorectum | AD | 1.32e-03 | -3.02e-01 | -0.1001 |
25897 | RNF19A | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.02e-02 | -5.95e-01 | -0.2061 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004586214 | Breast | IDC | positive regulation of proteolysis | 66/1434 | 372/18723 | 9.76e-11 | 1.29e-08 | 66 |
GO:001049814 | Breast | IDC | proteasomal protein catabolic process | 75/1434 | 490/18723 | 5.59e-09 | 4.41e-07 | 75 |
GO:004217614 | Breast | IDC | regulation of protein catabolic process | 63/1434 | 391/18723 | 1.32e-08 | 9.61e-07 | 63 |
GO:190336214 | Breast | IDC | regulation of cellular protein catabolic process | 46/1434 | 255/18723 | 4.00e-08 | 2.68e-06 | 46 |
GO:190305014 | Breast | IDC | regulation of proteolysis involved in cellular protein catabolic process | 41/1434 | 221/18723 | 9.77e-08 | 5.84e-06 | 41 |
GO:006113614 | Breast | IDC | regulation of proteasomal protein catabolic process | 33/1434 | 187/18723 | 5.24e-06 | 1.75e-04 | 33 |
GO:190336414 | Breast | IDC | positive regulation of cellular protein catabolic process | 29/1434 | 155/18723 | 5.93e-06 | 1.90e-04 | 29 |
GO:200005814 | Breast | IDC | regulation of ubiquitin-dependent protein catabolic process | 30/1434 | 164/18723 | 6.62e-06 | 2.05e-04 | 30 |
GO:004316114 | Breast | IDC | proteasome-mediated ubiquitin-dependent protein catabolic process | 57/1434 | 412/18723 | 9.55e-06 | 2.68e-04 | 57 |
GO:004573214 | Breast | IDC | positive regulation of protein catabolic process | 37/1434 | 231/18723 | 1.46e-05 | 3.71e-04 | 37 |
GO:190305213 | Breast | IDC | positive regulation of proteolysis involved in cellular protein catabolic process | 25/1434 | 133/18723 | 2.34e-05 | 5.59e-04 | 25 |
GO:190180014 | Breast | IDC | positive regulation of proteasomal protein catabolic process | 22/1434 | 114/18723 | 4.68e-05 | 1.04e-03 | 22 |
GO:000989614 | Breast | IDC | positive regulation of catabolic process | 62/1434 | 492/18723 | 7.06e-05 | 1.42e-03 | 62 |
GO:003243414 | Breast | IDC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 24/1434 | 134/18723 | 7.59e-05 | 1.50e-03 | 24 |
GO:00324368 | Breast | IDC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 18/1434 | 90/18723 | 1.39e-04 | 2.48e-03 | 18 |
GO:20000609 | Breast | IDC | positive regulation of ubiquitin-dependent protein catabolic process | 20/1434 | 107/18723 | 1.61e-04 | 2.76e-03 | 20 |
GO:003133114 | Breast | IDC | positive regulation of cellular catabolic process | 54/1434 | 427/18723 | 1.85e-04 | 3.07e-03 | 54 |
GO:004586224 | Breast | DCIS | positive regulation of proteolysis | 65/1390 | 372/18723 | 7.13e-11 | 9.17e-09 | 65 |
GO:001049824 | Breast | DCIS | proteasomal protein catabolic process | 75/1390 | 490/18723 | 1.44e-09 | 1.40e-07 | 75 |
GO:004217624 | Breast | DCIS | regulation of protein catabolic process | 62/1390 | 391/18723 | 9.98e-09 | 7.53e-07 | 62 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF19A | SNV | Missense_Mutation | novel | c.1474N>G | p.Thr492Ala | p.T492A | Q9NV58 | protein_coding | tolerated(0.46) | possibly_damaging(0.446) | TCGA-CV-6937-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RNF19A | SNV | Missense_Mutation | novel | c.623N>T | p.Arg208Leu | p.R208L | Q9NV58 | protein_coding | deleterious(0.02) | possibly_damaging(0.84) | TCGA-CV-6941-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
RNF19A | SNV | Missense_Mutation | novel | c.643N>A | p.Asp215Asn | p.D215N | Q9NV58 | protein_coding | tolerated(0.08) | probably_damaging(0.998) | TCGA-CV-7091-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RNF19A | SNV | Missense_Mutation | novel | c.406C>G | p.Leu136Val | p.L136V | Q9NV58 | protein_coding | deleterious(0.02) | probably_damaging(0.938) | TCGA-KU-A66S-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
RNF19A | SNV | Missense_Mutation | novel | c.1297N>A | p.Val433Met | p.V433M | Q9NV58 | protein_coding | tolerated(0.08) | probably_damaging(0.997) | TCGA-QK-A8Z8-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | PD |
RNF19A | SNV | Missense_Mutation | rs563127836 | c.1928N>A | p.Arg643Gln | p.R643Q | Q9NV58 | protein_coding | tolerated_low_confidence(0.29) | benign(0.197) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
RNF19A | deletion | Frame_Shift_Del | c.187delA | p.Arg63GlufsTer5 | p.R63Efs*5 | Q9NV58 | protein_coding | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
RNF19A | deletion | Frame_Shift_Del | c.187delA | p.Arg63GlufsTer5 | p.R63Efs*5 | Q9NV58 | protein_coding | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | |||
RNF19A | deletion | Frame_Shift_Del | c.187delN | p.Arg63GlufsTer5 | p.R63Efs*5 | Q9NV58 | protein_coding | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD | |||
RNF19A | deletion | Frame_Shift_Del | c.187delA | p.Arg63GlufsTer5 | p.R63Efs*5 | Q9NV58 | protein_coding | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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