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Gene: PRLR |
Gene summary for PRLR |
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Gene information | Species | Human | Gene symbol | PRLR | Gene ID | 5618 |
Gene name | prolactin receptor | |
Gene Alias | HPRL | |
Cytomap | 5p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P16471 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5618 | PRLR | GSM4909293 | Human | Breast | IDC | 9.59e-11 | 3.20e-01 | 0.1581 |
5618 | PRLR | GSM4909298 | Human | Breast | IDC | 3.79e-14 | 4.59e-01 | 0.1551 |
5618 | PRLR | GSM4909302 | Human | Breast | IDC | 1.52e-13 | 5.00e-01 | 0.1545 |
5618 | PRLR | GSM4909303 | Human | Breast | IDC | 4.67e-08 | 5.72e-01 | 0.0438 |
5618 | PRLR | GSM4909306 | Human | Breast | IDC | 5.45e-07 | 3.52e-01 | 0.1564 |
5618 | PRLR | GSM4909311 | Human | Breast | IDC | 4.79e-09 | -1.18e-01 | 0.1534 |
5618 | PRLR | GSM4909317 | Human | Breast | IDC | 1.68e-12 | 3.93e-01 | 0.1355 |
5618 | PRLR | GSM4909319 | Human | Breast | IDC | 4.39e-12 | -1.32e-01 | 0.1563 |
5618 | PRLR | GSM4909321 | Human | Breast | IDC | 3.34e-04 | -1.21e-01 | 0.1559 |
5618 | PRLR | M1 | Human | Breast | IDC | 4.18e-05 | 3.20e-01 | 0.1577 |
5618 | PRLR | NCCBC2 | Human | Breast | DCIS | 2.96e-03 | 4.80e-01 | 0.1554 |
5618 | PRLR | P1 | Human | Breast | IDC | 2.02e-03 | 1.23e-01 | 0.1527 |
5618 | PRLR | P3 | Human | Breast | IDC | 2.26e-03 | 5.24e-01 | 0.1542 |
5618 | PRLR | DCIS2 | Human | Breast | DCIS | 1.06e-25 | -4.69e-02 | 0.0085 |
5618 | PRLR | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.82e-09 | -3.84e-01 | 0.0155 |
5618 | PRLR | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.54e-02 | -4.76e-01 | -0.1207 |
5618 | PRLR | HTA11_696_2000001011 | Human | Colorectum | AD | 3.79e-02 | -2.72e-01 | -0.1464 |
5618 | PRLR | HTA11_866_2000001011 | Human | Colorectum | AD | 7.05e-03 | -3.08e-01 | -0.1001 |
5618 | PRLR | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.37e-02 | -4.09e-01 | 0.0338 |
5618 | PRLR | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.98e-09 | -3.87e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000756511 | Breast | IDC | female pregnancy | 39/1434 | 193/18723 | 1.81e-08 | 1.27e-06 | 39 |
GO:00447061 | Breast | IDC | multi-multicellular organism process | 41/1434 | 220/18723 | 8.58e-08 | 5.19e-06 | 41 |
GO:004873214 | Breast | IDC | gland development | 64/1434 | 436/18723 | 3.47e-07 | 1.74e-05 | 64 |
GO:000756611 | Breast | IDC | embryo implantation | 14/1434 | 53/18723 | 3.14e-05 | 7.32e-04 | 14 |
GO:005087813 | Breast | IDC | regulation of body fluid levels | 50/1434 | 379/18723 | 1.12e-04 | 2.10e-03 | 50 |
GO:003087911 | Breast | IDC | mammary gland development | 23/1434 | 137/18723 | 2.87e-04 | 4.37e-03 | 23 |
GO:00066944 | Breast | IDC | steroid biosynthetic process | 25/1434 | 173/18723 | 1.56e-03 | 1.56e-02 | 25 |
GO:00075652 | Breast | DCIS | female pregnancy | 37/1390 | 193/18723 | 7.85e-08 | 4.47e-06 | 37 |
GO:00447062 | Breast | DCIS | multi-multicellular organism process | 39/1390 | 220/18723 | 3.05e-07 | 1.46e-05 | 39 |
GO:004873223 | Breast | DCIS | gland development | 60/1390 | 436/18723 | 2.50e-06 | 8.74e-05 | 60 |
GO:005087823 | Breast | DCIS | regulation of body fluid levels | 50/1390 | 379/18723 | 5.17e-05 | 1.06e-03 | 50 |
GO:00075662 | Breast | DCIS | embryo implantation | 13/1390 | 53/18723 | 1.00e-04 | 1.82e-03 | 13 |
GO:003087921 | Breast | DCIS | mammary gland development | 22/1390 | 137/18723 | 4.74e-04 | 6.24e-03 | 22 |
GO:000669411 | Breast | DCIS | steroid biosynthetic process | 23/1390 | 173/18723 | 4.63e-03 | 3.52e-02 | 23 |
GO:00075952 | Breast | DCIS | lactation | 9/1390 | 47/18723 | 6.96e-03 | 4.78e-02 | 9 |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0030879 | Colorectum | AD | mammary gland development | 53/3918 | 137/18723 | 1.46e-06 | 4.58e-05 | 53 |
GO:0009755 | Colorectum | AD | hormone-mediated signaling pathway | 64/3918 | 190/18723 | 2.78e-05 | 5.24e-04 | 64 |
GO:0033674 | Colorectum | AD | positive regulation of kinase activity | 131/3918 | 467/18723 | 1.28e-04 | 1.85e-03 | 131 |
GO:0050878 | Colorectum | AD | regulation of body fluid levels | 108/3918 | 379/18723 | 2.54e-04 | 3.20e-03 | 108 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04151 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa041511 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa041512 | Colorectum | CRC | PI3K-Akt signaling pathway | 64/1091 | 354/8465 | 2.70e-03 | 1.77e-02 | 1.20e-02 | 64 |
hsa041513 | Colorectum | CRC | PI3K-Akt signaling pathway | 64/1091 | 354/8465 | 2.70e-03 | 1.77e-02 | 1.20e-02 | 64 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa04917 | Liver | HCC | Prolactin signaling pathway | 43/4020 | 70/8465 | 1.30e-02 | 3.19e-02 | 1.78e-02 | 43 |
hsa049171 | Liver | HCC | Prolactin signaling pathway | 43/4020 | 70/8465 | 1.30e-02 | 3.19e-02 | 1.78e-02 | 43 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRLR | SNV | Missense_Mutation | novel | c.637G>A | p.Gly213Arg | p.G213R | P16471 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CN-6994-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRLR | SNV | Missense_Mutation | novel | c.1286C>A | p.Ser429Tyr | p.S429Y | P16471 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-CN-A63U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PRLR | SNV | Missense_Mutation | novel | c.1285T>C | p.Ser429Pro | p.S429P | P16471 | protein_coding | tolerated(0.22) | benign(0.029) | TCGA-CN-A63U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PRLR | SNV | Missense_Mutation | novel | c.94N>C | p.Glu32Gln | p.E32Q | P16471 | protein_coding | tolerated(0.44) | benign(0.019) | TCGA-CV-6936-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PRLR | SNV | Missense_Mutation | novel | c.652N>G | p.Trp218Gly | p.W218G | P16471 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CV-7424-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PRLR | SNV | Missense_Mutation | rs139147779 | c.1459N>A | p.Asp487Asn | p.D487N | P16471 | protein_coding | tolerated(0.28) | benign(0.007) | TCGA-CV-A45P-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PRLR | SNV | Missense_Mutation | novel | c.376C>G | p.Gln126Glu | p.Q126E | P16471 | protein_coding | tolerated(1) | benign(0) | TCGA-QK-A8Z7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
PRLR | SNV | Missense_Mutation | c.701A>G | p.Asp234Gly | p.D234G | P16471 | protein_coding | deleterious(0) | possibly_damaging(0.706) | TCGA-B7-5818-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PRLR | SNV | Missense_Mutation | c.185N>C | p.Leu62Pro | p.L62P | P16471 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PRLR | SNV | Missense_Mutation | c.112N>C | p.Ser38Pro | p.S38P | P16471 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-D7-A4YT-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5618 | PRLR | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME, KINASE | LFA-102 | |||
5618 | PRLR | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME, KINASE | SOMATROPIN | SOMATROPIN | ||
5618 | PRLR | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME, KINASE | DHT | ANDROSTANOLONE | 1544711 | |
5618 | PRLR | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME, KINASE | SOMATROPIN RECOMBINANT | |||
5618 | PRLR | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME, KINASE | agonist | 178101594 | ||
5618 | PRLR | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME, KINASE | Prolanta | |||
5618 | PRLR | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME, KINASE | Endostatin | ENDOSTATIN | ||
5618 | PRLR | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME, KINASE | agonist | 178101593 |
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