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Gene: PCNX3 |
Gene summary for PCNX3 |
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Gene information | Species | Human | Gene symbol | PCNX3 | Gene ID | 399909 |
Gene name | pecanex 3 | |
Gene Alias | PCNXL3 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H6A9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
399909 | PCNX3 | HCC1 | Human | Liver | HCC | 3.31e-02 | 2.09e+00 | 0.5336 |
399909 | PCNX3 | HCC2 | Human | Liver | HCC | 4.23e-05 | 2.38e+00 | 0.5341 |
399909 | PCNX3 | S014 | Human | Liver | HCC | 1.86e-09 | 3.11e-01 | 0.2254 |
399909 | PCNX3 | S015 | Human | Liver | HCC | 3.13e-06 | 3.32e-01 | 0.2375 |
399909 | PCNX3 | S016 | Human | Liver | HCC | 2.64e-10 | 2.88e-01 | 0.2243 |
399909 | PCNX3 | S027 | Human | Liver | HCC | 1.02e-04 | 3.53e-01 | 0.2446 |
399909 | PCNX3 | S028 | Human | Liver | HCC | 1.98e-25 | 6.35e-01 | 0.2503 |
399909 | PCNX3 | S029 | Human | Liver | HCC | 2.31e-16 | 5.42e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCNX3 | SNV | Missense_Mutation | novel | c.4342N>T | p.Arg1448Cys | p.R1448C | Q9H6A9 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PCNX3 | SNV | Missense_Mutation | rs538665832 | c.1196N>A | p.Arg399Gln | p.R399Q | Q9H6A9 | protein_coding | tolerated(0.07) | benign(0) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCNX3 | SNV | Missense_Mutation | novel | c.4343N>A | p.Arg1448His | p.R1448H | Q9H6A9 | protein_coding | deleterious(0.01) | benign(0.025) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCNX3 | SNV | Missense_Mutation | novel | c.5099C>T | p.Ala1700Val | p.A1700V | Q9H6A9 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-E6-A2P8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PCNX3 | SNV | Missense_Mutation | novel | c.3569N>A | p.Arg1190His | p.R1190H | Q9H6A9 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCNX3 | SNV | Missense_Mutation | novel | c.3971N>A | p.Arg1324His | p.R1324H | Q9H6A9 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCNX3 | SNV | Missense_Mutation | rs775804738 | c.3970C>T | p.Arg1324Cys | p.R1324C | Q9H6A9 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCNX3 | SNV | Missense_Mutation | rs754177276 | c.4129G>A | p.Ala1377Thr | p.A1377T | Q9H6A9 | protein_coding | deleterious(0.03) | probably_damaging(0.984) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCNX3 | SNV | Missense_Mutation | novel | c.5566G>A | p.Ala1856Thr | p.A1856T | Q9H6A9 | protein_coding | tolerated(0.2) | benign(0) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCNX3 | SNV | Missense_Mutation | novel | c.3958N>A | p.His1320Asn | p.H1320N | Q9H6A9 | protein_coding | tolerated(0.49) | probably_damaging(0.954) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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